A Novel Coronavirus Genome Identified in a Cluster of Pneumonia Cases - Wuhan, China 2019-2020
Wenjie Tan,Xiang Zhao,Xuejun Ma,Wenling Wang,Peihua Niu,Wenbo Xu,George F. Gao,Guizhen Wu,Guizhen Wu +8 more
- Vol. 2, Iss: 4, pp 61-62
Citations
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Risk of nosocomial transmission of coronavirus disease 2019: an experience in a general ward setting in Hong Kong.
TL;DR: The findings suggest that SARS-CoV-2 is not spread by an airborne route, and nosocomial transmissions can be prevented through vigilant basic infection control measures, including wearing of surgical masks, hand and environmental hygiene.
Posted ContentDOI
Estimation of risk factors for COVID-19 mortality - preliminary results
TL;DR: It is found that age is the variable that presents higher risk of COVID-19 mortality, where 60 or older patients have an OR = 18.8161 (CI95%[7.1997; 41.5517]).
Journal ArticleDOI
Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury
Yingxia Liu,Cong Zhang,Cong Zhang,Fengming Huang,Yang Yang,Fuxiang Wang,Jing Yuan,Zheng Zhang,Yuhao Qin,Li Xiaoyun,Dandan Zhao,Shunwang Li,Shuguang Tan,Zhaoqin Wang,Jinxiu Li,Chenguang Shen,Jianming Li,Ling Peng,Weibo Wu,Mengli Cao,Li Xing,Zhixiang Xu,Li Chen,Cong-Zhao Zhou,William J. Liu,Lei Liu,Chengyu Jiang +26 more
TL;DR: It is suggested that 2019-nCoV infections trigger extensive changes in a wide array of cytokines, some of which could be potential biomarkers of disease severity of2019-n coV infections.
Journal ArticleDOI
Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis.
Liming Yan,Ji Ge,Litao Zheng,Ying Zhang,Yan Gao,Tao Wang,Yucen Huang,Yunxiang Yang,Shan Gao,Mingyu Li,Zhenyu Liu,Haofeng Wang,Yingjian Li,Yu Chen,Luke W. Guddat,Quan Wang,Zihe Rao,Zihe Rao,Zhiyong Lou +18 more
TL;DR: A structural snapshot of SARS-CoV-2 RTC as it transition towards cap structure synthesis is presented, paving a way to understand the RTC architecture, and providing a target for antiviral development.
Journal ArticleDOI
Laboratory readiness and response for novel coronavirus (2019-nCoV) in expert laboratories in 30 EU/EEA countries, January 2020.
Chantal B.E.M. Reusken,Eeva Broberg,Bart L. Haagmans,Adam Meijer,Victor M. Corman,Anna Papa,Rémi N. Charrel,Christian Drosten,Marion Koopmans,Katrin Leitmeyer,ERLI-Net +10 more
TL;DR: Assessment of the required expertise and capacity for molecular detection of 2019-nCoV in specialised laboratories in 30 European Union/European Economic Area (EU/EEA) countries found availability of primers/probes, positive controls and personnel were main implementation barriers.
References
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MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability
Kazutaka Katoh,Daron M. Standley +1 more
TL;DR: This version of MAFFT has several new features, including options for adding unaligned sequences into an existing alignment, adjustment of direction in nucleotide alignment, constrained alignment and parallel processing, which were implemented after the previous major update.
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A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood.
Stéphane Guindon,Olivier Gascuel +1 more
TL;DR: This work has used extensive and realistic computer simulations to show that the topological accuracy of this new method is at least as high as that of the existing maximum-likelihood programs and much higher than the performance of distance-based and parsimony approaches.
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From “A”IV to “Z”IKV: Attacks from Emerging and Re-emerging Pathogens
George F. Gao,George F. Gao +1 more
TL;DR: 100 years after the infamous “Spanish flu” pandemic, the 2017–2018 flu season has been severe, with numerous infections worldwide.
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