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An injectable hydrogel using an immunomodulating gelator for amplified tumor immunotherapy by blocking the arginase pathway.
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TLDR
In this article, an injectable hydrogel strategy via an L-norvaline-based immunomodulating gelator that could effectively block ARG1 pathway was presented.About:
This article is published in Acta Biomaterialia.The article was published on 2021-01-30. It has received 92 citations till now.read more
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PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application.
TL;DR: In this article, a review of the application of PLGA microspheres in drug delivery and the treatment of pulmonary and ocular-related diseases is presented, including the delivery of various anticancer drugs, protein or peptide drugs, bacterial or viral DNA.
Journal ArticleDOI
Self-Healing Injectable Hydrogels for Tissue Regeneration
TL;DR: A critical review of the current state of self-healing injectable hydrogels for tissue regeneration and a practical guide for their rheological analysis are provided to showcase their applicability for regeneration of various tissues and 3D printing of complex tissues and organoids.
Journal ArticleDOI
Mitochondria-targeted ROS- and GSH-responsive diselenide-crosslinked polymer dots for programmable paclitaxel release
TL;DR: PTX was selectively released from PD-TPP in cancer cells, reducing cell viability and causing enhanced apoptosis of cancer cells compared to normal cells, and this approach could be a potential strategy to enhance therapeutic efficacy of cancer drugs and minimize the side effects on normal cells.
Journal ArticleDOI
Therapeutic potential of graphyne as a new drug-delivery system for daunorubicin to treat cancer: A DFT study
Iqra Munir,Mehvish Perveen,Sidra Nazir,Rasheed Ahmad Khera,Ali Raza Ayub,Khurshid Ayub,Javed Iqbal +6 more
TL;DR: In this article, the authors investigated the effectiveness of graphyne as a carrier for delivery of anticancer drug, daunorubicin, with the help of calculations of some physiochemical properties such as band-gap, dipole-moment, and chemical-reactivity-descriptors for graphyne.
Journal ArticleDOI
Nanoparticle-Mediated Targeted Drug Delivery to Remodel Tumor Microenvironment for Cancer Therapy.
Lu Tang,Yijun Mei,Yan Shen,Shun He,Qiaqia Xiao,Yue Yin,Yonggang Xu,Jie Shao,Wei Wang,Zihao Cai +9 more
TL;DR: In this paper, the authors present a review of the role of tumor microenvironment (TME) in tumorigenesis and discuss the application of nanotechnology in TME regulation.
References
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Journal ArticleDOI
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy.
Lionel Apetoh,François Ghiringhelli,Antoine Tesniere,Antoine Tesniere,Antoine Tesniere,Michel Obeid,Michel Obeid,Michel Obeid,Carla Ortiz,Carla Ortiz,Carla Ortiz,Alfredo Criollo,Alfredo Criollo,Alfredo Criollo,Grégoire Mignot,Grégoire Mignot,Grégoire Mignot,M. Chiara Maiuri,Evelyn Ullrich,Evelyn Ullrich,Evelyn Ullrich,Patrick Saulnier,Huan Yang,Sebastian Amigorena,Bernard Ryffel,Franck J. Barrat,Paul Saftig,Francis Lévi,Francis Lévi,Rosette Lidereau,Catherine Noguès,Jean-Paul Mira,Agnès Chompret,Virginie Joulin,Françoise Clavel-Chapelon,Jean Bourhis,Fabrice Andre,Suzette Delaloge,T. Tursz,Guido Kroemer,Guido Kroemer,Guido Kroemer,Laurence Zitvogel +42 more
TL;DR: A previously unrecognized pathway for the activation of tumor antigen–specific T-cell immunity that involves secretion of the high-mobility-group box 1 (HMGB1) alarmin protein by dying tumor cells and the action of HMGB1 on Toll-like receptor 4 (TLR4) expressed by dendritic cells (DCs) is described.
Journal ArticleDOI
Designing hydrogels for controlled drug delivery.
Jianyu Li,David J. Mooney +1 more
TL;DR: This Review discusses how different mechanisms interact and can be integrated to exert fine control in time and space over the drug presentation, and collects experimental release data from the literature and presents quantitative comparisons between different systems to provide guidelines for the rational design of hydrogel delivery systems.
Journal ArticleDOI
Immunogenic cell death in cancer and infectious disease
TL;DR: Current knowledge on the mechanisms that underlie the activation of immune responses against dying cells and their pathophysiological relevance are reviewed.
Journal ArticleDOI
Immunogenic cell death and DAMPs in cancer therapy.
Dmitri V. Krysko,Abhishek D. Garg,Agnieszka Kaczmarek,Olga Krysko,Patrizia Agostinis,Peter Vandenabeele +5 more
TL;DR: The role of endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) in regulating the immunogenicity of dying cancer cells and the effect of therapy-resistant cancer microevolution on ICD are discussed.
Journal ArticleDOI
T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
TL;DR: T-cell priming by DCs occurs in three successive stages: transient serial encounters during the first activation phase are followed by a second phase of stable contacts culminating in cytokine production, which makes a transition into a third phase of high motility and rapid proliferation.