Journal ArticleDOI
Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA
Stefan Bauer,Veronika Groh,Jun Wu,Alexander Steinle,Joseph H. Phillips,Lewis L. Lanier,Thomas Spies +6 more
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TLDR
An activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses is defined.Abstract:
Stress-inducible MICA, a distant homolog of major histocompatibility complex (MHC) class I, functions as an antigen for gammadelta T cells and is frequently expressed in epithelial tumors. A receptor for MICA was detected on most gammadelta T cells, CD8+ alphabeta T cells, and natural killer (NK) cells and was identified as NKG2D. Effector cells from all these subsets could be stimulated by ligation of NKG2D. Engagement of NKG2D activated cytolytic responses of gammadelta T cells and NK cells against transfectants and epithelial tumor cells expressing MICA. These results define an activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses.read more
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Glucocorticoid dysregulation of natural killer cell function through epigenetic modification.
Karen Krukowski,Justin L. Eddy,Kelly Loster Kosik,Teresa Konley,Linda Witek Janusek,Herbert L. Mathews +5 more
TL;DR: Results demonstrate glucocorticoids to dysregulate NK cell function at least in part through an epigenetic mechanism, which reduces promoter accessibility through modification of histone acetylation status.
Journal ArticleDOI
NKG2D signaling on CD8⁺ T cells represses T-bet and rescues CD4-unhelped CD8⁺ T cell memory recall but not effector responses
Andrew Zloza,Andrew Zloza,Frederick J. Kohlhapp,Gretchen E. Lyons,Jason M. Schenkel,Tamson V. Moore,Tamson V. Moore,Andrew T. Lacek,Jeremy A. O'Sullivan,Jeremy A. O'Sullivan,Vineeth Varanasi,Jesse W. Williams,Michael C. Jagoda,Emily C. Bellavance,Amanda L. Marzo,Paul G. Thomas,Biljana Zafirova,Bojan Polić,Lena Al-Harthi,Anne I. Sperling,José A. Guevara-Patiño,José A. Guevara-Patiño +21 more
TL;DR: In this paper, augmented co-stimulation through NKG2D during priming paradoxically rescues memory, but not effector, CD8(+) T cell responses, characterized by reversal of elevated transcription factor T-box expressed in T cells (T-bet) expression and recovery of interleukin-2 and interferon-γ production and cytolytic responses.
Journal ArticleDOI
Prognostic value of MICA/B in cancers: a systematic review and meta-analysis
Yijing Zhao,Naifei Chen,Yu Yu,Lili Zhou,Chao Niu,Yudi Liu,Huimin Tian,Zheng Lv,Fujun Han,Jiuwei Cui +9 more
TL;DR: Serum soluble MICA/B represents a potential prognostic marker in various human cancers and was found associated with increased survival in patients with cancers of the digestive system.
Journal ArticleDOI
Serum levels of soluble major histocompatibility complex (MHC) class I-related chain A in patients with chronic liver diseases and changes during transcatheter arterial embolization for hepatocellular carcinoma.
Keisuke Kohga,Tetsuo Takehara,Tomohide Tatsumi,Kazuyoshi Ohkawa,Takuya Miyagi,Naoki Hiramatsu,Tatsuya Kanto,Tsutomu Kasugai,Kazuhiro Katayama,Michio Kato,Norio Hayashi +10 more
TL;DR: Although soluble MICA/B are produced from both HCC and premalignant cirrhotic livers, therapeutic intervention for HCC can reduce the levels of soluble Mica and thereby upregulate the expression of NKG2D, suggesting cancer therapy may have a beneficial effect on NKG 2D‐mediated antitumor immunity.
Journal ArticleDOI
Crystal Structure of a γδ T Cell Receptor Ligand T22: A Truncated MHC-Like Fold
TL;DR: T22 represents an unusual variant of the MHC-like fold and indicates that γδ and αβ TCRs interact differently with their respective MHC ligands.
References
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Journal ArticleDOI
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TL;DR: It is shown that murine lymphoma cells selected for loss of H–2 expression are less malignant after low-dose inoculation in syngeneic hosts than are wild-type cells, and that the rejection of such cells is non-adaptive.
Journal ArticleDOI
HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C
Veronique M. Braud,David S.J. Allan,Christopher A. O’Callaghan,Kalle Söderström,Annalisa D'Andrea,Graham S. Ogg,Sasha Lazetic,Neil Thomas Young,John I. Bell,Joseph H. Phillips,Lewis L. Lanier,Andrew J. McMichael +11 more
TL;DR: The identification of ligands for HLA-E is reported, which shows that a subset of HLA class I alleles has been shown to inhibit killing by CD94/NKG2A+ NK-cell clones, and only the HLA alleles that possess a leader peptide capable of upregulating Hla-E surface expression confer resistance toNK-cell-mediated lysis.
Journal ArticleDOI
Nk cell receptors
TL;DR: Three distinct receptor families, Ly49, CD94/NKG2, and KIR, are involved in NK cell recognition of polymorphic MHC class I molecules and a common pathway of inhibitory signaling is provided by ITIM sequences in the cytoplasmic domains of these otherwise structurally diverse receptors.
Journal ArticleDOI
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TL;DR: The analysis of the differences between two complex genomes holds promise for the discovery of infectious agents and probes useful for genetic studies, and may also be used for isolating probes linked to sites of genomic rearrangements.
Journal ArticleDOI
Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells
TL;DR: In this paper, the expression and recognition of a major histocompatibility complex (MHC) class I-related molecule, MICA, matches this localization, and the closely related MICB were recognized by intestinal epithelial T cells expressing diverse Vδ1 γδ TCRs.