Worcester Polytechnic Institute

About: Worcester Polytechnic Institute is a education organization based out in Worcester, Massachusetts, United States. It is known for research contribution in the topics: Computer science & Population. The organization has 6270 authors who have published 12704 publications receiving 332081 citations. The organization is also known as: WPI.

Environmental sustainability and production: taking the road less travelled

Abstract: The research on production and operations management and its linkage to environmental sustainability has seen growth in recent years. The International Journal of Production Research (IJPR) communi...

The Aesthetics of Management Storytelling A Key to Organizational Learning

Abstract: An aesthetics perspective on storytelling contributes to an understanding of how and why some stories are more effective than others. Three ideas about the nature of aesthetic experience—that it is (1) felt meaning from abductive reasoning, (2) characterized by feelings of connectedness, and (3) enjoyed for its own sake-supply criteria for identifying story quality and suggest how to make stories more effective. This idea of good and bad stories informs every aspect of management storytelling, which we illustrate by reviewing the functions of management storytelling using Mintzberg's taxonomy of the roles of the manager Furthermore, through Mintzberg's taxonomy, we show the contributions of aesthetically strong management stories to organizational learning.

The emerging role of zinc transporters in cellular homeostasis and cancer

Abstract: Zinc is an essential micronutrient that plays a role in the structural or enzymatic functions of many cellular proteins. Cellular zinc homeostasis involves the opposing action of two families of metal transporters: the ZnT (SLC30) family that functions to reduce cytoplasmic zinc concentrations and the ZIP (SLC39) family that functions to increase cytoplasmic zinc concentrations. Fluctuations in intracellular zinc levels mediated by these transporter families affect signaling pathways involved in normal cell development, growth, differentiation and death. Consequently, changes in zinc transporter localization and function resulting in zinc dyshomeostasis have pathophysiological effects. Zinc dyshomeostasis has been implicated in the progression of cancer. Here we review recent progress toward understanding the structural basis for zinc transport by ZnT and ZIP family proteins, as well as highlight the roles of zinc as a signaling molecule in physiological conditions and in various cancers. As zinc is emerging as an important signaling molecule in the development and progression of cancer, the ZnT and ZIP transporters that regulate cellular zinc homeostasis are promising candidates for targeted cancer therapy.