A Novel Coronavirus Genome Identified in a Cluster of Pneumonia Cases - Wuhan, China 2019-2020
Wenjie Tan,Xiang Zhao,Xuejun Ma,Wenling Wang,Peihua Niu,Wenbo Xu,George F. Gao,Guizhen Wu,Guizhen Wu +8 more
- Vol. 2, Iss: 4, pp 61-62
Citations
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Cross-species recognition of SARS-CoV-2 to bat ACE2.
Kefang Liu,Shuguang Tan,Sheng Niu,Sheng Niu,Jia Wang,Lili Wu,Huan Sun,Yanfang Zhang,Xiaoqian Pan,Xiao Qu,Pei Du,Yumin Meng,Yunfei Jia,Yunfei Jia,Qian Chen,Qian Chen,Chu-Xia Deng,Jinghua Yan,Hong-Wei Wang,Qihui Wang,Jianxun Qi,George F. Gao +21 more
TL;DR: The SARS-CoV-2 spike protein receptor binding domain (RBD) could bind to bACE2 from Rhinolophus macrotis (bACE2-Rm) with substantially lower affinity compared with that to the human ACE2 (hACE2) for virus infection.
Posted ContentDOI
Artificial intelligence-enabled rapid diagnosis of COVID-19 patients.
Xueyan Mei,Hao-Chih Lee,Kaiyue Diao,Mingqian Huang,Bin Lin,Chenyu Liu,Zongyu Xie,Yixuan Ma,Philip M. Robson,Michael H. Chung,Adam Bernheim,Venkatesh Mani,Claudia Calcagno,Kunwei Li,Shaolin Li,Hong Shan,Jian Lv,Tongtong Zhao,Junli Xia,Qihua Long,Sharon Steinberger,Adam Jacobi,Timothy W. Deyer,Marta Luksza,Fang Liu,Brent P. Little,Zahi A. Fayad,Yang Yang +27 more
TL;DR: Artificial intelligence algorithms are used to integrate chest CT findings with clinical symptoms, exposure history, and laboratory testing to rapidly diagnose COVID-19 positive patients and improved the detection of RT-PCR positive CO VID-19 patients who presented with normal CT scans.
Journal ArticleDOI
The 2020 Pandemic: Current SARS-CoV-2 Vaccine Development.
Sana O. Alturki,Sawsan O. Alturki,Jennifer Connors,Gina Cusimano,Michele A. Kutzler,Abdullah M Izmirly,Elias K. Haddad +6 more
TL;DR: In this review, the furthest vaccines in the clinical pipeline are summarized and there is an urgent demand for developing a vaccine since no effective therapies or vaccines have been approved to prevent or minimize the spread of the infection.
Journal ArticleDOI
Performance of a Point-of-Care Test for the Rapid Detection of SARS-CoV-2 Antigen
Annabelle Strömer,Ruben Rose,Miriam Schäfer,Frieda Schön,Anna Vollersen,Thomas Lorentz,Helmut Fickenscher,Andi Krumbholz +7 more
TL;DR: In this paper, a triplex real-time polymerase chain reaction (RT-PCR) was used for the detection of viral nucleoprotein gene and two control targets.
Journal ArticleDOI
Structural basis of human ACE2 higher binding affinity to currently circulating Omicron SARS-CoV-2 sub-variants BA.2 and BA.1.1
Lin-jie Li,Hanyi Liao,Yumin Meng,Weiwei Li,Pengcheng Han,Kefang Liu,Qing Wang,Dedong Li,Yanfang Zhang,Liang Wang,Zheng Fan,Yuqin Zhang,Qiyue Wang,Xin Zhao,Yeping Sun,N. Huang,Jianxun Qi,George F. Gao +17 more
TL;DR: Kandeel et al. as mentioned in this paper found that BA.1.1 and BA.2 have higher binding strength to hACE2 than the prototype and BA1.3.
References
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MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability
Kazutaka Katoh,Daron M. Standley +1 more
TL;DR: This version of MAFFT has several new features, including options for adding unaligned sequences into an existing alignment, adjustment of direction in nucleotide alignment, constrained alignment and parallel processing, which were implemented after the previous major update.
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A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood.
Stéphane Guindon,Olivier Gascuel +1 more
TL;DR: This work has used extensive and realistic computer simulations to show that the topological accuracy of this new method is at least as high as that of the existing maximum-likelihood programs and much higher than the performance of distance-based and parsimony approaches.
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From “A”IV to “Z”IKV: Attacks from Emerging and Re-emerging Pathogens
George F. Gao,George F. Gao +1 more
TL;DR: 100 years after the infamous “Spanish flu” pandemic, the 2017–2018 flu season has been severe, with numerous infections worldwide.
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