α-Synuclein and dopamine at the crossroads of Parkinson's disease
TLDR
Recent findings from genome-wide association studies, which reveal the involvement of α-synuclein gene variants in sporadic PD, are brought together to provide a central link between the genetic findings and neurodegeneration observed in sporadicPD.About:
This article is published in Trends in Neurosciences.The article was published on 2010-12-01 and is currently open access. It has received 233 citations till now. The article focuses on the topics: Neurodegeneration & Parkinson's disease.read more
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Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences
TL;DR: The role of mitochondria in the etiopathogenesis of Parkinson's disease has been investigated in this paper, based on the observation that mitochondrial toxins can cause parkinsonism in humans and animal models.
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O1-7-4-1Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
Wataru Satake,Ikuko Mizuta,Michiaki Kubo,Takahisa Kawaguchi,Tatsuhiko Tsunoda,Takeo Yoshikawa,Saburo Sakoda,Mitsutoshi Yamamoto,Nobutaka Hattori,Miho Murata,Yusuke Nakamura,Tatsushi Toda +11 more
TL;DR: Clinical and genetic information of 5 Japanese patients with Bardet-Biedl syndrome is summarized and it is found that rare liver fibrosis was detected in two patients, while only two patients had renal dysfunction, thought to be a universal symptom.
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Neuropathology of sporadic Parkinson's disease: Evaluation and changes of concepts
TL;DR: Recent research has improved both the clinical and neuropathological diagnostic criteria of PD and provided insights into the development and staging of αSyn and Lewy pathologies and has been useful in understanding the pathogenesis of PD.
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Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade
Masha G. Savelieff,Geewoo Nam,Geewoo Nam,Juhye Kang,Juhye Kang,Hyuck Jin Lee,Misun Lee,Misun Lee,Mi Hee Lim +8 more
TL;DR: Possible therapeutic targets in Alzheimer's disease, Parkinson's Disease, and amyotrophic lateral sclerosis are outlined and molecules, previously designed or discovered as potential drug candidates for these disorders with emphasis on multifunctionality are discussed.
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Profiles of Extracellular miRNA in Cerebrospinal Fluid and Serum from Patients with Alzheimer's and Parkinson's Diseases Correlate with Disease Status and Features of Pathology
Kasandra Burgos,Ivana Malenica,Raghu Metpally,Amanda Courtright,Benjamin Rakela,Thomas G. Beach,Holly A. Shill,Charles H. Adler,Marwan N. Sabbagh,Stephen Villa,Waibhav Tembe,David Craig,Kendall Van Keuren-Jensen +12 more
TL;DR: Data indicate that extracellular miRNAs detectable in the cerebrospinal fluid and serum are reflective of cell-based changes in pathology and can be used to assess disease progression and therapeutic efficacy.
References
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Mutation in the α-synuclein gene identified in families with Parkinson's disease
Mihael H. Polymeropoulos,Christian Lavedan,Elisabeth Leroy,Susan E. Ide,Anindya Dehejia,Amalia Dutra,Brian L. Pike,Holly Root,Jeffrey Rubenstein,Rebecca Boyer,Edward S. Stenroos,Settara C. Chandrasekharappa,Aglaia Athanassiadou,Theodore Papapetropoulos,William G. Johnson,Alice Lazzarini,Roger C. Duvoisin,Giuseppe Di Iorio,Lawrence I. Golbe,Robert L. Nussbaum +19 more
TL;DR: A mutation was identified in the α-synuclein gene, which codes for a presynaptic protein thought to be involved in neuronal plasticity, in the Italian kindred and in three unrelated families of Greek origin with autosomal dominant inheritance for the PD phenotype.
Journal ArticleDOI
Alpha-synuclein in Lewy bodies.
Maria Grazia Spillantini,Marie L. Schmidt,Virginia M.-Y. Lee,John Q. Trojanowski,Ross Jakes,Michel Goedert +5 more
TL;DR: Strong staining of Lewy bodies from idiopathic Parkinson's disease with antibodies for α-synuclein, a presynaptic protein of unknown function which is mutated in some familial cases of the disease, indicates that the LewY bodies from these two diseases may have identical compositions.
Journal ArticleDOI
α-Synuclein Locus Triplication Causes Parkinson's Disease
Andrew B. Singleton,Matthew J. Farrer,Joshua C. Johnson,Amanda Singleton,Stephen Hague,Jennifer M. Kachergus,Mary M. Hulihan,Terhi Peuralinna,Amalia Dutra,Robert L. Nussbaum,Sarah Lincoln,Anthony Crawley,Melissa Hanson,Demetrius M. Maraganore,Charles H. Adler,Mark R. Cookson,Manfred D. Muenter,Melisa J. Baptista,David Miller,J. Blancato,John Hardy,Katrina Gwinn-Hardy +21 more
TL;DR: In this article, the α-synuclein was identified as the major component of Lewy bodies, the pathological hallmark of Parkinson's disease, and of glial cell cytoplasmic inclusions.
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Mutation in the α-synuclein gene identified in families with Parkinson's disease
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α-Synuclein Locus Triplication Causes Parkinson's Disease
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