Showing papers in "Clinical Therapeutics in 2007"

TL;DR: In these adult, mainly white patients with persistent hypertriglyceridemia, P-OM3 plus simvastatin and dietary counseling improved non-HDL-C and other lipid and lipoprotein parameters to a greater extent than simVastatin alone.

TL;DR: In this article, the authors determined whether more aggressive vancomycin dosing is associated with greater risk for renal toxicity in patients with health care-associated pneumonia attributed to methicilllin-resistant Staphylococcus aureus (MRSA).

TL;DR: Considering that millions of patients have been prescribed bisphosphonates for the treatment of osteoporosis, the relative prevalence of ONJ in these patients was low and it is not possible to draw further conclusions about the potential association between oral bisph phosphonate use and OnJ in the identified studies.

TL;DR: In patients with T2DM, adjunctive exenatide treatment for 2 years was generally well tolerated and resulted in a sustained reduction of HbA(1c), progressive reduction in weight, and improvements in HOMA-B, blood pressure, and the hepatic injury biomarkers, AST and ALT.

TL;DR: Both exenatide and titrated insulin glargine therapy were associated with similar significant changes from baseline in HbA(1c) (both, -1.36% [0.09%]; P < 0.001); the difference between groups was not statistically significant.

TL;DR: The combination regimens in both studies were associated with significantly greater reductions in MSDBP and MSSBP compared with their individual components and placebo, and a positive dose response was observed for all combinations.

TL;DR: Pregabalin appears to be an effective therapy in patients with diabetic peripheral neuropathy, postherpetic neuralgia, and adults with refractory partial-onset seizures and the available data suggest that pregabalin may be beneficial as an adjunctive therapy in adult patients with GAD or SAD.

TL;DR: First-trimester exposure to paroxetine appears to be associated with a significant increase in the risk for cardiac malformation, and a detection bias cannot be ruled out as contributing to the apparent increased detection of cardiovascular malformation of children exposed in utero to parxetine.

TL;DR: Treatment once daily with the prodrug LDX at doses of 30 to 70 mg appeared to be effective and had a tolerability profile similar to those of currently marketed extended-release stimulants.

TL;DR: 12 weeks of colesevelam treatment were associated with significant reductions in HbA(1c) and in fructosamine and postprandial glucose levels compared with placebo, suggesting that coleseVELam may improve both lipid control and glycemic control in patients with type 2 diabetes.

TL;DR: Dasatinib has a wider spectrum of activity against a broader range of BCR-ABL forms than existing TK inhibitors and may have the potential for use in the management of nonleukemic malignancies.

TL;DR: Although intensive-dose statin therapy was associated with a reduced risk for important CV events, it was also associated with an increased risk for statin-induced adverse events and clinical efficacy outcomes, suggesting moderate-doseStatin therapy may be the most appropriate choice for achieving CV risk reduction in the majority of individuals, whereas intensive- doses may be reserved for those at highest risk.

TL;DR: This uncontrolled, open-label trial was an indefinite-duration extension of a previously reported 5-week randomized study in patients with MS and CNP to establish long-term tolerability and effectiveness profiles for THC/CBD oromucosal spray in CNP associated with MS.

TL;DR: The pharmacologic factors that enhance the clinical relevance of potential drug interactions are examined and the literature on drug interactions involving the most commonly used analgesic preparations in the United States is reviewed.

TL;DR: The efficacy and dose-response relationship of varenicline in Japanese smokers was evaluated and nicotine dependence, craving, withdrawal, and smoking satisfaction were determined by the Minnesota Nicotine Withdrawal Scale, the Brief Questionnaire on Smoking Urges, and the modified Cigarette Evaluation Questionnaire.

TL;DR: Rasagiline was effective both as monotherapy in early PD and as adjunctive treatment in patients with advancing PD and motor fluctuations and has the potential to augment the vasopressor effects of diet-derived tyramine (ie, the "cheese reaction").

TL;DR: Current evidence suggests that observational studies can be conducted using the same exacting and rigorous standards as are used for RCTs, and should be considered as a complementary rather than a rival analytic technique.

TL;DR: Sunitinib is a multiple tyrosine kinase receptor inhibitor approved for the treatment of mRCC and GIST and has anti-tumor activity in patients with breast cancer, neuroendocrine tumors, and non-small cell lung cancer.

TL;DR: Use of strategies to manage TG levels, along with low-density lipoprotein cholesterol levels, is warranted to help reduce the risk of CHD.

TL;DR: Estimating the prevalence of myopathic events, particularly myalgia, myositis, and rhabdomyolysis in a community-based practice among a cohort of subjects with or without diabetes, found statin treatment appeared to be well tolerated in diabetic and nondiabetic patients who used them.

TL;DR: Clinical data supporting the use of RAS inhibitors (ACE inhibitors and ARBs) as monotherapy or combination therapy based on the known role of the RAS in BP regulation and the vascular response to injury is presented, and the implications of the data for future treatment are considered.

TL;DR: Calculated unadjusted hypoglycemia event rates appear to underestimate the differences between glargine and NPH, and in most of the present analyses, unadjusted rates were significantly lower with gl argine than NPH.

TL;DR: The findings of this study indicate that the quality of reporting of RCTs of TCM has improved, but remains poor.

TL;DR: Use of combination therapy with an alpha-blocker and a 5ARI may be of benefit in patients who require immediate relief of symptoms, with discontinuation of the alpha- blocker after several months of therapy.

TL;DR: Adherence measures using automated pharmacy data can identify patients who are nonadherent to their drug treatment regimen and who are more likely to have inadequately controlled BP.

TL;DR: The results suggest that deferasirox had a positive impact on patients' daily lives, and patient-reported satisfaction and convenience were significantly higher for the once-daily, oral ICT defer asirox than for DFO infusions.

TL;DR: Varenicline was an efficacious and well-tolerated pharmacotherapy for smoking cessation in this group of Asian smokers over a 12-week treatment period, and its effects persisted for a further 12- weeks follow-up period.

TL;DR: The results from the present analysis support conclusions from previous meta-analyses that cholesterol lowering is clinically beneficial in patients with CHD or at elevated CHD risk and support the previous finding that non-CHD-related mortality is unrelated to lipid reductions.

TL;DR: These post hoc results suggest that duloxetine was effective and well tolerated for the management of DPNP and further support the importance of dulxetine as a treatment option for clinicians and patients to assist with the management.

TL;DR: Posaconazole suspension administered at up to 800 mg/d is a reasonable alternative to conventional antifungal agents for the prevention and treatment of IFIs in high-risk populations.