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Yves Pommier
Researcher at National Institutes of Health
Publications - 847
Citations - 65543
Yves Pommier is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Topoisomerase & DNA. The author has an hindex of 123, co-authored 789 publications receiving 58898 citations. Previous affiliations of Yves Pommier include Purdue University & Kyushu University.
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Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication
Dongyi Xu,Parameswary A. Muniandy,Elisabetta Leo,Jinhu Yin,Saravanabhavan Thangavel,Xi Shen,Miki,Keli Agama,Rong Guo,David A. Fox,Amom Ruhikanta Meetei,Lauren E. Wilson,Huy Nguyen,Nan Ping Weng,Steven J. Brill,Lei Li,Alessandro Vindigni,Yves Pommier,Michael M. Seidman,Weidong Wang +19 more
TL;DR: V vertebrate Rif1 contains a DNA‐binding domain that resembles the αCTD domain of bacterial RNA polymerase α; and this domain preferentially binds fork and Holliday junction (HJ) DNA in vitro and is required for R if1 to resist replication stress in vivo.
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Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1–CBFβ interaction
Lea Cunningham,Steven M. Finckbeiner,R. Katherine Hyde,Noel Southall,Juan J. Marugan,Venkat R. K. Yedavalli,Seameen Dehdashti,William C. Reinhold,Lemlem Alemu,Ling Zhao,Jing-Ruey J. Yeh,Raman Sood,Yves Pommier,Christopher P. Austin,Kuan-Teh Jeang,Wei Zheng,Paul P. Liu +16 more
TL;DR: It is confirmed that RUNX1–CBFβ interaction can be targeted for leukemia treatment and a promising lead compound is identified for this purpose.
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Tetrandrine induces early G1 arrest in human colon carcinoma cells by down-regulating the activity and inducing the degradation of G1-S-specific cyclin-dependent kinases and by inducing p53 and p21Cip1.
TL;DR: It is found that micromolar concentrations of tetrandrine irreversibly inhibit the proliferation of human colon carcinoma cells in MTT and clonogenic assays by arresting cells in G1 by convergent mechanisms.
Journal Article
Gemcitabine (2′,2′-Difluoro-2′-Deoxycytidine), an Antimetabolite That Poisons Topoisomerase I
Philippe Pourquier,Christopher Gioffre,Glenda Kohlhagen,Yoshimasa Urasaki,François Goldwasser,Lary W. Hertel,Shuyuan Yu,Richard T. Pon,William H. Gmeiner,Yves Pommier +9 more
TL;DR: The enhancement of camptothecin-induced top1 cleavage complexes may, at least in part, contribute to the synergistic or additive effects of gemcitabine in combination with topotecan and irinotecans in human breast or lung cancer cells.
Journal Article
Topoisomerase I-mediated Cytotoxicity of N-Methyl-N′-nitro-N-nitrosoguanidine: Trapping of Topoisomerase I by the O6-Methylguanine
Philippe Pourquier,Jessica L. Waltman,Yoshimasa Urasaki,Natalia A. Loktionova,Anthony E. Pegg,John L. Nitiss,Yves Pommier +6 more
TL;DR: A role for Top1 poisoning by alkylated bases in the antiproliferative activity of alkylating agents as well as in the DNA lesions resulting from endogenous and carcinogenic DNA modifications is suggested.