Journal ArticleDOI
Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA
Stefan Bauer,Veronika Groh,Jun Wu,Alexander Steinle,Joseph H. Phillips,Lewis L. Lanier,Thomas Spies +6 more
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TLDR
An activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses is defined.Abstract:
Stress-inducible MICA, a distant homolog of major histocompatibility complex (MHC) class I, functions as an antigen for gammadelta T cells and is frequently expressed in epithelial tumors. A receptor for MICA was detected on most gammadelta T cells, CD8+ alphabeta T cells, and natural killer (NK) cells and was identified as NKG2D. Effector cells from all these subsets could be stimulated by ligation of NKG2D. Engagement of NKG2D activated cytolytic responses of gammadelta T cells and NK cells against transfectants and epithelial tumor cells expressing MICA. These results define an activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses.read more
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A fresh look at tumor immunosurveillance and immunotherapy
TL;DR: Detailed descriptions of stress-induced ligands on tumor cells recognized by innate effector cells, new subsets of T cells that regulate tumor tolerance and the development of spontaneous tumors in mice that lack immune effector molecules, beckon a reflection on current perspectives on the interaction of transformed cells with the immune system and offer new hope of stimulating therapeutic immunity to cancer.
Journal ArticleDOI
Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion.
Yenan T. Bryceson,Michael E. March,Michael E. March,Hans-Gustaf Ljunggren,Hans-Gustaf Ljunggren,Eric O. Long,Eric O. Long +6 more
TL;DR: Resting NK cells were induced to secrete tumor necrosis factor alpha and interferon gamma and to kill target cells by engagement of specific, pair-wise combinations of receptors, revealing distinct and specific patterns of synergy among receptors on resting NK cells.
Journal ArticleDOI
Functionally Distinct Subsets of CD1d-restricted Natural Killer T Cells Revealed by CD1d Tetramer Staining
TL;DR: The results show that the various activities of CD1d-restricted T cells in tumor rejection, autoimmune disease, and microbial infections could result from activation of functionally distinct subsets, and that inflammatory and antigenic stimuli may influence different effector functions.
Journal ArticleDOI
Recognition of a virus-encoded ligand by a natural killer cell activation receptor.
Hamish R. C. Smith,Jonathan W. Heusel,Indira K. Mehta,Sung Jin Kim,Brigitte G. Dorner,Olga V. Naidenko,Koho Iizuka,Hiroshi Furukawa,Diana L. Beckman,Jeanette T. Pingel,Anthony A. Scalzo,Daved H. Fremont,Wayne M. Yokoyama +12 more
TL;DR: Exploiting a bioinformatics approach to the MCMV genome, at least 11 ORFs for molecules with previously unrecognized features of predicted MHC-like folds and limited MHC sequence homology are found and m157 triggers Ly49H-mediated cytotoxicity, and cytokine and chemokine production by freshly isolated NK cells.
Journal ArticleDOI
Gammadelta T cells: functional plasticity and heterogeneity.
Simon R. Carding,Paul J. Egan +1 more
TL;DR: It is argued that γδ T cells perform different functions according to their tissue distribution, antigen-receptor structure and local microenvironment, and how and at what stage of the immune response they become activated.
References
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Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy
TL;DR: It is shown that murine lymphoma cells selected for loss of H–2 expression are less malignant after low-dose inoculation in syngeneic hosts than are wild-type cells, and that the rejection of such cells is non-adaptive.
Journal ArticleDOI
HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C
Veronique M. Braud,David S.J. Allan,Christopher A. O’Callaghan,Kalle Söderström,Annalisa D'Andrea,Graham S. Ogg,Sasha Lazetic,Neil Thomas Young,John I. Bell,Joseph H. Phillips,Lewis L. Lanier,Andrew J. McMichael +11 more
TL;DR: The identification of ligands for HLA-E is reported, which shows that a subset of HLA class I alleles has been shown to inhibit killing by CD94/NKG2A+ NK-cell clones, and only the HLA alleles that possess a leader peptide capable of upregulating Hla-E surface expression confer resistance toNK-cell-mediated lysis.
Journal ArticleDOI
Nk cell receptors
TL;DR: Three distinct receptor families, Ly49, CD94/NKG2, and KIR, are involved in NK cell recognition of polymorphic MHC class I molecules and a common pathway of inhibitory signaling is provided by ITIM sequences in the cytoplasmic domains of these otherwise structurally diverse receptors.
Journal ArticleDOI
Cloning the differences between two complex genomes.
TL;DR: The analysis of the differences between two complex genomes holds promise for the discovery of infectious agents and probes useful for genetic studies, and may also be used for isolating probes linked to sites of genomic rearrangements.
Journal ArticleDOI
Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells
TL;DR: In this paper, the expression and recognition of a major histocompatibility complex (MHC) class I-related molecule, MICA, matches this localization, and the closely related MICB were recognized by intestinal epithelial T cells expressing diverse Vδ1 γδ TCRs.