Chittagong Medical College Hospital

About: Chittagong Medical College Hospital is a healthcare organization based out in Chittagong, Bangladesh. It is known for research contribution in the topics: Population & Malaria. The organization has 676 authors who have published 601 publications receiving 7040 citations.

Late presentation of epigastric heteropagus

Abstract: Parasitic twins can attach to the host at a number of different locations. The most usual variant is caudal duplication (dipygus), where the parasite consists of additional pelvic and lower limb structures attached to the pelvis of the dominant twin. Less commonly, the rudimentary twin can attach to the anterior thorax, the thoracic spine, or the epigastrium, as in this case. A 13-year-old boy was successfully managed and represents the eighth case of epigastric heteropagus reported, and the oldest presentation of such a case.

Quantitation of paracetamol by liquid chromatography-mass spectrometry in human plasma in support of clinical trial.

Abstract: Aim: Paracetamol is a well-tolerated antipyretic widely used in severe malaria management. The study aimed to develop and validate a rapid LC–MS/MS assay to quantify paracetamol in plasma from patients with severe malaria. Materials & methods: Plasma sample was precipitated by organic solvent containing isotope-labeled paracetamol internal standard. Supernatant was isolated, diluted with water, followed by LC–MS/MS analysis. Results: Plasma samples were extracted and assayed in less than 5.5 min. The assay response was linear (0.125–50 mg/l) with total intra- and interassay imprecision of <1.4%, which were considerably lower than most published reports. Conclusion: We developed, validated and applied a rapid and small volume LC–MS/MS assay with high precision and accuracy for plasma paracetamol quantitation in 989 samples from 62 patients with severe malaria. The simple and high-throughput quality could facilitate assay automation for future clinical studies.

Reproducible diagnostic metabolites in plasma from typhoid fever patients in Asia and Africa

Abstract: Salmonella Typhi is the causative agent of typhoid. Typhoid is diagnosed by blood culture, a method that lacks sensitivity, portability and speed. We have previously shown that specific metabolomic profiles can be detected in the blood of typhoid patients from Nepal (Nasstrom et al., 2014). Here, we performed mass spectrometry on plasma from Bangladeshi and Senegalese patients with culture confirmed typhoid fever, clinically suspected typhoid, and other febrile diseases including malaria. After applying supervised pattern recognition modelling, we could significantly distinguish metabolite profiles in plasma from the culture confirmed typhoid patients. After comparing the direction of change and degree of multivariate significance, we identified 24 metabolites that were consistently up- or down regulated in a further Bangladeshi/Senegalese validation cohort, and the Nepali cohort from our previous work. We have identified and validated a metabolite panel that can distinguish typhoid from other febrile diseases, providing a new approach for typhoid diagnostics.

Computed Tomography Guided Fine Needle Aspiration Cytology of Lung Lesions: A Study of 162 Cases

Abstract: Key words: CT; FNAC; Lung DOI: 10.3329/jcmcta.v20i1.4936 Journal of Chittagong Medical College Teachers' Association 2009: 20(1):50-52

Left sided acute appendicitis with situs inversus in an elderly - an unusual case

Abstract: doi: 10.3329/jcmcta.v18i1.3818 Journal of Chittagong Medical College Teachers' Association 2007: 18(1):29-31