Institution
Weizmann Institute of Science
Education•Rehovot, Israel•
About: Weizmann Institute of Science is a education organization based out in Rehovot, Israel. It is known for research contribution in the topics: Population & Gene. The organization has 21942 authors who have published 54561 publications receiving 3032812 citations. The organization is also known as: Bessie F. Lawrence International Summer Science Institute & Weitzman Institute.
Topics: Population, Gene, Antigen, Receptor, Immune system
Papers published on a yearly basis
Papers
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TL;DR: It is proposed that the Mdm2-promoted degradation of p53 provides a new mechanism to ensure effective termination of the p53 signal.
Abstract: The p53 tumour-suppressor protein exerts antiproliferative effects, including growth arrest and apoptosis, in response to various types of stress. The activity of p53 is abrogated by mutations that occur frequently in tumours, as well as by several viral and cellular proteins. The Mdm2 oncoprotein is a potent inhibitor of p53. Mdm2 binds the transcriptional activation domain of p53 and blocks its ability to regulate target genes and to exert antiproliferative effects. On the other hand, p53 activates the expression of the mdm2 gene in an autoregulatory feedback loop. The interval between p53 activation and consequent Mdm2 accumulation defines a time window during which p53 exerts its effects. We now report that Mdm2 also promotes the rapid degradation of p53 under conditions in which p53 is otherwise stabilized. This effect of Mdm2 requires binding of p53; moreover, a small domain of p53, encompassing the Mdm2-binding site, confers Mdm2-dependent detstabilization upon heterologous proteins. Raised amounts of Mdm2 strongly repress mutant p53 accumulation in tumour-derived cells. During recovery from DNA damage, maximal Mdm2 induction coincides with rapid p53 loss. We propose that the Mdm2-promoted degradation of p53 provides a new mechanism to ensure effective termination of the p53 signal.
4,311 citations
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University of Zurich1, University of California, Berkeley2, Lawrence Berkeley National Laboratory3, Max Planck Society4, University of Oldenburg5, Leibniz University of Hanover6, University of Antwerp7, Oregon State University8, Technische Universität München9, Cornell University10, Newcastle University11, University of Florence12, Weizmann Institute of Science13
TL;DR: In this article, a new generation of experiments and soil carbon models were proposed to predict the SOM response to global warming, and they showed that molecular structure alone alone does not control SOM stability.
Abstract: Globally, soil organic matter (SOM) contains more than three times as much carbon as either the atmosphere or terrestrial vegetation. Yet it remains largely unknown why some SOM persists for millennia whereas other SOM decomposes readily—and this limits our ability to predict how soils will respond to climate change. Recent analytical and experimental advances have demonstrated that molecular structure alone does not control SOM stability: in fact, environmental and biological controls predominate. Here we propose ways to include this understanding in a new generation of experiments and soil carbon models, thereby improving predictions of the SOM response to global warming.
4,219 citations
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01 Jan 1987TL;DR: Simple identification and signature schemes which enable any user to prove his identity and the authenticity of his messages to any other user without shared or public keys are described.
Abstract: In this paper we describe simple identification and signature schemes which enable any user to prove his identity and the authenticity of his messages to any other user without shared or public keys. The schemes are provably secure against any known or chosen message attack if factoring is difficult, and typical implementations require only 1% to 4% of the number of modular multiplications required by the RSA scheme. Due to their simplicity, security and speed, these schemes are ideally suited for microprocessor-based devices such as smart cards, personal computers, and remote control systems.
4,193 citations
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TL;DR: The transcriptional landscape of the four human HOX loci is characterized at five base pair resolution in 11 anatomic sites and 231 HOX ncRNAs are identified that extend known transcribed regions by more than 30 kilobases, suggesting transcription of ncRNA may demarcate chromosomal domains of gene silencing at a distance.
4,003 citations
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TL;DR: Electrostatic stabilization is an important factor in increasing the rate of the reaction step that leads to the formation of the carbonium ion intermediate, found in the cleavage of a glycosidic bond by lysozyme.
3,951 citations
Authors
Showing all 22106 results
Name | H-index | Papers | Citations |
---|---|---|---|
Lewis C. Cantley | 196 | 748 | 169037 |
Chris Sander | 178 | 713 | 233287 |
David A. Weitz | 178 | 1038 | 114182 |
Michael I. Jordan | 176 | 1016 | 216204 |
Richard H. Friend | 169 | 1182 | 140032 |
Yang Yang | 164 | 2704 | 144071 |
Aviv Regev | 163 | 640 | 133857 |
Dongyuan Zhao | 160 | 872 | 106451 |
Tobin J. Marks | 159 | 1621 | 111604 |
Klaus Rajewsky | 154 | 504 | 88793 |
Roberto Romero | 151 | 1516 | 108321 |
Rui Zhang | 151 | 2625 | 107917 |
Joseph Schlessinger | 150 | 492 | 98862 |
Mikhail D. Lukin | 146 | 606 | 81034 |
Danny Reinberg | 145 | 342 | 68201 |