Showing papers by "University of Pennsylvania published in 1985"

Anxiety Disorders and Phobias: A Cognitive Perspective

Abstract: Theoretical and Clinical Aspects by Aaron T. Beck * Turning Anxiety on Its Head: An Overview * Symptoms and Their Significance * The Cognitive Model of Threat Reactions * Cognitive Structures and Anxiogenic Rules * Vulnerability: The Core of Anxiety Disorders * Generalized Anxiety Disorder and Panic Disorder * Simple Phobias * The Agoraphobic Syndrome * The Evaluation Anxieties Cognitive Therapy: Techniques and Applications by Gary Emery * Principles of Cognitive Therapy * Strategies and Techniques for Cognitive Restructuring * Modifying Imagery * Modifying the Affective Component * Modifying the Behavioral Component * Restructuring a Patients Assumptions and Major Issues

Involvement of the bcl-2 gene in human follicular lymphoma

Abstract: Recombinant DNA probes were cloned for the areas flanking the breakpoint on chromosome 18 in cells from a patient with acute lymphocytic leukemia of the B-cell type; cells of this line carry the t(14;18) chromosomal translocation. Two of the probes detected DNA rearrangements in approximately 60 percent of the cases of follicular lymphoma screened. In follicular lymphoma, most of the breakpoints in band q21 of chromosome 18 were clustered within a short stretch of DNA, approximately 2.1 kilobases in length. Chromosome 18-specific DNA probes for the areas flanking the breakpoints also detected RNA transcripts 6 kilobases in length in various cell types. The gene coding for these transcript (the bcl-2 gene) seems to be interrupted in most cases of follicular lymphomas carrying the t(14;18) chromosomal translocation.

The c- myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

Abstract: Transgenic mice bearing the cellular myc oncogene coupled to the immunoglobulin mu or kappa enhancer frequently develop a fatal lymphoma within a few months of birth. Since the tumours represent represent both immature and mature B lymphocytes, constitutive c-myc expression appears to be highly leukaemogenic at several stages of B-cell maturation. These myc mice should aid study of lymphoma development, B-cell ontogeny and immunoglobulin regulation.

Microcomputer analyses of performance on a portable, simple visual RT task during sustained operations

Abstract: The Institute of Pennsylvania Hospital and University of Pennsylvania, Philadelphia, Pennsylvania There is a need for brief, portable performance measures that are free of practice effects but that reliably show the impact of sleep loss on performance during sustained work. Reaction time (RT) tasks hold considerable promise in meeting this need, if the extensive number of responses they typically yield can be processed in ways that quickly provide the essential analyses. While testing the utility of a portable visual RT task during a sustained, quasi-continuous work schedule of 54 h, we developed a microcomputer software system that inputs, edits, transforms, analyzes, and reduces the data from the RT portable audiotapes, for each 10-min trial on the task. With relatively minor modifications, the software system can be used on a minimally configured microcomputer system that supports BASIC. The software is flexible and capable of retrieving distorted data, and it generates a variety of dependent variables reflecting intratrial optimum response capacity, lapsing, and response slowing.

A new polynomial invariant of knots and links

Abstract: The purpose of this note is to announce a new isotopy invariant of oriented links of tamely embedded circles in 3-space. We represent links by plane projections, using the customary conventions that the image of the link is a union of transversely intersecting immersed curves, each provided with an orientation, and undercrossings are indicated by broken lines. Following Conway [6], we use the symbols L+, Lo, L_ to denote links having plane projections which agree except in a small disk, and inside that disk are represented by the pictures of Figure 1. Conway showed that the one-variable Alexander polynomials of L+, Lo, L_ (when suitably normalized) satisfy the relation

Production of transgenic rabbits, sheep and pigs by microinjection

Abstract: Direct microinjection has been used to introduce foreign DNA into a number of terminally differentiated cell types as well as embryos of several species including sea urchin, Candida elegans, Xenopus, Drosophila and mice. Various genes have been successfully introduced into mice including constructs consisting of the mouse metallothionein-I (MT) promoter/regulator region fused to either the rat or human growth hormone (hGH) structural genes. Transgenic mice harbouring such genes commonly exhibit high, metal-inducible levels of the fusion messenger RNA in several organs, substantial quantities of the foreign growth hormone in serum and enhanced growth. In addition, the gene is stably incorporated into the germ line, making the phenotype heritable. Because of the scientific importance and potential economic value of transgenic livestock containing foreign genes, we initiated studies on large animals by microinjecting the fusion gene, MT-hGH, into the pronuclei or nuclei of eggs from superovulated rabbits, sheep and pigs. We report here integration of the gene in all three species and expression of the gene in transgenic rabbits and pigs.

The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining

Abstract: In this study, the joining sequences between chromosomes 14 and 18 on the 14q+ chromosomes of a patient with pre-B-cell leukemia and four patients with follicular lymphoma carrying a t(14;18) chromosome translocation were analyzed. In each case, the involved segment of chromosome 18 has recombined with the immunoglobulin heavy-chain joining segment (JH) on chromosome 14. The sites of the recombination on chromosome 14 are located close to the 5' end of the involved JH segment, where the diversity (D) regions are rearranged with the JH segments in the production of active heavy-chain genes. As extraneous nucleotides (N regions) were observed at joining sites and specific signal-like sequences were detected on chromosome 18 in close proximity to the breakpoints, it is concluded that the t(14;18) chromosome translocation is the result of a mistake during the process of VDJ joining at the pre-B-cell stage of differentiation. The putative recombinase joins separated DNA segments on two different chromosomes instead of joining separated segments on the same chromosome, causing a t(14;18) chromosome translocation in the involved B cells.

In the Name of Eugenics: Genetics and the Uses of Human Heredity

Abstract: Preface, 1995 Preface to the Original Edition I. Francis Galton, Founder of the Faith II. Karl Pearson for Saint Biometrika III. Charles Davenport and the Worship of Great Concepts IV. The Gospel Becomes Popular V. Deterioration and Deficiency VI. Measures of Regeneration VII. Eugenic Enactments VIII. A Coalition of Critics IX. False Biology X. Lionel Penrose and the Colchester Survey XI. A Reform Eugenics XII. Brave New Biology XIII. The Establishment of Human Genetics XIV. Apogee of the English School XV. Blood, Big Science, and Biochemistry XVI. Chromosomes-the Binder's Mistakes XVII. A New Eugenics XVIII. Varieties of Presumptuousness XIX. Songs of Deicide Notes Essay on Sources Acknowledgements Index

Peptic ulcer disease.

Abstract: In the final paragraph of that classical volume, \"Peptic Ulcer\" (1) published in 1951, during an era when medical treatment consisted only of special diet and antacids, three of the most eminent gastrointestinal physicians the world has ever known, namely A. C. Ivy, Morton Grossman and William Bachrach, looked towards the future treatment of ulcer. They expressed the hope that \"mutilating operations will be unnecessary\" and predicted that \"future research will reveal orally-active innocuous substances for specifically preventing the formation of acid by the parietal cells and/or rendering the gastric and duodenal mucosa less susceptible to injury\". Over the thirty years which have elapsed since these postulates were put forward many of their requirements have been fulfilled. Certainly, fewer and less mutilating operations are being performed with minimal mortalities but there are still significant and irreversible complications and the chances of ulcer recurrence are appreciable. In the last two decades pharmacological research has achieved the first postulate by developing orally administered agents, now given once daily, which are capable of \"specifically preventing the formation of acid by the parietal cell\". Initially, vagal blockage was attempted with anticholinergics but these were only partially effective and they produced unpleasant side-effects. This state of affairs has been much improved by the development of new muscarine M 1-receptor antagonists such as pirenzepine, which are capable of healing ulcers and have minimal side-effects. There was widespread disappointment when the antihistamine drugs developed in the 1950s were

Robust techniques for signal processing: A survey

Abstract: In recent years there has been much interest in robustness issues in general and in robust signal processing schemes in particular. Robust schemes are useful in situations where imprecise a priori knowledge of input characteristics makes the sensitivity of performance to deviations from assumed conditions an important factor in the design of good signal processing schemes. In this survey we discuss the minimax approach for the design of robust methods for signal processing. This has proven to be a very useful approach because it leads to constructive procedures for designing robust schemes. Our emphasis is on the contributions which have been made in robust signal processing, although key results of other robust statistical procedures are also considered. Most of the results we survey have been obtained in the past fifteen years, although some interesting earlier ideas for minimax signal processing are also mentioned. This survey is organized into five main parts, which deal separately with robust linear filters for signal estimation, robust linear filters for signal detection and related applications, nonlinear methods for robust signal detection, nonlinear methods for robust estimation, and robust data quantization. The interrelationships among many of these results are also discussed in the survey.

“Polyaniline”: Interconversion of Metallic and Insulating Forms

Abstract: “Polyaniline” has been synthesized in various forms both chemically and electrochemically in aqueous media. The qulnoid-benzenoid-diimine form, an insulator, is doped by dilute aqueous protonic acids to the metallic regime ([sgrave] = 5 ohm−1cm−1; compressed pellet) to give the corresponding iminium salt. This represents a new type of p-doping phenomenon in a conducting polymer. Both these forms are stable in the presence of air and/or water. The doping process is reversed by treatment with aqueous alkali. Cyclic voltammetry studies in an aqueous electrolyte show excellent reversibility between selected reduced and oxidized forms of polyaniline.

The Molecular Basis of Cancer

Abstract: Malignant Transformation Growth and Spread of Cancer Molecular Abnormalities in Specific Malignancies, Molecular Basis of Cancer Therapy.

Optical implementation of the Hopfield model.

Abstract: Optical implementation of content addressable associative memory based on the Hopfield model for neural networks and on the addition of nonlinear iterative feedback to a vector–matrix multiplier is described. Numerical and experimental results presented show that the approach is capable of introducing accuracy and robustness to optical processing while maintaining the traditional advantages of optics, namely, parallelism and massive interconnection capability. Moreover a potentially useful link between neural processing and optics that can be of interest in pattern recognition and machine vision is established.

Consistency in a partitioned network: a survey

Abstract: Recently, several strategies have been proposed for transaction processing in partitioned distributed database systems with replicated data. These strategies are surveyed in light of the competing goals of maintaining correctness and achieving high availability. Extensions and combinations are then discussed, and guidelines are presented for selecting strategies for particular applications.

Structure of rapidly quenched Al-Mn.

Abstract: We report electron-microscopy and high-resolution x-ray-scattering measurements of rapidly quenched ${\mathrm{Al}}_{6}$Mn. The electron-diffraction pattern shows icosahedral symmetry. Peaks in the x-ray-diffraction pattern can be indexed to a mixture of fcc Al and a phase whose reciprocal lattice is described by a sum of icosahedral vectors. The half-width of the sharpest x-ray peak is 0.01 ${\mathrm{\AA{}}}^{\ensuremath{-}1}$. A comparison is made with current theories of quasicrystalline order.

The central neural connections of the area postrema of the rat.

Abstract: We applied the neuroanatomical tracers cholera toxin-horseradish peroxidase and wheat germ agglutinin-horseradish peroxidase to investigate the neural connections of the area postrema (AP) in the rat. We find that the AP projects to the nucleus of the solitary tract (NTS) and dorsal motor nucleus of the vagus bilaterally both rostral and caudal to obex; the nucleus ambiguus; the dorsal aspect of the spinal trigeminal tract and nucelus and the paratrigeminal nucleus; the region of the ventrolateral medullary catecholaminergic column; the cerebellar vermis; and a cluster of structures in the dorsolateral pons which prominently include a discrete set of subnuclei in the lateral parabrachial nucleus. The major central afferent input to the area postrema is provided by a group of neurons in the paraventricular and dorsomedial hypothalamic nuclei whose collective dendrites describe a horizontally oriented plexus which encircles the parvocellular nucleus of the hypothalamus bilaterally. In addition, the caudal NTS may project lightly to the AP. The lateral parabrachial nucleus provides a very light input as well. These connections, when considered in the context of the known vagal afferent input and reduced blood-brain barrier of AP, place this structure in a unique position to receive and modulate ascending interoceptive information and to influence autonomic outflow as well.

The central organization of the vagus nerve innervating the stomach of the rat.

Abstract: We employed the neural tracers cholera toxin-horseradish peroxidase and wheat germ agglutinin-horseradish peroxidase to examine the organization of the afferent and efferent connections of the stomach within the medulla oblongata of the rat. The major finding of this study is that gastric motoneurons of the dorsal motor nucleus (DMN) possess numerous dendrites penetrating discrete regions of the overlying nucleus of the solitary tract (NTS). In particular, dendritic labelling was present in areas of NTS which also received terminals of gastric vagal afferent fibers such as the subnucleus gelatinosus, nucleus commissuralis, and medial nucleus of NTS. This codistribution of afferent and efferent elements of the gastric vagus may provide loci for monosynaptic vagovagal interactions. A small number of dendrites of DMN neurons penetrated the ependyma of the fourth ventricle and a few others entered the ventral aspect of the area postrema, thus making possible the direct contact of preganglionic neurons with humoral input from the cerebrospinal fluid and/or the peripheral plasma. Nucleus ambiguus neurons projecting to the stomach predominantly innervate the forestomach. The dendrites of these cells, when labelled, were generally short, and extended beyond the compact cluster of ambiguus neurons in a ventrolateral direction, parallel to the fascicles of vagal efferent fibers traversing the medulla.

Electrochemical Characteristics of “Polyaniline” Cathodes and Anodes in Aqueous Electrolytes

Abstract: The quinoid-benzenoid-diimine form, (=(C6H4)=N-(C6H4)-N=)x of “polyaniline” shows excellent cathode characteristics including recyclability when used in conjunction with a zinc anode in an aqueous electrolyte of (l. 0M ZnCl2 + 0. 5M NH4Cl) having a pH of ∼ 4. The reduced form of this material, (-(C6H4)-N(H)-(C6H4)-N(H)-)x can be used as an anode in conjunction with a Pb02 cathode in an aqueous 0.5M Pb(BF4)2 electrolyte.

Glucose metabolic rate kinetic model parameter determination in humans: the lumped constants and rate constants for [18F]fluorodeoxyglucose and [11C]deoxyglucose.

Abstract: The rate constants and lumped constants (LCs) for [18F]fluorodeoxyglucose ([18F]FDG) and [11C]deoxyglucose ([11C]DG) were determined in humans for the glucose metabolic rate kinetic model used to measure local cerebral glucose consumption. The mean values (±SE) of the LCs for [18F]FDG and [11C]DG are 0.52 ± 0.028 (n = 9) and 0.56 ± 0.043 (n = 6), respectively. The mean values (±SE) of the rate constants k*1, k*2, k*3, and k*4 for [18F]FDG for gray matter are 0.095 ± 0.005, 0.125 ± 0.002, 0.069 ± 0.002, and 0.0055 ± 0.0003, respectively. The corresponding values for white matter are 0.065 ± 0.005, 0.126 ± 0.003, 0.066 ± 0.002, and 0.0054 ± 0.0006, respectively. Using these values and previously published values for the rate constants for [11C]DG, the average whole-brain metabolic rates for glucose in normal subjects measured with [18F]FDG and [11C]DG are 5.66 ± 0.37 (n = 6) and 4.99 ± 0.23 (n = 6) mg/100 g/min, respectively. These values are not significantly different (t = 1.56, p > 0.10) and agree well w...

Clustering of breakpoints on chromosome 11 in human B-cell neoplasms with the t(11;14) chromosome translocation.

Abstract: The t(11;14) (q13;q32) chromosome translocation has been reported in diffuse small and large cell lymphomas and in chronic lymphocytic leukaemia (B-CLL) and multiple myeloma. Because chromosome band 14q32 is involved in this translocation, as well as in the t(8;14) (q24;q32) translocation of the Burkitt tumour, interruption of the immunoglobulin heavy-chain locus was postulated for this rearrangement. We have cloned the chromosomal joinings between chromosomes 11 and 14 and also between chromosomes 14 and 18, in B-cell tumours carrying translocations involving these chromosomes, and suggested the existence of two translocated loci, bcl-1 and bcl-2, normally located on chromosomes 11 (band q13) and 18 (band q21) respectively, involved in the pathogenesis of human B-cell neoplasms. The results indicate that in the leukaemic cells from two different cases of CLL, the breakpoints on chromosome 11 are within 8 nucleotides of each other and on chromosome 14 involve the J4-DNA segment. Because we detected a 7mer-9mer signal-like sequence with a 12-base-long spacer on the normal chromosome 11, close to the breakpoint, we speculate that the t(11;14) chromosome translocation in CLL may be sequence specific and may involve the recombination system for immunoglobulin gene segment (V-D-J) joining.

Crossover effects in the theory of reasoned action: A moderating influence attempt.

Abstract: Both cognitive and normative structure crossover linkages in the Fishbein and Ajzen behavioral intention model were hypothesized on the basis of nine separate predictions taken from the persuasion and false consensus literatures. In a study of new product trial behavior, a maximum likelihood estimation of the model parameters revealed that the normative structure → attitude path was robust under all data subsets, contrary to the hypothesized relationships. The findings support other recent data suggesting attitudinal dependence on social influence.

Generalized median filtering and related nonlinear filtering techniques

Abstract: We consider some generalizations of median filters which combine properties of both the linear and median filters. In particular, L filters and M filters are considered, motivated by robust estimators which are generalizations of the median as a location estimator. A related filter, which we call the modified trimmed mean (MTM) filter, is also described. The filters are evaluated for their performance on noisy signals containing sharp discontinuities or edges. It is shown that M filters can offer a more favorable combination of the running mean and median filters than can L filters, while MTM filters generally have better characteristics than M filters. We also show that an MTM filter is a data-dependent modification of L filters. The concept of double-window filtering is introduced as a refinement of MTM filtering. One representative set of filtered sequences of a test input using these filters are presented to illustrate the performance characterisics of these filters.