Journal ArticleDOI
Off-the-shelf human decellularized tissue-engineered heart valves in a non-human primate model
Benedikt Weber,Petra E. Dijkman,Jacques Scherman,Bart Sanders,Maximilian Y. Emmert,Jürg Grünenfelder,Renier Verbeek,Mona Bracher,Melanie Black,Thomas Franz,Jeroen Kortsmit,Peter Modregger,Peter Modregger,Silvia Peter,Silvia Peter,Marco Stampanoni,Marco Stampanoni,Jerome Robert,Debora Kehl,Marina van Doeselaar,Martin Schweiger,Chad Brokopp,Thomas Wälchli,Thomas Wälchli,Volkmar Falk,Peter Zilla,Anita Anita Driessen-Mol,Frank P. T. Baaijens,Simon P. Hoerstrup +28 more
TLDR
The results suggest that human cell-derived bioengineered decellularized materials represent a promising and clinically relevant starter matrix for heart valve tissue engineering and may ultimately overcome the limitations of currently used valve replacements by providing homologous, non-immunogenic, off-the-shelf replacement constructs.About:
This article is published in Biomaterials.The article was published on 2013-10-01. It has received 181 citations till now. The article focuses on the topics: Heart valve & Decellularization.read more
Citations
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Journal ArticleDOI
Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients.
Martin B. Leon,Craig R. Smith,Michael J. Mack,Michael J. Mack,Rajendra Makkar,Lars G. Svensson,Susheel Kodali,Vinod H. Thourani,Murat Tuzcu,D. Craig Miller,Howard C. Herrmann,Darshan Doshi,David J. Cohen,Augusto D. Pichard,Samir R. Kapadia,Todd M. Dewey,Vasilis Babaliaros,Wilson Y. Szeto,Mathew R. Williams,Dean J. Kereiakes,Alan Zajarias,Kevin L. Greason,Brian Whisenant,Robert W. Hodson,Jeffrey W. Moses,Alfredo Trento,David L. Brown,William F. Fearon,Philippe Pibarot,Rebecca T. Hahn,Wael A. Jaber,William N. Anderson,Maria Alu,John G. Webb +33 more
TL;DR: In intermediate-risk patients, TAVR was similar to surgical aortic-valve replacement with respect to the primary end point of death or disabling stroke; surgery resulted in fewer major vascular complications and less paravalvular aorta regurgitation.
Journal ArticleDOI
Advancing biomaterials of human origin for tissue engineering
Fa-Ming Chen,Xiaohua Liu +1 more
TL;DR: An exploration of the structural, mechanical, biochemical and biological information present in native human tissue for bioengineering applications is focused on to provide inspiration for the design of future biomaterials.
Journal ArticleDOI
Extracellular matrix-based materials for regenerative medicine
TL;DR: Challenges and opportunities of ECM biomaterials are investigated for the design of organotypic models to study disease progression, for the ex vivo creation of engineered tissue and for the clinical translation of functional tissue reconstruction strategies in vivo.
Journal ArticleDOI
ECM and ECM-like materials – Biomaterials for applications in regenerative medicine and cancer therapy
Svenja Hinderer,Shannon L. Layland,Katja Schenke-Layland,Katja Schenke-Layland,Katja Schenke-Layland +4 more
TL;DR: This review provides a summary of current approaches that employ ECM and ECM-like materials, orECM-synthetic polymer hybrids, as biomaterials in the field of regenerative medicine and discusses the utilization of such materials for cell and drug delivery, and highlight strategies for their use as vehicles for cancer therapy.
Journal ArticleDOI
In situ heart valve tissue engineering using a bioresorbable elastomeric implant - From material design to 12 months follow-up in sheep.
Jolanda Kluin,Hanna Talacua,Anthal I.P.M. Smits,Maximilian Y. Emmert,Marieke Brugmans,Emanuela S. Fioretta,Petra E. Dijkman,Serge H. M. Söntjens,Renee Duijvelshoff,Sylvia Dekker,Marloes W J T Janssen-van den Broek,Valentina Lintas,Aryan Vink,Simon P. Hoerstrup,Simon P. Hoerstrup,Henk M. Janssen,Patricia Y. W. Dankers,Frank P. T. Baaijens,Carlijn V. C. Bouten +18 more
TL;DR: A fibrous valvular scaffold is designed, fabricated from a novel supramolecular elastomer, that enables endogenous cells to enter and produce matrix and offer new perspectives for endogenous heart valve replacement starting from a readily-available synthetic graft that is compatible with surgical and transcatheter implantation procedures.
References
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Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue
TL;DR: A modified form of the dim methylmethylene blue assay is described that has improved specificity for sulphated glycosaminoglycans, and it is shown that in conjunction with specific polysaccharidases, the dimethylmethyleneblue assay can be used to quantitate individual sulphated sugarcans.
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Improved microfluorometric DNA determination in biological material using 33258 Hoechst
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Journal ArticleDOI
Prosthetic Heart Valves Selection of the Optimal Prosthesis and Long-Term Management
TL;DR: An overview of the current state of knowledge and future perspectives with regard to optimal prosthesis selection and clinical management after valve implantation is provided.
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In situ heart valve tissue engineering using a bioresorbable elastomeric implant - From material design to 12 months follow-up in sheep.
Jolanda Kluin,Hanna Talacua,Anthal I.P.M. Smits,Maximilian Y. Emmert,Marieke Brugmans,Emanuela S. Fioretta,Petra E. Dijkman,Serge H. M. Söntjens,Renee Duijvelshoff,Sylvia Dekker,Marloes W J T Janssen-van den Broek,Valentina Lintas,Aryan Vink,Simon P. Hoerstrup,Simon P. Hoerstrup,Henk M. Janssen,Patricia Y. W. Dankers,Frank P. T. Baaijens,Carlijn V. C. Bouten +18 more