Journal ArticleDOI
Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA
Stefan Bauer,Veronika Groh,Jun Wu,Alexander Steinle,Joseph H. Phillips,Lewis L. Lanier,Thomas Spies +6 more
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TLDR
An activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses is defined.Abstract:
Stress-inducible MICA, a distant homolog of major histocompatibility complex (MHC) class I, functions as an antigen for gammadelta T cells and is frequently expressed in epithelial tumors. A receptor for MICA was detected on most gammadelta T cells, CD8+ alphabeta T cells, and natural killer (NK) cells and was identified as NKG2D. Effector cells from all these subsets could be stimulated by ligation of NKG2D. Engagement of NKG2D activated cytolytic responses of gammadelta T cells and NK cells against transfectants and epithelial tumor cells expressing MICA. These results define an activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses.read more
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Activated and expanded natural killer cells target osteosarcoma tumor initiating cells in an NKG2D–NKG2DL dependent manner
Lucía Fernández,Jaime Valentín,Marta Zalacain,Wing Leung,Ana Patiño-García,Antonio Pérez-Martínez +5 more
TL;DR: The results show NKAE cells target OS cells including the TICs compartment, supporting the use of NK-cell based immunotherapies for OS.
Journal ArticleDOI
The role of Natural Killer cells in the pathogenesis of rheumatoid arthritis: Major contributors or essential homeostatic modulators?
David Ahern,Fionula M. Brennan +1 more
TL;DR: The current understanding of NK cell biology is outlined and how these cells may modulate disease pathogenesis in rheumatoid arthritis through interactions with other immune cells are outlined.
Journal ArticleDOI
CAR T Cell-Based Immunotherapy for the Treatment of Glioblastoma.
TL;DR: A review of CAR T cell-based approaches for the treatment of GBM can be found in this paper, where the authors summarize the mechanisms being explored in pre-clinical, as well as clinical studies to improve their anti-tumor activity.
Journal ArticleDOI
An Historical Overview: The Discovery of How NK Cells Can Kill Enemies, Recruit Defense Troops, and More
Massimo Vitale,Claudia Cantoni,Mariella Della Chiesa,Guido Ferlazzo,Simona Carlomagno,Daniela Pende,Michela Falco,Annamaria Pessino,Letizia Muccio,Andrea De Maria,Emanuela Marcenaro,Lorenzo Moretta,Simona Sivori +12 more
TL;DR: This review will specifically focus on the main activating NK receptors and on their crucial role in the ever-increasing number of functions assigned to NK cells and other innate lymphoid cells (ILCs).
Journal ArticleDOI
Molecular Determinants of Target Cell Recognition by Human γδ T Cells.
TL;DR: Accumulated knowledge on the diverse mechanisms of target cell recognition by γδ T cells are reviewed, focusing on human γ Δ T cells, to provide an integrated perspective of their therapeutic potential in cancer and infectious diseases.
References
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Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy
TL;DR: It is shown that murine lymphoma cells selected for loss of H–2 expression are less malignant after low-dose inoculation in syngeneic hosts than are wild-type cells, and that the rejection of such cells is non-adaptive.
Journal ArticleDOI
HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C
Veronique M. Braud,David S.J. Allan,Christopher A. O’Callaghan,Kalle Söderström,Annalisa D'Andrea,Graham S. Ogg,Sasha Lazetic,Neil Thomas Young,John I. Bell,Joseph H. Phillips,Lewis L. Lanier,Andrew J. McMichael +11 more
TL;DR: The identification of ligands for HLA-E is reported, which shows that a subset of HLA class I alleles has been shown to inhibit killing by CD94/NKG2A+ NK-cell clones, and only the HLA alleles that possess a leader peptide capable of upregulating Hla-E surface expression confer resistance toNK-cell-mediated lysis.
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Nk cell receptors
TL;DR: Three distinct receptor families, Ly49, CD94/NKG2, and KIR, are involved in NK cell recognition of polymorphic MHC class I molecules and a common pathway of inhibitory signaling is provided by ITIM sequences in the cytoplasmic domains of these otherwise structurally diverse receptors.
Journal ArticleDOI
Cloning the differences between two complex genomes.
TL;DR: The analysis of the differences between two complex genomes holds promise for the discovery of infectious agents and probes useful for genetic studies, and may also be used for isolating probes linked to sites of genomic rearrangements.
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Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells
TL;DR: In this paper, the expression and recognition of a major histocompatibility complex (MHC) class I-related molecule, MICA, matches this localization, and the closely related MICB were recognized by intestinal epithelial T cells expressing diverse Vδ1 γδ TCRs.