A broadly active fucosyltransferase LmjFUT1 whose mitochondrial localization and catalytic activity is essential in the parasitic protozoan Leishmania
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References
Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major
Improvements in transfection efficiency and tests of RNA interference (RNAi) approaches in the protozoan parasite Leishmania.
Human symbionts use a host-like pathway for surface fucosylation.
Secretory Pathway of Trypanosomatid Parasites
A Role for Insect Galectins in Parasite Survival
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Frequently Asked Questions (2)
Q2. What have the authors stated for future works in "A broadly active fucosyltransferase lmjfut1 whose mitochondrial localization and catalytic activity is essential in the parasitic protozoan leishmania" ?
Future studies will address this possibility. Future studies will be necessary to resolve the nature of the GDP-Fucose and FUT1dependent product ( s ) in trypanosomatids, which genetic and biochemical data strongly predict must nonetheless exist. Potentially, trypanosomatid mitochondrial FUT1s may offer a facile system in the future for probing mitochondrial glycosylation in a setting uncomplicated by multiple isoforms targeted to diverse compartments, and its essentiality renders it an attractive target for chemotherapy of trypanosomatid parasites. L. donovani expresses a mannose-fucose conjugate whose structure has not been definitively established ( 33 ), and several L. donovani proteins exhibited MS/MS signatures suggestive of fucosylation ( 34 ).