Journal ArticleDOI
Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA
Stefan Bauer,Veronika Groh,Jun Wu,Alexander Steinle,Joseph H. Phillips,Lewis L. Lanier,Thomas Spies +6 more
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TLDR
An activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses is defined.Abstract:
Stress-inducible MICA, a distant homolog of major histocompatibility complex (MHC) class I, functions as an antigen for gammadelta T cells and is frequently expressed in epithelial tumors. A receptor for MICA was detected on most gammadelta T cells, CD8+ alphabeta T cells, and natural killer (NK) cells and was identified as NKG2D. Effector cells from all these subsets could be stimulated by ligation of NKG2D. Engagement of NKG2D activated cytolytic responses of gammadelta T cells and NK cells against transfectants and epithelial tumor cells expressing MICA. These results define an activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses.read more
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Stratification analysis of MICA triplet repeat polymorphisms and HLA antigens associated with ulcerative colitis in Japanese.
S.S. Seki,Kazuhito Sugimura,Masao Ota,Jun Matsuzawa,Yoshihiko Katsuyama,Kisei Ishizuka,T. Mochizuki,Kenji Suzuki,Osamu Yoneyama,Nobuhisa Mizuki,Terasu Honma,Hidetoshi Inoko,Hitoshi Asakura +12 more
TL;DR: Results imply that the significant increase in MICA TM-STR 6 in Japanese patients with UC is attributable to linkage disequilibrium with HLA-B52.
Journal ArticleDOI
Dynamic Natural Killer Cell and T Cell Responses to Influenza Infection.
Kayla Frank,Silke Paust +1 more
TL;DR: This review will analyze how NK cell and T cell effector functions during influenza infection affect the host response and correlate with morbidity and mortality outcomes.
Journal ArticleDOI
Contribution of MHC class I chain-related A (MICA) gene polymorphism to genetic susceptibility for systemic lupus erythematosus
Giovanni Gambelunghe,Roberto Gerli,E. Bartoloni Bocci,P. Del Sindaco,Mehran Ghaderi,Carani B. Sanjeevi,Onelia Bistoni,Vittorio Bini,Alberto Falorni +8 more
TL;DR: This study provides the first demonstration of the independent association of the MICA gene polymorphism with genetic risk of SLE, and revealed that the interaction of the three major markers was associated with increasing genetic risk.
Journal ArticleDOI
Opportunities and limitations of natural killer cells as adoptive therapy for malignant disease
TL;DR: Optimum NK cytotoxicity may require licensing or priming with tumor cells, and recent discoveries in the molecular and cellular biology of NK cells inform the design of new strategies to maximize the cytotoxic potential ofNK cells for adoptive transfer to treat human malignancies.
Journal ArticleDOI
Reversal of epigenetic silencing of MHC class I chain-related protein A and B improves immune recognition of Merkel cell carcinoma.
TL;DR: In this paper, the authors showed that the lack of MIC expression was due to epigenetic silencing via MIC promoter hypo-acetylation, which was re-induced by pharmacological inhibition of histone deacetylases (HDACs) both in vitro and in vivo.
References
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Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy
TL;DR: It is shown that murine lymphoma cells selected for loss of H–2 expression are less malignant after low-dose inoculation in syngeneic hosts than are wild-type cells, and that the rejection of such cells is non-adaptive.
Journal ArticleDOI
HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C
Veronique M. Braud,David S.J. Allan,Christopher A. O’Callaghan,Kalle Söderström,Annalisa D'Andrea,Graham S. Ogg,Sasha Lazetic,Neil Thomas Young,John I. Bell,Joseph H. Phillips,Lewis L. Lanier,Andrew J. McMichael +11 more
TL;DR: The identification of ligands for HLA-E is reported, which shows that a subset of HLA class I alleles has been shown to inhibit killing by CD94/NKG2A+ NK-cell clones, and only the HLA alleles that possess a leader peptide capable of upregulating Hla-E surface expression confer resistance toNK-cell-mediated lysis.
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Nk cell receptors
TL;DR: Three distinct receptor families, Ly49, CD94/NKG2, and KIR, are involved in NK cell recognition of polymorphic MHC class I molecules and a common pathway of inhibitory signaling is provided by ITIM sequences in the cytoplasmic domains of these otherwise structurally diverse receptors.
Journal ArticleDOI
Cloning the differences between two complex genomes.
TL;DR: The analysis of the differences between two complex genomes holds promise for the discovery of infectious agents and probes useful for genetic studies, and may also be used for isolating probes linked to sites of genomic rearrangements.
Journal ArticleDOI
Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells
TL;DR: In this paper, the expression and recognition of a major histocompatibility complex (MHC) class I-related molecule, MICA, matches this localization, and the closely related MICB were recognized by intestinal epithelial T cells expressing diverse Vδ1 γδ TCRs.