Worcester Polytechnic Institute

About: Worcester Polytechnic Institute is a education organization based out in Worcester, Massachusetts, United States. It is known for research contribution in the topics: Computer science & Population. The organization has 6270 authors who have published 12704 publications receiving 332081 citations. The organization is also known as: WPI.

Bioengineering Human Myocardium on Native Extracellular Matrix

Abstract: Rationale:More than 25 million individuals have heart failure worldwide, with ≈4000 patients currently awaiting heart transplantation in the United States. Donor organ shortage and allograft rejection remain major limitations with only ≈2500 hearts transplanted each year. As a theoretical alternative to allotransplantation, patient-derived bioartificial myocardium could provide functional support and ultimately impact the treatment of heart failure. Objective:The objective of this study is to translate previous work to human scale and clinically relevant cells for the bioengineering of functional myocardial tissue based on the combination of human cardiac matrix and human induced pluripotent stem cell–derived cardiomyocytes. Methods and Results:To provide a clinically relevant tissue scaffold, we translated perfusion-decellularization to human scale and obtained biocompatible human acellular cardiac scaffolds with preserved extracellular matrix composition, architecture, and perfusable coronary vasculatur...

Comparison of chondrogensis in static and perfused bioreactor culture.

Abstract: As a result of the low yield of cartilage from primary patient harvests and a high demand for autologous cartilage for reconstructive surgery and structural repair, primary explant cartilage must be augmented by tissue engineering techniques. In this study, chondrocytes seeded on PLLA/PGA scaffolds in static culture and a direct perfusion bioreactor were biochemically and histologically analyzed to determine the effects of fluid flow and media pH on matrix assembly. A gradual media pH change was maintained in the bioreactor within 7.4-6.96 over 2 weeks compared to a more rapid decrease from 7.4 to 6.58 in static culture over 3 days. Seeded scaffolds subjected to 1 microm/s flow demonstrated a 118% increase (p < 0.05) in DNA content, a 184% increase (p < 0.05) in GAG content, and a 155% (p < 0.05) increase in hydroxyproline content compared to static culture. Distinct differences were noted in tissue morphology, including more intense staining for proteoglycans by safranin-O and alignment of cells in the direction of media flow. Culture of chondrocyte seeded matrices thus offers the possibility of rapid in vitro expansion of donor cartilage for the repair of structural defects, tracheal injury, and vascularized tissue damage.

Anonymous communications in mobile ad hoc networks

Abstract: Due to the broadcast nature of radio transmissions, communications in mobile ad hoc networks (MANETs) are more susceptible to malicious traffic analysis. In this paper we propose a novel anonymous on-demand routing protocol, termed MASK, to enable anonymous communications thereby thwarting possible traffic analysis attacks. Based on a new cryptographic concept called pairing, we first propose an anonymous neighborhood authentication protocol which allows neighboring nodes to authenticate each other without revealing their identities. Then utilizing the secret pairwise link identifiers and keys established between neighbors during the neighborhood authentication process, MASK fulfills the routing and packet forwarding tasks nicely without disclosing the identities of participating nodes under a rather strong adversarial model. MASK provides the desirable sender and receiver anonymity, as well as the relationship anonymity of the sender and receiver. It is also resistant to a wide range of adversarial attacks. Moreover, MASK preserves the routing efficiency in contrast to previous proposals. Detailed anonymity analysis and simulation studies are carried out to validate and justify the effectiveness of MASK.

The process of technological competence leveraging

Abstract: Technologies are often amenable to uses for a range of markets, but yet are often underutilized, and consequently not all value is extracted from them. This article presents a longitudinal case study of a firm that successfully applied a fungible technology to products for its served market, but was unable to tap its considerable potential in new markets. The processes of resource allocation and resource transformation inhibited technology leveraging, shaped by the presence of a competence to serve current customers (a customer competence trap) and the lack of a competence to gain access to new customers (a marketing competence gap). Copyright © 2007 John Wiley & Sons, Ltd.