Institution
Hanyang University
Education•Seoul, South Korea•
About: Hanyang University is a education organization based out in Seoul, South Korea. It is known for research contribution in the topics: Thin film & Population. The organization has 29387 authors who have published 58815 publications receiving 1190144 citations. The organization is also known as: Hanyang Taehakkyo.
Topics: Thin film, Population, Oxide, Membrane, Catalysis
Papers published on a yearly basis
Papers
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University of Queensland1, Nuffield Orthopaedic Centre2, Hanyang University3, Cedars-Sinai Medical Center4, National Institutes of Health5, University of Paris6, University of Oslo7, Danube University Krems8, King Abdulaziz University9, National Institute for Health and Welfare10, Second Military Medical University11, Ghent University12, National Autonomous University of Mexico13, University of Otago14, University of Toronto15, Royal Brisbane and Women's Hospital16, Autonomous University of Madrid17, Central University, India18, Wellcome Trust Sanger Institute19, University of Oxford20, Norfolk and Norwich University Hospital21, University of Cambridge22, University Health Network23, Memorial University of Newfoundland24, University of Alberta25, Nova Southeastern University26, Norwegian University of Science and Technology27, Universidad de La Sabana28, Spanish National Research Council29, Université Paris-Saclay30, Medical Research Council31
TL;DR: In this paper, the authors used the Illumina Immunochip microarray to perform a case-control association study involving 10,619 individuals with ankylosing spondylitis (cases) and 15,145 controls.
Abstract: Ankylosing spondylitis is a common, highly heritable inflammatory arthritis affecting primarily the spine and pelvis. In addition to HLA-B*27 alleles, 12 loci have previously been identified that are associated with ankylosing spondylitis in populations of European ancestry, and 2 associated loci have been identified in Asians. In this study, we used the Illumina Immunochip microarray to perform a case-control association study involving 10,619 individuals with ankylosing spondylitis (cases) and 15,145 controls. We identified 13 new risk loci and 12 additional ankylosing spondylitis-associated haplotypes at 11 loci. Two ankylosing spondylitis-associated regions have now been identified encoding four aminopeptidases that are involved in peptide processing before major histocompatibility complex (MHC) class I presentation. Protective variants at two of these loci are associated both with reduced aminopeptidase function and with MHC class I cell surface expression.
620 citations
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TL;DR: Anifrolumab, a human monoclonal antibody to type I interferon receptor subunit 1 investigated for the treatment of systemic lupus erythematosus (SLE), did not have a significant effect as discussed by the authors.
Abstract: Background Anifrolumab, a human monoclonal antibody to type I interferon receptor subunit 1 investigated for the treatment of systemic lupus erythematosus (SLE), did not have a significant...
620 citations
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TL;DR: In this paper, a tradeoff relation and upper bound between water permeability and water/salt selectivity are observed. But, the authors do not consider the effect of sample size and measurement variables (e.g., pressure and salt concentration in the case of salt rejection).
617 citations
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TL;DR: The roles of inflammatory response in neurodegenerative diseases are discussed, focusing on the contributions of microglia and astrocytes and their relationship, and biomarkers to measure neuro inflammation and studies on therapeutic drugs that can modulate neuroinflammation are discussed.
Abstract: Neuroinflammation is associated with neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Microglia and astrocytes are key regulators of inflammatory responses in the central nervous system. The activation of microglia and astrocytes is heterogeneous and traditionally categorized as neurotoxic (M1-phenotype microglia and A1-phenotype astrocytes) or neuroprotective (M2-phenotype microglia and A2-phenotype astrocytes). However, this dichotomized classification may not reflect the various phenotypes of microglia and astrocytes. The relationship between these activated glial cells is also very complicated, and the phenotypic distribution can change, based on the progression of neurodegenerative diseases. A better understanding of the roles of microglia and astrocytes in neurodegenerative diseases is essential for developing effective therapies. In this review, we discuss the roles of inflammatory response in neurodegenerative diseases, focusing on the contributions of microglia and astrocytes and their relationship. In addition, we discuss biomarkers to measure neuroinflammation and studies on therapeutic drugs that can modulate neuroinflammation.
616 citations
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TL;DR: These findings suggest that synapse number and function are decreased in the dlPFC of patients with major depressive disorder, and identify a transcriptional repressor, GATA1, expression of which is higher in MDD and is sufficient to decrease the expression of synapse-related genes, cause loss of dendritic spines and dendrites, and produce depressive behavior in rat models of depression.
Abstract: Previous imaging and postmortem studies have reported a lower brain volume and a smaller size and density of neurons in the dorsolateral prefrontal cortex (dlPFC) of subjects with major depressive disorder (MDD). These findings suggest that synapse number and function are decreased in the dlPFC of patients with MDD. However, there has been no direct evidence reported for synapse loss in MDD, and the gene expression alterations underlying these effects have not been identified. Here we use microarray gene profiling and electron microscopic stereology to reveal lower expression of synaptic-function–related genes (CALM2, SYN1, RAB3A, RAB4B and TUBB4) in the dlPFC of subjects with MDD and a corresponding lower number of synapses. We also identify a transcriptional repressor, GATA1, expression of which is higher in MDD and that, when expressed in PFC neurons, is sufficient to decrease the expression of synapse-related genes, cause loss of dendritic spines and dendrites, and produce depressive behavior in rat models of depression.
609 citations
Authors
Showing all 29583 results
Name | H-index | Papers | Citations |
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John A. Rogers | 177 | 1341 | 127390 |
Charles M. Lieber | 165 | 521 | 132811 |
Jongmin Lee | 150 | 2257 | 134772 |
Rajesh Kumar | 149 | 4439 | 140830 |
Prashant V. Kamat | 140 | 725 | 79259 |
Tae Jeong Kim | 132 | 1420 | 93959 |
Jie Liu | 131 | 1531 | 68891 |
Junghwan Goh | 128 | 1068 | 77137 |
Young Hee Lee | 122 | 1168 | 61107 |
Allan H. MacDonald | 119 | 926 | 56221 |
Terence G. Langdon | 117 | 1158 | 61603 |
Yang-Kook Sun | 117 | 781 | 58912 |
Sang Yup Lee | 117 | 1005 | 53257 |
Yoshinobu Unno | 115 | 875 | 66107 |
Xi Chen | 105 | 1547 | 52533 |