A novel restorative pulmonary valved conduit in a chronic sheep model: Mid-term hemodynamic function and histologic assessment.
Ger B.W.E. Bennink,Sho Torii,Marieke Brugmans,Martijn Cox,Oleg Svanidze,Elena Ladich,Thierry Carrel,Renu Virmani +7 more
TLDR
Both conduits demonstrated an acceptable safety and functionality and significant calcification was rarely observed in the XPV, whereas the H developed more neointimal thickness with calcification of the porcine aortic root portion of the wall.About:
This article is published in The Journal of Thoracic and Cardiovascular Surgery.The article was published on 2017-12-21 and is currently open access. It has received 78 citations till now.read more
Citations
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Challenges With the Development of Biomaterials for Sustainable Tissue Engineering
TL;DR: It is argued here that a traditional ‘scaffold’ represents the wrong approach, and that tissue-engineering templates that are designed to replicate the niche, or microenvironment, of these target cells are much more likely to succeed.
Journal ArticleDOI
Next-generation tissue-engineered heart valves with repair, remodelling and regeneration capacity
Emanuela S. Fioretta,Sarah E. Motta,Sarah E. Motta,Valentina Lintas,S Sandra Loerakker,Kevin Kit Parker,Frank P. T. Baaijens,Volkmar Falk,Simon P. Hoerstrup,Maximilian Y. Emmert +9 more
TL;DR: An unmet clinical need remains for valve replacements with regenerative, remodelling and growth potential, and next-generation tissue-engineered heart valves (TEHVs) are a promising therapeutic option for patients with valvular heart disease.
Journal ArticleDOI
Macrophage-Driven Biomaterial Degradation Depends on Scaffold Microarchitecture.
Tamar B Wissing,Valentina Bonito,Eline E. van Haaften,Marina van Doeselaar,Marieke Brugmans,Henk M. Janssen,Carlijn V. C. Bouten,Anthal I.P.M. Smits +7 more
TL;DR: Electrospun poly-ε-caprolactone-bisurea scaffolds with either 2 or 6 μm isotropic or anisotropic fibers were seeded with THP-1 derived human macrophages and cultured in vitro for 4 or 8 days, revealing that macroph age-induced oxidative degradation in particular was dependent on scaffold microarchitecture.
Journal ArticleDOI
Preclinical Assessment of Cardiac Valve Substitutes: Current Status and Considerations for Engineered Tissue Heart Valves
TL;DR: The regulatory framework for regulation of medical devices in general and substitute heart valves in particular is reviewed, and the special challenges of preclinical testing using animal models for TEHV are considered.
Journal ArticleDOI
Can We Grow Valves Inside the Heart? Perspective on Material-based In Situ Heart Valve Tissue Engineering.
TL;DR: It is argued that a combination of basic science – unveiling the mechanisms of the human body to respond to the implanted biomaterial under (patho)physiological conditions – and technological advancements – relating to the development of next generation materials and the prediction of in situ tissue growth and adaptation – is essential to take the next step towards a realistic and rewarding translation ofIn situ heart valve tissue engineering.
References
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Reversible Polymers Formed from Self-Complementary Monomers Using Quadruple Hydrogen Bonding
Rint P. Sijbesma,Felix Hugo Beijer,Felix Hugo Beijer,Luc Brunsveld,Luc Brunsveld,B. J. B. Folmer,B. J. B. Folmer,J. H. K. Ky Hirschberg,J. H. K. Ky Hirschberg,Ronald Frans Maria Lange,Ronald Frans Maria Lange,Jimmy K. L. Lowe,Jimmy K. L. Lowe,E. W. Meijer,E. W. Meijer +14 more
TL;DR: 2-ureido-4-pyrimidone that dimerize strongly in a self-complementary array of four cooperative hydrogen bonds were used as the associating end group in reversible self-assembling polymer systems.
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From supramolecular chemistry towards constitutional dynamic chemistry and adaptive chemistry
TL;DR: Supramolecular chemistry considers chemical objects and systems capable of responding to external solicitations by modification of their constitution through component exchange or reorganisation, and opens the way towards an adaptive and evolutive chemistry, a further step towards the chemistry of complex matter.
Journal ArticleDOI
Functional Living Trileaflet Heart Valves Grown In Vitro
Simon P. Hoerstrup,Ralf Sodian,Sabine Daebritz,Jun Wang,Emile A. Bacha,David P. Martin,Adrian M. Moran,Kristine J. Guleserian,Jason S. Sperling,Sunjay Kaushal,Joseph P. Vacanti,Frederick J. Schoen,John E. Mayer +12 more
TL;DR: In vitro generation of implantable complete living heart valves based on a biomimetic flow culture system that functioned up to 5 months and resembled normal heart valves in microstructure, mechanical properties, and extracellular matrix formation.
Journal ArticleDOI
Late-term results of tissue-engineered vascular grafts in humans
Narutoshi Hibino,Edward A. McGillicuddy,Goki Matsumura,Yuki Ichihara,Yuji Naito,Christopher K. Breuer,Toshiharu Shinoka +6 more
TL;DR: Tissue-engineered vascular grafts can be used as conduits in patients with single ventricle physiology and further follow-up and investigation for the mechanism of stenosis are warranted.
Journal ArticleDOI
Autologous Human Tissue-Engineered Heart Valves Prospects for Systemic Application
Anita Mol,Marcel C. M. Rutten,Niels J. B. Driessen,Carlijn V. C. Bouten,Gregor Zünd,Frank P. T. Baaijens,Simon P. Hoerstrup,Simon P. Hoerstrup +7 more
TL;DR: Tissue properties and mechanical behavior might allow for use as living aortic valve replacements in tissue-engineered heart valves based on human saphenous vein cells and a rapid degrading synthetic scaffold.
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