Journal ArticleDOI
Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA
Stefan Bauer,Veronika Groh,Jun Wu,Alexander Steinle,Joseph H. Phillips,Lewis L. Lanier,Thomas Spies +6 more
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TLDR
An activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses is defined.Abstract:
Stress-inducible MICA, a distant homolog of major histocompatibility complex (MHC) class I, functions as an antigen for gammadelta T cells and is frequently expressed in epithelial tumors. A receptor for MICA was detected on most gammadelta T cells, CD8+ alphabeta T cells, and natural killer (NK) cells and was identified as NKG2D. Effector cells from all these subsets could be stimulated by ligation of NKG2D. Engagement of NKG2D activated cytolytic responses of gammadelta T cells and NK cells against transfectants and epithelial tumor cells expressing MICA. These results define an activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses.read more
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Function of the intestinal epithelium and its dysregulation in inflammatory bowel disease
Paul Henderson,Paul Henderson,Johan Van Limbergen,Jürgen Schwarze,David C. Wilson,David C. Wilson +5 more
TL;DR: This review focuses on recent developments in the structure of the epithelium, including a detailed account of the apical junctional complex in addition to the role of the enterocyte in antigen recognition, uptake, processing, and presentation.
Journal ArticleDOI
Overcoming Resistance to Natural Killer Cell Based Immunotherapies for Solid Tumors
TL;DR: The need to further optimize these strategies to improve the clinical outcome of NK cell based immunotherapy against solid tumors is highlighted.
Journal ArticleDOI
Enhanced Killing of Primary Ovarian Cancer by Retargeting Autologous Cytokine-Induced Killer Cells with Bispecific Antibodies: A Preclinical Study
John K. Chan,Chad A. Hamilton,M. K. Cheung,Mobin Karimi,Jeanette Baker,Jonathan M. Gall,Stephan Schulz,Steve H. Thorne,Nelson N.H. Teng,Christopher H. Contag,Lawrence G. Lum,Robert S. Negrin +11 more
TL;DR: Bispecific antibodies significantly enhanced the cytotoxicity of CIK cells in primary ovarian cancer cells and in the authors' in vivo mouse model, and the mechanism of cytolysis seems to be mediated in part by the NKG2D receptor.
Journal ArticleDOI
Synergistic induction of adaptive antitumor immunity by codelivery of antigen with α-galactosylceramide on exosomes.
Ulf Gehrmann,Stefanie Hiltbrunner,Anna-Maria Georgoudaki,Mikael C. I. Karlsson,Tanja I. Näslund,Susanne Gabrielsson +5 more
TL;DR: Findings show that exosomes loaded with protein antigen and αGC will activate adaptive immunity in the absence of triggering iNKT-cell anergy, supporting their application in the design of a broad variety of cancer immunotherapy trials.
Journal ArticleDOI
Interaction of Monocytes with NK Cells upon Toll-Like Receptor-Induced Expression of the NKG2D Ligand MICA
Mercedes Kloss,Patrice Decker,Katrin M. Baltz,Tina Baessler,Gundram Jung,Hans-Georg Rammensee,Alexander Steinle,Matthias Krusch,Helmut R. Salih +8 more
TL;DR: It is reported that human monocytes, upon TLR triggering, up-regulate MHC class I-Related Chain (MIC) A, but not other ligands for the activating immunoreceptor NKG2D like MICB or UL-16 binding proteins 1–3.
References
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TL;DR: The identification of ligands for HLA-E is reported, which shows that a subset of HLA class I alleles has been shown to inhibit killing by CD94/NKG2A+ NK-cell clones, and only the HLA alleles that possess a leader peptide capable of upregulating Hla-E surface expression confer resistance toNK-cell-mediated lysis.
Journal ArticleDOI
Nk cell receptors
TL;DR: Three distinct receptor families, Ly49, CD94/NKG2, and KIR, are involved in NK cell recognition of polymorphic MHC class I molecules and a common pathway of inhibitory signaling is provided by ITIM sequences in the cytoplasmic domains of these otherwise structurally diverse receptors.
Journal ArticleDOI
Cloning the differences between two complex genomes.
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Journal ArticleDOI
Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells
TL;DR: In this paper, the expression and recognition of a major histocompatibility complex (MHC) class I-related molecule, MICA, matches this localization, and the closely related MICB were recognized by intestinal epithelial T cells expressing diverse Vδ1 γδ TCRs.