Journal ArticleDOI
A Dual-Targeted Organic Photothermal Agent for Enhanced Photothermal Therapy
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TLDR
A dual-targeted organic molecule that functions as a photothermal agent by actively targeting tumor tissue and mitochondria to selectively kill cancer cells is demonstrated.Abstract:
The development of highly effective anticancer drugs that cause minimal damage to the surrounding normal tissues is a challenging topic in cancer therapy. Herein, we demonstrate a dual-targeted organic molecule that functions as a photothermal agent by actively targeting tumor tissue and mitochondria to selectively kill cancer cells. The synthesized photothermal agent exhibited high photothermal conversion efficiency, low cytotoxicity, and good biological compatibility. In vivo experiments showed an excellent tumor inhibitory effect of the dual-targeted photothermal agent.read more
Citations
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Journal ArticleDOI
Single-Atom Pd Nanozyme for Ferroptosis-Boosted Mild-Temperature Photothermal Therapy
Mengyu Chang,Mengyu Chang,Zhiyao Hou,Man Wang,Chunzheng Yang,Chunzheng Yang,Ruifeng Wang,Fang Li,Donglian Liu,Tieli Peng,Chunxia Li,Jun Lin,Jun Lin +12 more
TL;DR: In this article, a single-atom nanozyme (SAzyme) based mild-temperature photothermal therapy (PTT) was proposed to increase the efficiency and minimize the damage to healthy tissues simultaneously by adopting appropriate therapeutic temperatures.
Journal ArticleDOI
Supramolecular Photothermal Effects: A Promising Mechanism for Efficient Thermal Conversion.
TL;DR: The emphasis is placed on the inherent physiochemical mechanisms of these materials, including quenching fluorescence, controlling intramolecular motion, enhancing the absorption intensity, and increasing the stability, which refer to the unique features of supramolescular chemistry for regulating photothermal conversion efficiency.
Journal ArticleDOI
Recent Advances in Hyperthermia Therapy-Based Synergistic Immunotherapy.
TL;DR: The synergistic mechanism of HTT in immunotherapy, including immunogenic cell death and reversal of the immunosuppressive tumor microenvironment is discussed, and these strategies could achieve synergistically enhanced therapeutic outcomes against both primary tumors and metastatic lesions, prevent cancer recurrence, and prolong the survival period.
Journal ArticleDOI
Boosting Cancer Therapy with Organelle-Targeted Nanomaterials.
TL;DR: In this review, the design principles, targeting strategies, therapeutic mechanisms, current challenges and potential future directions of organelle-targeted nanomaterials will be introduced.
Journal ArticleDOI
An Ultrasmall SnFe2O4 Nanozyme with Endogenous Oxygen Generation and Glutathione Depletion for Synergistic Cancer Therapy
Lili Feng,Bin Liu,Rui Xie,Dongdong Wang,Cheng Qian,Weiqiang Zhou,Jiawei Liu,Deblin Jana,Piaoping Yang,Yanli Zhao +9 more
TL;DR: This “all in one” nanozyme integrated with multiple treatment modalities, computed tomography, and magnetic resonance imaging properties, and persistent modulation of TME exhibits excellent tumor theranostic performance.
References
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Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs
Lihong V. Wang,Song Hu +1 more
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Jonathan F. Lovell,Cheng S. Jin,Cheng S. Jin,Elizabeth Huynh,Elizabeth Huynh,Honglin Jin,Honglin Jin,Chulhong Kim,John L. Rubinstein,Warren C. W. Chan,Weiguo Cao,Lihong V. Wang,Gang Zheng,Gang Zheng +13 more
TL;DR: The development of porphysomes; nanovesicles formed from self-assembled porphyrin bilayers that generated large, tunable extinction coefficients, structure-dependent fluorescence self-quenching and unique photothermal and photoacoustic properties demonstrate the multimodal potential of organic nanoparticles for biophotonic imaging and therapy.
Journal ArticleDOI
Organic molecule-based photothermal agents: an expanding photothermal therapy universe
Hyo Sung Jung,Hyo Sung Jung,Peter Verwilst,Amit Sharma,Jinwoo Shin,Jonathan L. Sessler,Jonathan L. Sessler,Jong Seung Kim +7 more
TL;DR: This tutorial review provides a structured description of the main classes of organic photothermal agents and their characteristics and highlights recent advances in using PTT agents to address various cancers indications.
Journal ArticleDOI
Nuclear-targeted drug delivery of TAT peptide-conjugated monodisperse mesoporous silica nanoparticles.
TL;DR: TAT peptide has been employed to conjugate onto mesoporous silica nanoparticles (MSNs-TAT) with high payload for nuclear-targeted drug delivery for the first time, and may provide an effective strategy for the design and development of cell-nuclear-targeting drug delivery.
Journal ArticleDOI
Recent Development of Chemosensors Based on Cyanine Platforms
TL;DR: This review focuses on the development from 2000 to 2015 of cyanine, hemicyanine, and squaraine sensors, and emphasizes the advances that have been made in improving the detection performance through incorporation of the chemosensors into nanoparticles.