Acetylcholinesterase Inhibition by Flavonoids from Agrimonia pilosa
Mankil Jung,Moon Soo Park +1 more
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TLDR
It is reported for the first time that all four flavonol compounds showed significant inhibitory effects on AChE, particularly quercetin, which showed twice the activity of dehydroevodiamine (DHED).Abstract:
In a bioassay-guided search for acetylcholinesterase (AChE) inhibitors from 180 medicinal plants, an ethyl acetate extract of whole plants of Agrimonia pilosa ledeb yielded tiliroside (1), 3-methoxy quercetin (2), quercitrin (3) and quercetin (4). We report herein for the first time that all four flavonol compounds showed significant inhibitory effects on AChE, particularly quercetin (4), which showed twice the activity of dehydroevodiamine (DHED).read more
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References
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Journal ArticleDOI
A new and rapid colorimetric determination of acetylcholinesterase activity.
TL;DR: A photometric method for determining acetylcholinesterase activity of tissue extracts, homogenates, cell suspensions, etc., has been described and Kinetic constants determined by this system for erythrocyte eholinesterases are presented.
Journal ArticleDOI
Assessment of the anti-inflammatory activity and free radical scavenger activity of tiliroside.
Araceli Sala,M. Carmen Recio,Guillermo Raúl Schinella,Salvador Máñez,Rosa M. Giner,Miguel Cerdá-Nicolás,José-Luis Ríos +6 more
TL;DR: Three flavonoids, gnaphaliin, pinocembrin and tiliroside, isolated from Helichrysum italicum, were studied in vitro for their antioxidant and/or scavenger properties and in vivo in different models of inflammation.
Journal ArticleDOI
Antioxidant flavonoids from leaves of Polygonum hydropiper L.
Zhao Feng Peng,Dieter Strack,Alfred Baumert,R. Subramaniam,Ngoh Khang Goh,Tet Fatt Chia,Swee Ngin Tan,Lian Sai Chia +7 more
TL;DR: Evaluation of the antioxidative activity, conducted in vitro, by using electron spin resonance (ESR) and ultraviolet visible (UV-vis) spectrophotometric assays, showed that these isolated flavonoids possess strong antioxidative capabilities.
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Novel anticholinesterase and antiamnesic activities of dehydroevodiamine, a constituent of Evodia rutaecarpa
Cheol Hyoung Park,Sun-Jack Kim,Woong Hwan Choi,Yunhye Lee,Ju Sun Kim,Sam Sik Kang,Yoo-Hun Suh +6 more
TL;DR: The results indicate that DHED has novel anti-cholinesterase and antiamnesic activities and might have therapeutic potential in various disorders including Alzheimer's disease.
Journal ArticleDOI
Hepatoprotective principles from the flowers of Tilia argentea (Linden): Structure requirements of tiliroside and mechanisms of action
TL;DR: The methanolic extract from the flowers of Tilia argentea (linden) was found to show a hepatoprotective effect against D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced liver injury in mice, and its effect was suggested to depend on the inhibition of tumor necrosis factor-alpha (TNF-alpha) production, decreased sensitivity of hepatocytes to TNF- alpha, and on the protection of hepat