Journal ArticleDOI
A two-pronged photodynamic nanodrug to prevent metastasis of basal-like breast cancer.
TLDR
A two-pronged concept combining photodynamic therapy (PDT) and epithelial-mesenchymal transition (EMT) blockade in a minimalist nanoplatform was proposed to combat basal-like breast cancer (BLBC) metastasis as discussed by the authors.About:Â
This article is published in Chemical Communications.The article was published on 2021-03-02. It has received 84 citations till now. The article focuses on the topics: Metastasis.read more
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PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application.
TL;DR: In this article, a review of the application of PLGA microspheres in drug delivery and the treatment of pulmonary and ocular-related diseases is presented, including the delivery of various anticancer drugs, protein or peptide drugs, bacterial or viral DNA.
Journal ArticleDOI
Recent advances in nanomedicines for photodynamic therapy (PDT)-driven cancer immunotherapy
Bin Ji,Minjie Wei,Bin Yan +2 more
TL;DR: The emerging nanomedicine-based strategies could subtly modulate the pharmacokinetics of therapeutic compounds and the TME to optimize both PDT and immunotherapy, resulting in an improved antitumor effect, and highlights the synergistic nanotherapeutics used to amplify immune responses combined with immunotherapy against tumors.
Journal ArticleDOI
Mitochondria-targeted ROS- and GSH-responsive diselenide-crosslinked polymer dots for programmable paclitaxel release
TL;DR: PTX was selectively released from PD-TPP in cancer cells, reducing cell viability and causing enhanced apoptosis of cancer cells compared to normal cells, and this approach could be a potential strategy to enhance therapeutic efficacy of cancer drugs and minimize the side effects on normal cells.
Journal ArticleDOI
Therapeutic potential of graphyne as a new drug-delivery system for daunorubicin to treat cancer: A DFT study
Iqra Munir,Mehvish Perveen,Sidra Nazir,Rasheed Ahmad Khera,Ali Raza Ayub,Khurshid Ayub,Javed Iqbal +6 more
TL;DR: In this article, the authors investigated the effectiveness of graphyne as a carrier for delivery of anticancer drug, daunorubicin, with the help of calculations of some physiochemical properties such as band-gap, dipole-moment, and chemical-reactivity-descriptors for graphyne.
Journal ArticleDOI
Nanoparticle-Mediated Targeted Drug Delivery to Remodel Tumor Microenvironment for Cancer Therapy.
Lu Tang,Yijun Mei,Yan Shen,Shun He,Qiaqia Xiao,Yue Yin,Yonggang Xu,Jie Shao,Wei Wang,Zihao Cai +9 more
TL;DR: In this paper, the authors present a review of the role of tumor microenvironment (TME) in tumorigenesis and discuss the application of nanotechnology in TME regulation.
References
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Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
Freddie Bray,Jacques Ferlay,Isabelle Soerjomataram,Rebecca L. Siegel,Lindsey A. Torre,Ahmedin Jemal +5 more
TL;DR: A status report on the global burden of cancer worldwide using the GLOBOCAN 2018 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer, with a focus on geographic variability across 20 world regions.
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Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
TL;DR: Owing to the importance of these tumour-associated phenotypes in metastasis and cancer-related mortality, targeting the products of such cellular plasticity is an attractive but challenging approach that is likely to lead to improved clinical management of cancer patients.
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Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
TL;DR: The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.
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Metastasis: recent discoveries and novel treatment strategies
Suzanne A. Eccles,Danny R. Welch +1 more
TL;DR: This work focuses on recent findings regarding intrinsic and extrinsic molecular mechanisms controlling metastasis that determine how, when, and where cancers metastasise, and their implications for patient management in the 21st century.
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Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas.
Bas Kreike,Marieke van Kouwenhove,Hugo M. Horlings,Britta Weigelt,Hans Peterse,Harry Bartelink,Marc J. van de Vijver +6 more
TL;DR: Triple-negative tumors are synonymous with basal-like tumors, and can be identified by immunohistochemistry, based on gene-expression profiling, which revealed five distinct subgroups of triple-negative breast cancers.