University of British Columbia

About: University of British Columbia is a education organization based out in Vancouver, British Columbia, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 89939 authors who have published 209679 publications receiving 9226862 citations. The organization is also known as: UBC & The University of British Columbia.

Named Entity Recognition with Bidirectional LSTM-CNNs

Abstract: Named entity recognition is a challenging task that has traditionally required large amounts of knowledge in the form of feature engineering and lexicons to achieve high performance. In this paper, we present a novel neural network architecture that automatically detects word- and character-level features using a hybrid bidirectional LSTM and CNN architecture, eliminating the need for most feature engineering. We also propose a novel method of encoding partial lexicon matches in neural networks and compare it to existing approaches. Extensive evaluation shows that, given only tokenized text and publicly available word embeddings, our system is competitive on the CoNLL-2003 dataset and surpasses the previously reported state of the art performance on the OntoNotes 5.0 dataset by 2.13 F1 points. By using two lexicons constructed from publicly-available sources, we establish new state of the art performance with an F1 score of 91.62 on CoNLL-2003 and 86.28 on OntoNotes, surpassing systems that employ heavy feature engineering, proprietary lexicons, and rich entity linking information.

Language, Identity, and the Ownership of English

Abstract: This article serves as the introduction to the special-topic issue of the TESOL Quarterly on Language and Identity. In the first section, I discuss my interest in language and identity, drawing on theorists who have been influential in my work. A short vignette illustrates the significant relationship among identity, language learning, and classroom teaching. In the second section, I examine the five articles in the issue, highlighting notable similarities and differences in conceptions of identity. I note, in particular, the different ways in which the authors frame identity: social identity, sociocultural identity, voice, cultural identity, and ethnic identity. I explore these differences with reference to the particular disciplines and research traditions of the authors and the different emphases of their research projects. In the final section, I draw on the issue as a whole to address a prevalent theme in many of the contributions: the ownership of English internationally. The central question addressed is the extent to which English belongs to White native speakers of standard English or to all the people who speak it, irrespective of linguistic and sociocultural history. I conclude with the hope that the issue will help address the current fragmentation in the literature on the relationship between language and identity and encourage further debate and research on a thought-provoking and important topic. Just as, at the level of relations between groups, a language is worth what those who speak it are worth, so too, at the level of interactions between individuals, speech always owes a major part of its value to the value of the person who utters it. (Bourdieu, 1977, p. 652)

Metal nanoparticles: understanding the mechanisms behind antibacterial activity.

Abstract: As the field of nanomedicine emerges, there is a lag in research surrounding the topic of nanoparticle (NP) toxicity, particularly concerned with mechanisms of action. The continuous emergence of bacterial resistance has challenged the research community to develop novel antibiotic agents. Metal NPs are among the most promising of these because show strong antibacterial activity. This review summarizes and discusses proposed mechanisms of antibacterial action of different metal NPs. These mechanisms of bacterial killing include the production of reactive oxygen species, cation release, biomolecule damages, ATP depletion, and membrane interaction. Finally, a comprehensive analysis of the effects of NPs on the regulation of genes and proteins (transcriptomic and proteomic) profiles is discussed.

Antiretroviral Therapy for HIV Infection in 1997: Updated Recommendations of the International AIDS Society—USA Panel

Abstract: Objective. —To provide current recommendations for antiretroviral therapy for human immunodeficiency virus (HIV) disease. Participants. —The original International AIDS Society—USA 13-member panel representing international expertise in antiretroviral research and care of patients with HIV infection. Evidence. —The following were considered: Newly available clinical and basic science study results, including phase 3 controlled trials; clinical, virological, and immunologic end-point data; interim analyses of studies presented at national and international research conferences; studies of HIV pathophysiology; and expert opinions of panel members. Recommendations were limited to the drugs available in mid 1997. Process. —The full panel met on a regular basis (July 1996, September 1996, November 1996, January 1997, and April 1997) since the publication of its initial recommendations in mid 1996 to review new research reports and interim results. The panel discussed whether and how new information changed its initial recommendations. The recommendations contained herein were determined by group consensus. Conclusions. —New data have provided a stronger rationale for earlier initiation of more aggressive therapy than previously recommended and reinforce the importance of careful selection of initial drug regimen for each patient for optimal long-term clinical benefit and adherence. The plasma viral load is a crucial element of clinical management for assessing prognosis and the effectiveness of therapy, and such testing must be done properly. Treatment failure is most readily indicated by a rising plasma HIV RNA level and should be confirmed prior to a change of treatment. Therapeutic approaches must be updated as new data, particularly on the long-term clinical effect of aggressive antiretroviral treatment, continue to emerge.