Journal ArticleDOI
Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA
Stefan Bauer,Veronika Groh,Jun Wu,Alexander Steinle,Joseph H. Phillips,Lewis L. Lanier,Thomas Spies +6 more
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TLDR
An activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses is defined.Abstract:
Stress-inducible MICA, a distant homolog of major histocompatibility complex (MHC) class I, functions as an antigen for gammadelta T cells and is frequently expressed in epithelial tumors. A receptor for MICA was detected on most gammadelta T cells, CD8+ alphabeta T cells, and natural killer (NK) cells and was identified as NKG2D. Effector cells from all these subsets could be stimulated by ligation of NKG2D. Engagement of NKG2D activated cytolytic responses of gammadelta T cells and NK cells against transfectants and epithelial tumor cells expressing MICA. These results define an activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses.read more
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Inhibitory Receptor Signals Suppress Ligation-Induced Recruitment of NKG2D to GM1-Rich Membrane Domains at the Human NK Cell Immune Synapse
Johanna Endt,Fiona E. McCann,Catarina R. Almeida,Doris Urlaub,Rufina Leung,Daniela Pende,Daniel M. Davis,Carsten Watzl +7 more
TL;DR: It is proposed that one way in which inhibitory signaling can control NKG2D-mediated activation is by blocking its recruitment to GM1-rich membrane domains, which may provide the necessary platform from which stimulatory signals can proceed.
Journal ArticleDOI
Induction of MHC class I-related chain B (MICB) by 5-aza-2'-deoxycytidine.
Kai-Fu Tang,Cai-Xia He,Gui-Li Zeng,Jin-Feng Wu,Guan-Bin Song,Yi-Song Shi,Wei-guang Zhang,Ai-Long Huang,Alexander Steinle,Hong Ren +9 more
TL;DR: The results suggest that promoter DNA demethylation, in combination with DNA damage, contribute to the upregulation of MICB induced by 5-aza-dC.
Journal ArticleDOI
Letal, A tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells.
Jose R. Conejo-Garcia,Fabian Benencia,Maria C. Courreges,Eugene Khang,Lin Zhang,Alisha Mohamed-Hadley,Jeffrey M. Vinocur,Ronald J. Buckanovich,Craig B. Thompson,Bruce L. Levine,George Coukos +10 more
TL;DR: The characterization of Letal is reported, the first human transmembrane NKG2D ligand lacking an immunoglobulin-like a-3 ectodomain, suggesting that Letal delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes.
Journal ArticleDOI
Hepatitis B virus-induced hepatocellular carcinoma: functional roles of MICA variants.
Hoang Van Tong,Nguyen Linh Toan,Le Huu Song,C-Thomas Bock,Peter G. Kremsner,Thirumalaisamy P. Velavan +5 more
TL;DR: It is concluded that MICA polymorphisms play a crucial role in modulating innate immune responses, tumour surveillance and regulate disease susceptibility during HBV infection.
Journal ArticleDOI
Opposing effect of IFNγ and IFNα on expression of NKG2 receptors: Negative regulation of IFNγ on NK cells
Cai Zhang,Jian Zhang,Jian Zhang,Rui Sun,Rui Sun,Jinbo Feng,Haiming Wei,Zhigang Tian,Zhigang Tian,Zhigang Tian +9 more
TL;DR: It is shown for the first time that IFNγ negatively regulates NK cells through NKG2 receptors, and that the balance between stimulatory and inhibitory signals through theNKG2 family of receptors may be controlled by two opposing interferons.
References
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TL;DR: The identification of ligands for HLA-E is reported, which shows that a subset of HLA class I alleles has been shown to inhibit killing by CD94/NKG2A+ NK-cell clones, and only the HLA alleles that possess a leader peptide capable of upregulating Hla-E surface expression confer resistance toNK-cell-mediated lysis.
Journal ArticleDOI
Nk cell receptors
TL;DR: Three distinct receptor families, Ly49, CD94/NKG2, and KIR, are involved in NK cell recognition of polymorphic MHC class I molecules and a common pathway of inhibitory signaling is provided by ITIM sequences in the cytoplasmic domains of these otherwise structurally diverse receptors.
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Journal ArticleDOI
Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells
TL;DR: In this paper, the expression and recognition of a major histocompatibility complex (MHC) class I-related molecule, MICA, matches this localization, and the closely related MICB were recognized by intestinal epithelial T cells expressing diverse Vδ1 γδ TCRs.