University of Peradeniya

About: University of Peradeniya is a education organization based out in Kandy, Sri Lanka. It is known for research contribution in the topics: Population & Poison control. The organization has 5970 authors who have published 7388 publications receiving 197002 citations.

Modeling of Event and Continuous Flow Hydrographs with HEC–HMS: Case Study in the Kelani River Basin, Sri Lanka

Abstract: This paper describes a case study of event and continuous hydrologic modeling in the Kelani River basin in Sri Lanka using the Hydrologic Engineering Center—Hydrologic Modeling System (HEC–HMS). An extremely high rainfall event in November 2005 was used to calibrate model parameters, and extremely high rainfall events in April–May 2008, May–June 2008, and May 2010 were used to validate the event model. The calibrated, direct runoff and base flow parameters were then used in the continuous hydrologic model. The Green and Ampt infiltration loss method was used to account for infiltration loss in event-based modeling and a five-layer soil moisture accounting loss method was employed in continuous modeling. The Clark unit hydrograph method and the recession base flow method were used to simulate direct runoff and base flow, respectively. The results depict the capability of HEC–HMS to reproduce streamflows in the basin to a high accuracy with averaged computed Nash–Sutcliffe efficiencies of 0.91 for e...

Reviewing the world's edible mushroom species: A new evidence-based classification system

Abstract: Wild mushrooms are a vital source of income and nutrition for many poor communities and of value to recreational foragers. Literature relating to the edibility of mushroom species continues to expand, driven by an increasing demand for wild mushrooms, a wider interest in foraging, and the study of traditional foods. Although numerous case reports have been published on edible mushrooms, doubt and confusion persist regarding which species are safe and suitable to consume. Case reports often differ, and the evidence supporting the stated properties of mushrooms can be incomplete or ambiguous. The need for greater clarity on edible species is further underlined by increases in mushroom-related poisonings. We propose a system for categorizing mushroom species and assigning a final edibility status. Using this system, we reviewed 2,786 mushroom species from 99 countries, accessing 9,783 case reports, from over 1,100 sources. We identified 2,189 edible species, of which 2,006 can be consumed safely, and a further 183 species which required some form of pretreatment prior to safe consumption or were associated with allergic reactions by some. We identified 471 species of uncertain edibility because of missing or incomplete evidence of consumption, and 76 unconfirmed species because of unresolved, differing opinions on edibility and toxicity. This is the most comprehensive list of edible mushrooms available to date, demonstrating the huge number of mushrooms species consumed. Our review highlights the need for further information on uncertain and clash species, and the need to present evidence in a clear, unambiguous, and consistent manner.

Suppression of NF-κB Increases Bone Formation and Ameliorates Osteopenia in Ovariectomized Mice

Abstract: Bone degenerative diseases, including osteoporosis, impair the fine balance between osteoclast bone resorption and osteoblast bone formation. Single-agent therapy for anabolic and anticatabolic effects is attractive as a drug target to ameliorate such conditions. Inhibition of nuclear factor (NF)-κB reduces the osteoclast bone resorption. The role of NF-κB inhibitors on osteoblasts and bone formation, however, is minimal and not well investigated. Using an established NF-κB inhibitor named S1627, we demonstrated that inhibition of NF-κB increases osteoblast differentiation and bone formation in vitro by up-regulating the mRNAs of osteoblast-specific genes like type I collagen, alkaline phosphatase, and osteopontin. In addition, S1627 was able to increase bone formation and repair bone defect in a murine calvarial defect model. To determine the effect of NF-κB on a model of osteoporosis, we injected two doses of inhibitor (25 and 50 mg/kg · d) twice a day in sham-operated or ovariectomized 12-wk-old mice a...

Influence of Under Sleeper Pads on Ballast Behavior Under Cyclic Loading: Experimental and Numerical Studies

Abstract: Railway industries are placing greater emphasis on implementing fast and heavy haul corridors for bulk freight and commuter transport in order to deliver more efficient and cost-effective s...