Shandong Normal University

About: Shandong Normal University is a education organization based out in Jinan, Shandong, China. It is known for research contribution in the topics: Laser & Catalysis. The organization has 12378 authors who have published 12576 publications receiving 174572 citations.

Nanoscale optical probes for cellular imaging

Abstract: Nanomaterials with unique optical properties have shown great promise as probes for cellular imaging Based on these properties, a wide range of plasmonic, fluorescent and Raman probes have been designed and prepared Nanomaterials of different sizes and shapes have also been functionalized with various types of biomolecules, such as antibodies, DNA or RNA, which are actively exploited to realize targeted imaging In this review, we will summarize recent advances in using functional nanomaterials for imaging, primarily cellular imaging These nanomaterials are categorized based on their conducting properties, ie conductors, semiconductors and insulators

Locality Preserving Joint Transfer for Domain Adaptation

Abstract: Domain adaptation aims to leverage knowledge from a well-labeled source domain to a poorly labeled target domain. A majority of existing works transfer the knowledge at either feature level or sample level. Recent studies reveal that both of the paradigms are essentially important, and optimizing one of them can reinforce the other. Inspired by this, we propose a novel approach to jointly exploit feature adaptation with distribution matching and sample adaptation with landmark selection. During the knowledge transfer, we also take the local consistency between the samples into consideration so that the manifold structures of samples can be preserved. At last, we deploy label propagation to predict the categories of new instances. Notably, our approach is suitable for both homogeneous- and heterogeneous-domain adaptations by learning domain-specific projections. Extensive experiments on five open benchmarks, which consist of both standard and large-scale datasets, verify that our approach can significantly outperform not only conventional approaches but also end-to-end deep models. The experiments also demonstrate that we can leverage handcrafted features to promote the accuracy on deep features by heterogeneous adaptation.

Highly Specific and Ultrasensitive Two-Photon Fluorescence Imaging of Native HOCl in Lysosomes and Tissues Based on Thiocarbamate Derivatives

Abstract: Hypochlorous acid (HOCl) acts as a weak acid distributed mainly in acidic organelle lysosomes of phagocytes and plays a crucial role in the immune defense. The elaborate interrelation between the variations of HOCl levels in lysosomes and different physiological and pathological processes remains unclear. Thus, the accurate determination of lysosomal HOCl in living cells and in vivo is very important. Because of extremely low concentration and difficulty in distinguishing HOCl from OCl– under the physiological environment, it is still a great challenge to specifically monitor the intracellular intrinsic HOCl levels without exogenous stimulation, which impedes an exact understanding of its biological roles. In this paper, based on the electrophilic addition of Cl+ to sulfide moiety, we have developed a two-photon fluorescent probe O-(N-butyl-1,8-naphthalimide)-4-yl-N,N-dimethylthiocarbamate (NDMTC) for the specific determination of HOCl over OCl– and other bioactive molecules. Our results show that NDMTC p...