Wayne State University

About: Wayne State University is a education organization based out in Detroit, Michigan, United States. It is known for research contribution in the topics: Population & Cancer. The organization has 42801 authors who have published 82738 publications receiving 3083713 citations. The organization is also known as: WSU & Wayne University.

Multicenter Clinical Evaluation of the (1→3) β-D-Glucan Assay as an Aid to Diagnosis of Fungal Infections in Humans

Abstract: BACKGROUND Measurement of (1-->3)-beta-D-Glucan (BG) has emerged as an adjunct diagnostic strategy for invasive fungal infections (IFI). METHODS Subjects at 6 clinical sites in the United States were enrolled as either fungal infection-negative subjects (n = 170) or subjects with proven or probable IFI according to European Organization for the Research and Treatment of Cancer/Mycoses Study Group criteria (n = 163). A central laboratory and 4 sites performed assays. A single sample was obtained per patient and was evaluated using an assay to detect serum BG derived from fungal cell walls (range, 0 to > 7000 pg/mL). RESULTS At a cutoff of 60 pg/mL, the sensitivity and specificity of the assay were 69.9% and 87.1%, respectively, with a positive predictive value (PPV) of 83.8% and a negative predictive value (NPV) of 75.1%. At a cutoff value of 80 pg/mL, the sensitivity and specificity were 64.4% and 92.4%, respectively, with a PPV of 89% and an NPV of 73%. Of the 107 patients with proven candidiasis, 81.3% had positive results at a cutoff value of 60 pg/mL, and 77.6% had positive results at a cutoff value of 80 pg/mL. Of the 10 patients with aspergillosis, 80% had positive results at cutoff values of 60 and 80 pg/mL. The 3 subjects diagnosed with Fusarium species had positive results at a cutoff value of 60 pg/mL. Patients infected with Mucor or Rhizopus species (both of which lack BG) had negative results at both cutoff values, and of the 12 patients with Cryptococcus infection, 3 had positive results at a cutoff value of 60 pg/mL, and 2 had positive results at a cutoff value of 80 pg/mL. Of the subjects with proven positive results who were receiving antifungal therapy (n = 118), 72.9% had results positive for BG at a cutoff value of 60 pg/mL, and 69.5% had results positive for BG at a cutoff value of 80 pg/mL. The interlaboratory sample test r2 was 0.93. CONCLUSION Reproducible assay results with high specificity and high PPV in a multicenter setting demonstrate that use of an assay to detect serum BG derived from fungal cell walls is a useful diagnostic adjunct for IFI.

Research challenges in wireless networks of biomedical sensors

Abstract: Implanted biomedical devices have the potential to revolutionize medicine. Smart sensors, which are created by combining sensing materials with integrated circuitry, are being considered for several biomedical applications such as a glucose level monitor or a retina prosthesis. These devices require the capability to communicate with an external computer system (base station) via a wireless interface. The limited power and computational capabilities of smart sensor based biological implants present research challenges in several aspects of wireless networking due to the need for having a bio-compatible, fault-tolerant, energy-efficient, and scalable design. Further, em bedding thesesensors in humans add additional requirements. For example, the wireless networking solutions should be ultra-safe and reliable, work trouble-free in different geographical locations (although implants are typically not expected to move; they shouldn't restrict the movements of their human host), and require minimal maintenance. This necessitates application-specific solutions which are vastly different from traditional solutions.In this paper, we describe the potential of biomedical smart sensors. We then explain the challenges for wireless networking of human-embedded smart sensor arrays and our preliminary approach for wireless networking of a retina prosthesis. Our aim is to motivate vigorous research in this area by illustrating the need for more application-specific and novel approaches toward developing wireless networking solutions for human-implanted smart sensors.

The language teaching matrix

Abstract: Richards explains how effective language teaching involves a network of interactions between curriculum, methodology, teachers, learners, instructional materials. Each chapter discusses and examines the theoretical and practical dimensions of a central issue in language teaching. Topics covered include the nature of effective teaching, self-monitoring in teacher development, language and content, and teaching listening, speaking, reading and writing. Richards presents key issues in an accessible and highly readable style, and shows how teachers and teachers-in-training can be involved in the investigation of classroom teaching and learning. The emphasis is not on prescriptions but rather on developing effective teaching through understanding the various factors that interact in second language learning and in the second language classroom.

New trends in solid-phase extraction

Abstract: Solid-phase extraction using cartridge and disc devices is a widely used sample-preparation technique for isolation, concentration, clean-up and medium exchange. To meet the varied needs of contemporary applications, there is available an ever-increasing range of sorbent chemistries based on inorganic oxides, low-specificity (chemically bonded, porous polymer and carbon) and compound and group-selective (ion exchange, mixed mode, macrocyclic, restricted access, immunoaffinity and molecularly imprinted polymer) materials. Advanced device formats facilitate processing of problem samples combined with a high level of automation. Approaches to computer-aided method development promise to replace tedious trial-and-error procedures with fast simulations based on suitable kinetic and retention models.