Shandong Normal University

About: Shandong Normal University is a education organization based out in Jinan, Shandong, China. It is known for research contribution in the topics: Laser & Catalysis. The organization has 12378 authors who have published 12576 publications receiving 174572 citations.

A New Polymer Nanoprobe Based on Chemiluminescence Resonance Energy Transfer for Ultrasensitive Imaging of Intrinsic Superoxide Anion in Mice

Abstract: Despite significant developments in optical imaging of superoxide anion (O2•–) as the preliminary reactive oxygen species, novel visualizing strategies that offer ultrahigh sensitivity are still imperative. This is mainly because intrinsic concentrations of O2•– are extremely low in living systems. Herein, we present the rational design and construction of a new polymer nanoprobe PCLA-O2•– for detecting O2•– based on chemiluminescence (CL) resonance energy transfer without an external excitation source. Structurally, PCLA-O2•– contains two moieties linked covalently, namely imidazopyrazinone that is capable of CL triggered by O2•– as the energy donor and conjugated polymers with light-amplifying property as the energy acceptor. Experiment results demonstrate that PCLA-O2•– exhibits ultrahigh sensitivity at the picomole level, dramatically prolonged luminescence time, specificity, and excellent biocompatibility. Without exogenous stimulation, this probe for the first time in situ visualizes O2•– level diff...

Highly efficient photocatalytic degradation of methylene blue by P2ABSA-modified TiO2 nanocomposite due to the photosensitization synergetic effect of TiO2 and P2ABSA

Abstract: To enhance the photocatalytic activity of TiO2, poly-2-aminobenzene sulfonic acid (P2ABSA)-modified TiO2 nanocomposites were successfully synthesized using an in situ oxidative polymerization method. The modified nanocomposites were characterized by scanning electron microscopy, X-ray diffraction, transmission electron microscopy, X-ray photoelectron spectroscopy, UV-vis diffuse reflectance spectroscopy, and a photocurrent test. The photocatalytic degradation of methylene blue was chosen as a model reaction to evaluate the photocatalytic activities of TiO2 and P2ABSA/TiO2 nanocomposites, with results indicating that P2ABSA/TiO2 exhibited the higher activity. The apparent first-order rate constant, kapp, of P/T(2/1) was 0.0138 min−1, which was six times higher than that of TiO2 (0.0021 min−1). Meanwhile, the P2ABSA/TiO2 nanocomposites showed excellent photocatalytic stability, which was dependent on structural stability. A photocatalytic activity enhanced mechanism has been proposed, accounting for the photosensitization effect and synergetic effect of TiO2 with P2ABSA. Mass spectroscopy analysis showed that there were two possible degradation pathways for MB, via degradation of the chromophoric group or the auxochrome group.

Boron Phosphide Nanoparticles: A Nonmetal Catalyst for High-Selectivity Electrochemical Reduction of CO 2 to CH 3 OH

Abstract: Electrocatalysis has emerged as an attractive way for artificial CO2 fixation to CH3 OH, but the design and development of metal-free electrocatalyst for highly selective CH3 OH formation still remains a key challenge. Here, it is demonstrated that boron phosphide nanoparticles perform highly efficiently as a nonmetal electrocatalyst toward electrochemical reduction of CO2 to CH3 OH with high selectivity. In 0.1 m KHCO3 , this catalyst achieves a high Faradaic efficiency of 92.0% for CH3 OH at -0.5 V versus reversible hydrogen electrode. Density functional theory calculations reveal that B and P synergistically promote the binding and activation of CO2 , and the rate-determining step for the CO2 reduction reaction is dominated by *CO + *OH to *CO + *H2 O process with free energy change of 1.36 eV. In addition, CO and CH2 O products are difficultly generated on BP (111) surface, which is responsible for the high activity and selectivity of the CO2 -to-CH3 OH conversion process.

A nuclear targeted dual-photosensitizer for drug-resistant cancer therapy with NIR activated multiple ROS

Abstract: Photodynamic therapy against cancer, especially multidrug resistant cancer, is limited seriously due to the efflux of photosensitizer molecules by P-glycoprotein, which leads to insufficient production of reactive oxygen species (ROS). For the purpose of abundant ROS generation and effective therapeutic response, herein, we firstly design and fabricate a nuclear targeted dual-photosensitizer for photodynamic therapy against multidrug resistant cancer. Molecule-photosensitizer Ce6 was selected and modified on the surface of core/shell structure nano-photosensitizer upconversion@TiO2 and then nuclear targeted peptides TAT were anchored for nuclear targeting. Through selective doping of rare earth elements Er and Tm, multiple ROS (˙OH, O2˙−, and 1O2) can be generated for the dual-photosensitizer and realize their functions synergistically using a single 980 nm NIR excitation. The nano-sized photosensitizer accompanied with nuclear targeting can effectively generate multiple ROS in the nucleus regardless of P-glycoprotein and directly break DNA double strands, which is considered as the most direct and serious lesion type for cytotoxic effects. Therefore, enhanced photodynamic therapy can be achieved against multidrug resistant cancer. In vitro and in vivo studies confirmed the excellent therapeutic effect of the dual-photosensitizer against cancer cells and drug-resistant cancer cells, as well as xenograft tumor models.