Yves Pommier

TL;DR: A previously established database that allows the identification of lead compounds in the early stages of drug discovery that are not ATP-binding cassette (ABC) transporter substrates is used and two platforms are found to be superior methods for the analysis of expression profiles of highly homologous gene superfamilies.

TL;DR: Experiments using nucleoid sedimentation to assess the DNA linking number and domain size from cells treated with Me2SO and thiourea indicated that these chemicals alter chromatin structure in a fashion which may account for effects on intercalator-induced DNA scission.

TL;DR: Investigation of how similar functionalities could be "translated" to the indenoisoquinoline system and how stereochemistry and hydrogen bonding affect biological activity found a stereochemical dependence was also observed for carbohydrate-derived indenoiseoquinolines.

TL;DR: The results reported here suggest using SULT1A1 and gamma-H2AX as biomarkers for prediction of AF activity during patient selection and monitoring of clinical trials and suggest that both N-sulfoxy-groups can be further converted to nitrenium ions that form adducts with DNA and proteins.

TL;DR: In this paper , mass spectrometry-based interactomes of trapped and non-trapped poly(ADP-ribose) polymerase (PARP) inhibitors are delineated.