Shiv Nadar University

About: Shiv Nadar University is a education organization based out in Dadri, Uttar Pradesh, India. It is known for research contribution in the topics: Population & Graphene. The organization has 1015 authors who have published 1924 publications receiving 18420 citations.

Stereoselective synthesis of natural product inspired carbohydrate fused pyrano[3,2-c]quinolones as antiproliferative agents.

Abstract: Pyrano[3,2-c]quinolone structural motifs are commonly found in natural products with diverse biological activities As part of a research programme aimed at developing the efficient synthesis of natural product-like small molecules, we designed and developed the microwave assisted, facile stereoselective synthesis of two series of carbohydrate fused pyrano[3,2-c]quinolone derivatives (n = 23) starting from 2-C-formyl galactal and 2-C-formyl glucal, reacting with various 4-hydroxyquinolones in shorter reaction times (15-20 min) The antiproliferative activity of these synthesized pyrano[3,2-c]quinolones was determined against MCF-7 (breast) and HepG2 (liver) cancer cells The selected library members displayed low micromolar (353-968 μM) and selective antiproliferative activity These findings on carbohydrate fused pyrano[3,2-c]quinolone derivatives are expected to provide new leads for anticancer drug discovery

Study of Higher Discharge Capacity, Phase Transition, and Relative Structural Stability in Li2FeSiO4 Cathode upon Lithium Extraction Using an Experimental and Theoretical Approach and Full Cell Prototype Study

Abstract: We have revisited the study of the nanostructured lithium iron silicate-based cathode for a safe lithium-ion battery and to understand the reaction mechanism from the first cycle to the second cycl...

In-depth microscopic characterisation of the weld faying interface revealing stress-induced metallurgical transformations during friction stir spot welding

Abstract: Friction stir spot welding (FSSW) is a solid-state welding process, wherein the properties of a weld joint are influenced by the state of friction and localised thermodynamic conditions at the tool-workpiece interface. An issue well-known about FSSW joints is their lack of reliability since they abruptly delaminate at the weld-faying interface (WFI). This study explores the origins of the delamination of multiple lap welded aluminium alloy (AA 5754-H111) sheets joined by FSSW at different rotational speeds typically used in industry. Experimental techniques such as the small punch test (SPT), Vickers hardness test, Scanning Electron Microscopy (SEM), Scanning Acoustic Microscope (SAM), Transmission Electron Microscopy (TEM), Energy-dispersive X-ray spectroscopy (EDX) and Frequency-Modulated Kelvin Probe Force Microscopy (FM-KPFM) were employed. The experimental results revealed that a complex interplay of stress-assisted metallurgical transformations at the intersection of WFI and the recrystallised stir zone (RSZ) can trigger dynamic precipitation leading to the formation of Al3Mg2 intermetallic phase, while metallic oxides and nanopits remain entrapped in the WFI. These metallurgical transformations surrounded by pits, precipitates and oxides induces process instability which in turn paves way for fast fracture to become responsible for delamination.