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Open AccessJournal ArticleDOI

6-Substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives in a new approach of the treatment of cancer cell invasion and metastasis

I. Kempen, +9 more
- 01 Dec 2008 - 
- Vol. 43, Iss: 12, pp 2735-2750
TLDR
Novel 6-substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives were synthesized and their potency in reducing the invasive behaviour of HT 1080 fibrosarcoma cells was evaluated.
About: 
This article is published in European Journal of Medicinal Chemistry.The article was published on 2008-12-01 and is currently open access. It has received 48 citations till now. The article focuses on the topics: Aryl & Thioester.

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Journal ArticleDOI

A Primary Amide-Functionalized Heterogeneous Catalyst for the Synthesis of Coumarin-3-carboxylic Acids via a Tandem Reaction.

Datta Markad, +2 more
- 27 Jul 2020 - 
TL;DR: Based on the optimized conditions, it is determined that 1 is highly efficient and its recyclability up to five cycles without significant loss of activity and structural integrity is also demonstrated.
Journal ArticleDOI

Synthesis and Crystal Structure of 4,7‐Diaryl‐5‐oxo‐4H‐benzo[b]pyran Derivatives

Bin Cui, +4 more
- 01 Jul 2012 - 
TL;DR: A green and convenient approach to the synthesis of a series of 4,7-diaryl-5-oxo-4H-benzo[b]pyran derivatives from appropriate aromatic aldehydes and 5-aryl-1,3-cyclohexanedione with malononitrile as catalyst (30 mmol/L) is described in this article.
Journal ArticleDOI

Synthesis, structure elucidation, DNA-PK, PI3K, anti-platelet and anti-bacteria activity of linear 5, 6, and 10-substituted-2-morpholino-chromen-oxazine-dione and angular 3, 4, 6-substituted-8-morpholino-chromen-oxazine-2,10-dione

Rick Morrison, +1 more
- 02 Jun 2016 - 
TL;DR: Coumarin, a naturally occurring or synthesised phytochemical, displays a wide range of biological activities, but chromen-2-ones fused with 1,3-benzoxazine rings is not well documented and there is a gap in the literature which required engaging.
Journal ArticleDOI

Aqueous-mediated green synthesis of 3-carboxyxoumarins using grinding technique

Dinesh Kumar, +2 more
- 11 Sep 2015 - 
TL;DR: In this paper, a simple and green procedure for the synthesis of 3-carboxycoumarins has been developed which involves the grinding of 2-hydroxybenzaldehydes with Meldrum's acid (2,2-dimethyl-1,3-dioxan-4,6-dione) in aqueous moist conditions at room temperature.
Journal ArticleDOI

An unusual and facile N-hetero cyclisation of 2-amino-4-(2-oxo-2-arylethyl)-4H-chromene-3-carbonitrile derivatives using hypervalent iodine in alcohol under ambient condition

Sourav Mal, +1 more
- 01 Oct 2020 - 
TL;DR: In this article, a very important functionalized benzopyran moiety was further functionalized along with an unusual N-heterocyclic ring formation in a single step under ambient condition in room temperature under the influence of hypervalent iodine to produce a structurally interesting motif which can have some interesting biological properties having a similar but modified structure as that of bio-active chromene moieties.
References
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Journal ArticleDOI

Studies on Coumarins and Coumarin-Related Compounds to Determine their Therapeutic Role in the Treatment of Cancer

Aoife Lacy, +1 more
- 31 Oct 2004 - 
TL;DR: These studies suggest that both genistein and esculetin exerted the most potent inhibitory effect on cell growth in comparison to the other two compounds, which may lead to its use in cancer therapy.
Journal ArticleDOI

Synthetic and natural coumarins as cytotoxic agents.

Irena Kostova
- 01 Jan 2005 - 
TL;DR: There is still a long way to go until the authors know which cytotoxic agent will clinically be suitable for what tumor entity for treatment, because promising data have been reported for a series of these agents, and the results from different coumarins with various tumor lines are contradictory in part.
Journal ArticleDOI

Sunitinib malate for the treatment of solid tumours: a review of current clinical data

Robert J. Motzer, +3 more
- 24 Apr 2006 - 
TL;DR: The present review provides an updated summary of emerging clinical experience with Sunitinib malate, an oral multitargeted tyrosine kinase inhibitor with antitumour and antiangiogenic activity that recently received approval from the FDA.
Journal Article

Antiangiogenic Effects of the Quinoline-3-Carboxamide Linomide

Jasminka Vukanovic, +5 more
- 15 Apr 1993 - 
TL;DR: It was demonstrated that due to its antiangiogenic activity, linomide treatment of rats bearing prostate cancers resulted in a more than 40% decrease in tumor blood flow and blood flow to a variety of non-tumor bearing organs was not decreased suggesting that linomides selectively inhibits angiogenesis and does not induce loss of established blood vessels.
Journal ArticleDOI

Current status of angiogenesis inhibitors combined with radiation therapy

Carsten Nieder, +3 more
- 01 Aug 2006 - 
TL;DR: Early results suggest that acute toxicity is acceptable, planned surgery after such treatment is feasible, and that further evaluation of such combined modality treatment is warranted.
Related Papers (5)

3-Bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate inhibits cancer cell invasion in vitro and tumour growth in vivo.

I. Kempen, +9 more
- 07 Apr 2003 - 

Ketocoumarins: A new class of triplet sensitizers

Dnolad P. Specht, +2 more
- 01 Jan 1982 - 

Uncatalysed reactions in water: Part 2. Preparation of 3-carboxycoumarins

Raimondo Maggi, +4 more
- 01 Jan 2001 - 

Synthesis, selective anti-Helicobacter pylori activity, and cytotoxicity of novel N-substituted-2-oxo-2H-1-benzopyran-3-carboxamides.

Franco Chimenti, +10 more
- 15 Aug 2010 - 

Pharmacological and biochemical actions of simple coumarins : Natural products with therapeutic potential

J. R. S. Hoult, +1 more
- 01 Jun 1996 - 
Frequently Asked Questions (1)
Q1. What are the contributions in "6-substituted 2-oxo-2h-1-benzopyran-3-carboxylic acid derivatives in a new approach of the treatment of cancer cell invasion and metastasis" ?

This work confirms the interest of aryl esters of 6-substituted coumarin-3-carboxylic acids as potential new anticancer agents.