Ability of King's College Criteria and Model for End-Stage Liver Disease Scores to Predict Mortality of Patients With Acute Liver Failure: A Meta-analysis

TLDR: Based on a meta-analysis of studies, the KCC more accurately predicts hospital mortality among patients with AALF, whereas MELD scores more accurately predict mortalityamong patients with NAALF.

About: This article is published in Clinical Gastroenterology and Hepatology.The article was published on 2016-04-01 and is currently open access. It has received 91 citations till now. The article focuses on the topics: King's College Criteria & Model for End-Stage Liver Disease.

Figures

Table 2 Individual and pooled sensitivity, specificity, and diagnostic odds ratios (DOR) for King's College Criteria (KCC) and Model for End Stage Liver Disease (MELD).

Table 1 Characteristics of studies included in the meta-analysis (STARD - standards for reporting of diagnostic accuracy studies, AALF- acetaminophen related acute liver failure, NAALF (nonacetaminophen related acute liver failure, TB – tuberculosis, *midway year of study recruitment).

Table 3: Subgroup analysis of the performance of A) King’s College Criteria (KCC) and B) Model for End Stage Liver Disease (MELD) in predicting outcome in acute liver failure. (STARD – standards for the reporting of diagnostic accuracy studies, AALF acetaminophen related acute liver failure, NAALF non acetaminophen related acute liver failure, LR likelihood ratio, DOR diagnostic odds ratio, CI confidence interval.*midway year of study recruitment

Figure 1: Flow diagram of assessment of studies identified in the systematic review

Frequently asked questions

Q1. What have the authors contributed in "Meta-analysis of king's college criteria and model for end stage liver disease to predict outcome in acute liver failure" ?

The authors assessed the accuracy of King 's College Criteria ( KCC ) versus the Model-forEnd-Stage-Liver-Disease ( MELD ) in ALF through meta-analysis of studies which report the accuracy of both tests. 

Q2. What have the authors stated for future works in "Meta-analysis of king's college criteria and model for end stage liver disease to predict outcome in acute liver failure" ?

The authors hope these data help inform such decisions and future research. A worsening grade of HE can be detected at the bedside and incorporated into KCC without awaiting further biochemical analysis.