Institution
Shandong Normal University
Education•Jinan, Shandong, China•
About: Shandong Normal University is a education organization based out in Jinan, Shandong, China. It is known for research contribution in the topics: Laser & Catalysis. The organization has 12378 authors who have published 12576 publications receiving 174572 citations.
Topics: Laser, Catalysis, Computer science, Nonlinear system, Cluster analysis
Papers published on a yearly basis
Papers
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TL;DR: It is found that DHA shows a dose-dependent inhibition of proliferation and migration of in HUVECs and down-regulates the mRNA and protein expression of VEGfr2 in endothelial cells, suggesting defective NF-κB signaling may underlie the observed effects of DHA on VEGFR2 expression.
Abstract: The anti-malarial agent dihydroartemisinin (DHA) has strong anti-angiogenic activity. This study aimed to investigate the molecular mechanism underlying this effect of DHA on angiogenesis. We found that DHA shows a dose-dependent inhibition of proliferation and migration of in HUVECs. DHA specifically down-regulates the mRNA and protein expression of VEGFR2 in endothelial cells. Treatment with DHA increases IκB-α protein and blocks nuclear translocation of NF-κB p65. In addition, DHA directly regulates VEGFR2 promoter activity through p65 binding motif, and decreases the binding activity of p65 and VEGFR2 promoter, suggesting defective NF-κB signaling may underlie the observed effects of DHA on VEGFR2 expression. In the presence of the NF-κB inhibitor PDTC, DHA could not further repress VEGFR2. Co-treatment with PDTC and DHA produced minimal changes compared to the effects of either drug alone in in vitro angiogenesis assays. Similar findings were found in vivo through a mouse retinal neovascularization model examining the effects of PDTC and DHA. Our data suggested that DHA inhibits angiogenesis largely through repression of the NF-κB pathway. DHA is well tolerated, and therefore may be an ideal candidate to use clinically as an angiogenesis inhibitor for cancer treatment.
68 citations
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TL;DR: Single-molecule detection of PNK is demonstrated for the first time based on phosphorylation-directed recovery of fluorescence quenched by Au nanoparticle (AuNP) in combination with lambda exonuclease-mediated cleavage reaction.
Abstract: 5′-Polynucleotide kinase such as T4 polynucleotide kinase (T4 PNK) may catalyze the phosphorylation of 5′-hydroxyl termini in nucleic acids, playing a crucial role in DNA replication, DNA recombination, and DNA damage repair. Here, we demonstrate for the first time single-molecule detection of PNK based on phosphorylation-directed recovery of fluorescence quenched by Au nanoparticle (AuNP) in combination with lambda exonuclease-mediated cleavage reaction. In the presence of PNK, the γ-phosphate group from adenosine triphosphate (ATP) is transferred to 5′-hydroxyl terminus, resulting in 5′-phosphorylation of the hairpin probe. The phosphorylated hairpin probes may function as the substrates of lambda exonuclease and enable the removal of 5′ mononucleotides from the stem, leading to the unfolding of hairpin structure and the formation of binding probes. The resultant binding probes may specifically hybridize with the AuNP-modified capture probes, forming double-strand DNA (dsDNA) duplexes with 5′-phosphate ...
68 citations
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TL;DR: The first polynitrile coordinated lanthanide complex has been synthesized and the two-dimensional structure coordination polymer exhibits strong fluorescence emission and strong powder second harmonic generation efficiency (16.8 times that of urea).
68 citations
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TL;DR: The existence of one solution for a boundary value problem of fractional order is considered in this paper, in which the Schauder fixed point theorem is used to prove the existence of a solution.
Abstract: The existence of one solution for a boundary value problem of fractional order is considered,involving α∈(3,4],Dα0+u(t)+f(t,u(t),u′(t))=0u(0)=0,u′(0)=0u″(1)=0,u'''(1)=g(u(1)) by using the Schauder fixed point theorem
68 citations
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TL;DR: The recent advances in single QD-based nanosensors and their applications for sensitive detection of DNAs, microRNAs, proteins, enzymes, small molecules and viruses are summarized.
68 citations
Authors
Showing all 12482 results
Name | H-index | Papers | Citations |
---|---|---|---|
Feng Zhang | 172 | 1278 | 181865 |
Jinde Cao | 117 | 1430 | 57881 |
Wei Zhang | 112 | 1189 | 93641 |
Miao Liu | 111 | 993 | 59811 |
Qian Wang | 108 | 2148 | 65557 |
Jun Yang | 107 | 2090 | 55257 |
Feng Li | 104 | 995 | 60692 |
Feng Chen | 95 | 2138 | 53881 |
Gang Li | 93 | 486 | 68181 |
Jianhong Wu | 93 | 726 | 36427 |
Chen-Ho Tung | 89 | 662 | 30111 |
Shu Tao | 87 | 639 | 27304 |
Bernhard Hommel | 85 | 475 | 28851 |
Lingxin Chen | 85 | 421 | 25147 |
Bo Tang | 83 | 706 | 24472 |