A pilot double-blind safety and feasibility randomized controlled trial of high-dose intravenous zinc in hospitalized COVID-19 patients.
Oneel Patel,Vidyasagar Chinni,John El-Khoury,Marlon Perera,Ary Serpa Neto,Ary Serpa Neto,Christine F McDonald,Emily J See,Daryl A Jones,Daryl A Jones,Damien M Bolton,Rinaldo Bellomo,Rinaldo Bellomo,Jason A Trubiano,Joseph Ischia +14 more
TLDR
In this paper, the safety, feasibility, and biological effect of administering high-dose intravenous zinc (HDIVZn) to patients with COVID-19 was evaluated in a Phase IIa double-blind, randomized controlled trial.Abstract:
Zinc inhibits replication of the SARS-CoV virus. We aimed to evaluate the safety, feasibility, and biological effect of administering high-dose intravenous zinc (HDIVZn) to patients with COVID-19. We performed a Phase IIa double-blind, randomized controlled trial to compare HDIVZn to placebo in hospitalized patients with COVID-19. We administered trial treatment per day for a maximum of 7 days until either death or hospital discharge. We measured zinc concentration at baseline and during treatment and observed patients for any significant side effects. For eligible patients, we randomized and administered treatment to 33 adult participants to either HDIVZn (n = 15) or placebo (n = 18). We observed no serious adverse events throughout the study for a total of 94 HDIVZn administrations. However, three participants in the HDIVZn group reported infusion site irritation. Mean serum zinc on Day 1 in the placebo, and the HDIVZn group was 6.9 ± 1.1 and 7.7 ± 1.6 µmol/l, respectively, consistent with zinc deficiency. HDIVZn, but not placebo, increased serum zinc levels above the deficiency cutoff of 10.7 µmol/l (p < .001) on Day 6. Our study did not reach its target enrollment because stringent public health measures markedly reduced patient hospitalizations. Hospitalized COVID-19 patients demonstrated zinc deficiency. This can be corrected with HDIVZn. Such treatment appears safe, feasible, and only associated with minimal peripheral infusion site irritation. This pilot study justifies further investigation of this treatment in COVID-19 patients.read more
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Drug treatments for covid-19: living systematic review and network meta-analysis.
Reed A C Siemieniuk,Jessica J Bartoszko,Long Ge,Dena Zeraatkar,Ariel Izcovich,Elena Kum,Hector Pardo-Hernandez,Anila Qasim,Juan Pablo Diaz Martinez,Bram Rochwerg,Francois Lamontagne,Mi Ah Han,Qin Liu,Arnav Agarwal,Arnav Agarwal,Thomas Agoritsas,Derek K. Chu,Rachel Couban,Ellen Cusano,Andrea Darzi,Tahira Devji,Bo Fang,Carmen Fang,Signe Flottorp,Signe Flottorp,Farid Foroutan,Farid Foroutan,Maryam Ghadimi,Diane Heels-Ansdell,Kimia Honarmand,Liangying Hou,Xiaorong Hou,Quazi Ibrahim,Assem M. Khamis,Bonnie Lam,Mark Loeb,Maura Marcucci,Shelley McLeod,Sharhzad Motaghi,Srinivas Murthy,Reem A. Mustafa,Reem A. Mustafa,John Neary,Gabriel Rada,Irbaz Bin Riaz,Behnam Sadeghirad,Nigar Sekercioglu,Lulu Sheng,Ashwini Sreekanta,Charlotte Switzer,Britta Tendal,Lehana Thabane,George Tomlinson,Tari Turner,Per Olav Vandvik,Robin W.M. Vernooij,Andrés Viteri-García,Ying Wang,Liang Yao,Zhikang Ye,Gordon H Guyatt,Romina Brignardello-Petersen +61 more
TL;DR: Glucocorticoids probably reduce mortality and mechanical ventilation in patients with covid-19 compared with standard care and the effectiveness of most interventions is uncertain because most of the randomised controlled trials so far have been small and have important study limitations.
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Zinc and selenium supplementation in COVID-19 prevention and treatment: a systematic review of the experimental studies
TL;DR: A systematic review of published and unpublished clinical trials using zinc or selenium supplementation to treat or prevent COVID-19 in the Pubmed, Scopus and ClinicalTrials databases up to 10 January 2022 is presented in this paper .
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Clinical significance of micronutrient supplements in patients with coronavirus disease 2019: A comprehensive systematic review and meta-analysis
Azizullah Beran,Mohammed Mhanna,Omar Srour,Hazem Ayesh,Jamie M. Stewart,Majdal Hjouj,Waleed Khokher,Asmaa S Mhanna,Dana Ghazaleh,Yasmin Khader,Wasef Sayeh,Ragheb Assaly +11 more
TL;DR: The clinical significance of these individual micronutrients in patients with Coronavirus disease 2019 (COVID-19) remains unclear as discussed by the authors , and a comprehensive literature search using MEDLINE, Embase, and Cochrane databases through December 5th, 2021 was conducted to provide a quantitative assessment of the clinical significance.
Journal ArticleDOI
Twice-Daily Oral Zinc in the Treatment of Patients With Coronavirus Disease 2019: A Randomized Double-Blind Controlled Trial.
Saoussen Ben Abdallah,Yosra Mhalla,Imen Trabelsi,Adel Sekma,Rim Youssef,Khaoula Bel Haj Ali,Houda Ben Soltane,Hajer Yacoubi,Mohamed Amine Msolli,Nejla Stambouli,Kaouthar Beltaief,Mohamed Habib Grissa,Meriem Khrouf,Zied Mezgar,C. Loussaief,Wahid Bouida,R. Razgallah,Karima Hezbri,Asma Sriha Belguith,Naouel Belkacem,Zohra Dridi,Hamdi Boubaker,Riadh Boukef,Semir Nouira +23 more
TL;DR: In this article , a prospective, randomized, double-blind, placebo-controlled multicenter trial was conducted to examine zinc efficacy in adult patients with COVID-19 infection, where patients who were tested positive for CoV-19 without end-organ failure were randomized to either oral zinc (n = 231) or matching placebo(n = 239) for 15 days.
Journal ArticleDOI
Nutritional risk of vitamin D, vitamin C, zinc, and selenium deficiency on risk and clinical outcomes of COVID-19: A narrative review
TL;DR: A literature search was performed on PubMed and Google Scholar to obtain findings of cross-sectional and experimental studies in humans as mentioned in this paper , which resulted in a total of 1212 reports including all nutrients, but only 85 were included according to the eligibility criteria.
References
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Journal Article
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Kenneth H. Brown,Juan A Rivera,Zulfiqar A. Bhutta,Rosalind S Gibson,Janet C King,Bo Lönnerdal,Marie T. Ruel,Brittmarie Sandtröm,Emorn Wasantwisut,Christine Hotz +9 more
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TL;DR: It is demonstrated that the combination of Zn2+ and PT at low concentrations reduces the replication of SARS-coronavirus (SARS-CoV) and equine arteritis virus (EAV) in cell culture and efficiently inhibits the RNA-synthesizing activity of the RTCs of both viruses.
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TL;DR: Signs suggest that zinc status may possess protective effect as preventive and adjuvant therapy of COVID-19 through reducing inflammation, improvement of mucociliary clearance, prevention of ventilator-induced lung injury, modulation of antiviral and antibacterial immunity.
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