A potential therapeutic target in traditional Chinese medicine for ulcerative colitis: Macrophage polarization
Zhihua Yang,Shan-Shan Lin,Wan-Shu Feng,Yangxi Liu,Zhihui Song,Gui-Xia Pan,Yuhang Zhang,Xiangdong Dai,X. Ding,Lu Lu Chen,Yi Wang +10 more
Reads0
Chats0
TLDR
Evidence has shown that traditional Chinese medicine (TCM) has positive therapeutic effects on UC by restoring the balance of M1/M2 macrophage polarization, and the potential mechanism of TCM regulating macrophages polarization in the treatment of UC is summarized.Abstract:
Intestinal macrophages are the main participants of intestinal immune homeostasis and intestinal inflammation. Under different environmental stimuli, intestinal macrophages can be polarized into classical activated pro-inflammatory phenotype (M1) and alternative activated anti-inflammatory phenotype (M2). Its different polarization state is the “guide” to promoting the development and regression of inflammation. Under normal circumstances, intestinal macrophages can protect the intestine from inflammatory damage. However, under the influence of some genetic and environmental factors, the polarization imbalance of intestinal M1/M2 macrophages will lead to the imbalance in the regulation of intestinal inflammation and transform the physiological inflammatory response into pathological intestinal injury. In UC patients, the disorder of intestinal inflammation is closely related to the imbalance of intestinal M1/M2 macrophage polarization. Therefore, restoring the balance of M1/M2 macrophage polarization may be a potentially valuable therapeutic strategy for UC. Evidence has shown that traditional Chinese medicine (TCM) has positive therapeutic effects on UC by restoring the balance of M1/M2 macrophage polarization. This review summarizes the clinical evidence of TCM for UC, the vital role of macrophage polarization in the pathophysiology of UC, and the potential mechanism of TCM regulating macrophage polarization in the treatment of UC. We hope this review may provide some new enlightenment for the clinical treatment, fundamental research, and research and development of new Chinese medicine of UC.read more
Citations
More filters
Journal ArticleDOI
Berberine a traditional Chinese drug repurposing: Its actions in inflammation-associated ulcerative colitis and cancer therapy
TL;DR: Berberine (BBR) is an isoquinoline alkaloid extracted from Coptidis Rhizoma, which has a long history of treating dysentery in the clinic as mentioned in this paper .
Journal ArticleDOI
A potential therapeutic approach for ulcerative colitis: targeted regulation of macrophage polarization through phytochemicals
Kesheng Wang,Tangyou Mao,Xinyu Lu,Muyuan Wang,Yifei Yun,Zeyu Jia,Lei Shi,Junxiang Li,Rui Shi +8 more
TL;DR: In this paper , the influence of macrophage polarization on the development of colorectal ulcerative colitis (UC) was discussed and the significant potential of natural substances that can target the macocyte phenotype and elucidate the possible mechanism of action for its treatment.
Journal ArticleDOI
New insights into muscularis macrophages in the gut: from their origin to therapeutic targeting.
Journal ArticleDOI
Pro-inflammatory Polarization of Macrophages Causes Intestinal Inflammation in Low-Birth-Weight Piglets and Mice.
Xiangyu Zhang,Yujun Wu,Xiaoyi Liu,Xu Lin,Yisi Liu,Luyuan Kang,Hao Ye,Zhenyu Wang,Yingying Ma,Zhaolai Dai,Dongsheng Che,Yu Pi,Lianqiang Che,Junjun Wang,Dandan Han +14 more
TL;DR: In this paper , the role of macrophages in intestinal inflammation in low birth weight (LBW) pigs and mice was investigated by using immunofluorescence and flow cytometry.
Journal ArticleDOI
Targeting intestinal microecology: potential intervention strategies of traditional Chinese medicine for managing hypertension
Zhihua Yang,Shan-Shan Lin,Yangxi Liu,Zhi-Jian Song,Zhao Ge,Yujian Fan,Lu Lu Chen,Ying-fei Bi,Zhiqiang Zhao,Xianliang Wang,Yi Wang,Jingyuan Mao +11 more
TL;DR: Wang et al. as mentioned in this paper analyzed the relationship among TCM, intestinal microecology and hypertension, and presented the methods by which TCM regulates intestinal micro-ecology to prevent and treat hypertension.
References
More filters
Journal ArticleDOI
Monocyte and macrophage heterogeneity
Siamon Gordon,Philip R. Taylor +1 more
TL;DR: Recent studies have shown that monocyte heterogeneity is conserved in humans and mice, allowing dissection of its functional relevance: the different monocyte subsets seem to reflect developmental stages with distinct physiological roles, such as recruitment to inflammatory lesions or entry to normal tissues.
Journal ArticleDOI
Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines
Peter J. Murray,Judith E. Allen,Subhra K. Biswas,Edward A. Fisher,Derek W. Gilroy,Sergij Goerdt,Siamon Gordon,John A. Hamilton,Lionel B. Ivashkiv,Toby Lawrence,Massimo Locati,Alberto Mantovani,Fernando O. Martinez,Jean-Louis Mege,David M. Mosser,Gioacchino Natoli,Jeroen P. J. Saeij,Joachim L. Schultze,Kari Ann Shirey,Antonio Sica,Jill Suttles,Irina A. Udalova,Jo A. Van Ginderachter,Stefanie N. Vogel,Thomas A. Wynn +24 more
TL;DR: A set of standards encompassing three principles-the source of macrophages, definition of the activators, and a consensus collection of markers to describe macrophage activation are described with the goal of unifying experimental standards for diverse experimental scenarios.
Journal ArticleDOI
Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies
Siew C. Ng,Hai Yun Shi,Hai Yun Shi,Nima Hamidi,Fox E. Underwood,Whitney Tang,Eric I Benchimol,Eric I Benchimol,Remo Panaccione,Subrata Ghosh,Justin C.Y. Wu,Francis K.L. Chan,Joseph J.Y. Sung,Gilaad G. Kaplan +13 more
TL;DR: The changing incidence and prevalence of inflammatory bowel disease around the world has become a global disease with accelerating incidence in newly industrialised countries whose societies have become more westernised and burden remains high as prevalence surpasses 0·3%.
Journal ArticleDOI
Development of Monocytes, Macrophages, and Dendritic Cells
TL;DR: The current understanding of myeloid lineage development is reviewed and the developmental pathways and cues that drive differentiation are described, which are central to the development of immunologic memory and tolerance in mice.
Journal ArticleDOI
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.
Roel Nusse,Hans Clevers +1 more
TL;DR: The core Wnt/β-catenin signaling pathway is described, how it controls stem cells, and contributes to disease, and strategies for Wnt-based therapies are discussed.