University of Perugia

About: University of Perugia is a education organization based out in Perugia, Umbria, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 13365 authors who have published 39516 publications receiving 1265601 citations. The organization is also known as: Universitá degli Studi di Perugia & Universita degli Studi di Perugia.

Melatonin signaling and cell protection function

Abstract: Besides its well-known regulatory role on circadian rhythm, the pineal gland hormone melatonin has other biological functions and a distinct metabolism in various cell types and peripheral tissues. In different tissues and organs, melatonin has been described to act as a paracrine and also as an intracrine and autocrine agent with overall homeostatic functions and pleiotropic effects that include cell protection and prosurvival factor. These latter effects, documented in a number of in vitro and in vivo studies, are sustained through both receptor-dependent and -independent mechanisms that control detoxification and stress response genes, thus conferring protection against a number of xenobiotics and endobiotics produced by acute and chronic noxious stimuli. Redox-sensitive components are included in the cell protection signaling of melatonin and in the resulting transcriptional response that involves the control of NF-κB, AP-1, and Nrf2. By these pathways, melatonin stimulates the expression of antioxidant and detoxification genes, acting in turn as a glutathione system enhancer. A further and converging mechanism of cell protection by this indoleamine described in different models seems to lie in the control of damage and signaling function of mitochondria that involves decreased production of reactive oxygen species and activation of the antiapoptotic and redox-sensitive element Bcl2. Recent evidence suggests that upstream components in this mitochondrial route include the calmodulin pathway with its central role in melatonin signaling and the survival-promoting component of MAPKs, ERK1/2. In this review article, we will discuss these and other molecular aspects of melatonin signaling relevant to cell protection and survival mechanisms.

Search for supersymmetry at the LHC in events with jets and missing transverse energy

Abstract: A search for events with jets and missing transverse energy is performed in a data sample of pp collisions collected at sqrt(s) = 7 TeV by the CMS experiment at the LHC. The analyzed data sample corresponds to an integrated luminosity of 1.14 inverse femtobarns. In this search, a kinematic variable, alphaT, is used as the main discriminator between events with genuine and misreconstructed missing transverse energy. No excess of events over the standard model expectation is found. Exclusion limits in the parameter space of the constrained minimal supersymmetric extension of the standard model are set. In this model, squark masses below 1.1 TeV are excluded at 95% CL. Gluino masses below 1.1 TeV are also ruled out at 95% CL for values of the universal scalar mass parameter below 500 GeV.

Standardization of preanalytical aspects of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: a consensus paper from the Alzheimer's Biomarkers Standardization Initiative.

Abstract: Background Numerous studies show that the cerebrospinal fluid biomarkers total tau (T-tau), tau phosphorylated at threonine 181 (P-tau 181P ), and amyloid-β (1-42) (Aβ 1–42 ) have high diagnostic accuracy for Alzheimer's disease. Variability in concentrations for Aβ 1–42 , T-tau, and P-tau 181P drives the need for standardization. Methods Key issues were identified and discussed before the first meeting of the members of the Alzheimer's Biomarkers Standardization Initiative (ABSI). Subsequent ABSI consensus meetings focused on preanalytical issues. Results Consensus was reached on preanalytical issues such as the effects of fasting, different tube types, centrifugation, time and temperature before storage, storage temperature, repeated freeze/thaw cycles, and length of storage on concentrations of Aβ 1–42 , T-tau, and P-tau 181P in cerebrospinal fluid. Conclusions The consensus reached on preanalytical issues and the recommendations put forward during the ABSI consensus meetings are presented in this paper.

Gamma-ray emission from the shell of supernova remnant W44 revealed by the Fermi LAT

Abstract: Recent observations of supernova remnants (SNRs) hint that they accelerate cosmic rays to energies close to ~1015 electron volts. However, the nature of the particles that produce the emission remains ambiguous. We report observations of SNR W44 with the Fermi Large Area Telescope at energies between 2 × 108 electron volts and 3 × 1011 electron volts. The detection of a source with a morphology corresponding to the SNR shell implies that the emission is produced by particles accelerated there. The gamma-ray spectrum is well modeled with emission from protons and nuclei. Its steepening above ~109 electron volts provides a probe with which to study how particle acceleration responds to environmental effects such as shock propagation in dense clouds and how accelerated particles are released into interstellar space.

Inventory of the non‐native flora of Italy

Abstract: In this paper we present a comprehensive inventory of the non‐native vascular flora of Italy, which was produced within the project “A survey of the Italian non‐native flora”, funded by the Italian Ministry for the Environment. Previously published floristic accounts were the main source of information. Historical records were critically revised and integrated with recent literature, data from herbaria and some unpublished information, so as to obtain a complete, up‐to‐date catalogue of the non‐native vascular plant species that occur spontaneously in Italy. The inventory lists 1023 non‐native species and subspecies, which account for 13.4% of all the Italian flora. The Italian non‐native flora was divided, according to its residence time, into 103 archaeophytes and 920 neophytes. According to its current invasion status, it was classified into 437 casual (42.7% of all non‐native) and 524 established taxa, the latter being divided into 361 naturalized non‐invasive (35.3%) and 163 invasive taxa (1...