Journal ArticleDOI
Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA
Stefan Bauer,Veronika Groh,Jun Wu,Alexander Steinle,Joseph H. Phillips,Lewis L. Lanier,Thomas Spies +6 more
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TLDR
An activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses is defined.Abstract:
Stress-inducible MICA, a distant homolog of major histocompatibility complex (MHC) class I, functions as an antigen for gammadelta T cells and is frequently expressed in epithelial tumors. A receptor for MICA was detected on most gammadelta T cells, CD8+ alphabeta T cells, and natural killer (NK) cells and was identified as NKG2D. Effector cells from all these subsets could be stimulated by ligation of NKG2D. Engagement of NKG2D activated cytolytic responses of gammadelta T cells and NK cells against transfectants and epithelial tumor cells expressing MICA. These results define an activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses.read more
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Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptors.
Pearlie K. Epling-Burnette,Fanqi Bai,Jeffrey S. Painter,Dana E. Rollison,Helmut R. Salih,Matthias Krusch,JianXiang Zou,Edna Ku,Bin Zhong,David Boulware,Lynn C. Moscinski,Sheng Wei,Julie Y. Djeu,Alan F. List +13 more
TL;DR: Impairment of NK cytolytic function derives in part from reduced activating NK receptors such as NKG2D in association with disease progression, suggesting global defects in NK function.
Journal ArticleDOI
The Natural Cytotoxicity Receptors in Health and Disease.
TL;DR: It is highlighted how NCR biology is being harnessed for novel therapeutic interventions particularly for enhanced tumor surveillance and how this important class of receptors regulates the functions of tissue NK cells.
Journal ArticleDOI
Polyglandular autoimmune syndromes
TL;DR: Diagnosis of polyglandular autoimmune syndromes involves serological measurement of organ-specific autoantibodies and subsequent functional testing and management of patients with PAS including their family relatives is best performed in centres with special expertise in autoimmune endocrine disorders.
Journal ArticleDOI
Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation
Simona Sivori,Michela Falco,Emanuela Marcenaro,Silvia Parolini,Roberto Biassoni,Cristina Bottino,Lorenzo Moretta,Alessandro Moretta +7 more
TL;DR: The data show that a fail-safe mechanism preventing killing of normal autologous cells may be provided by the 2B4 surface molecule, which, at early stages of NK cell differentiation, functions as an inhibitory rather than as an activating receptor.
Journal ArticleDOI
Immunogenic cell death modalities and their impact on cancer treatment.
Oliver Kepp,Antoine Tesniere,Antoine Tesniere,Antoine Tesniere,Frédéric Schlemmer,Frédéric Schlemmer,Frédéric Schlemmer,Mickaël Michaud,Mickaël Michaud,Mickaël Michaud,Laura Senovilla,Laura Senovilla,Laura Senovilla,Laurence Zitvogel,Guido Kroemer,Guido Kroemer,Guido Kroemer +16 more
TL;DR: It is surmised that the response to cellular stress like chemotherapy or ionizing irradiation, dictates the immunological response to dying cells and that this immune response in turn determines the clinical outcome of anticancer therapies.
References
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Journal ArticleDOI
Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy
TL;DR: It is shown that murine lymphoma cells selected for loss of H–2 expression are less malignant after low-dose inoculation in syngeneic hosts than are wild-type cells, and that the rejection of such cells is non-adaptive.
Journal ArticleDOI
HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C
Veronique M. Braud,David S.J. Allan,Christopher A. O’Callaghan,Kalle Söderström,Annalisa D'Andrea,Graham S. Ogg,Sasha Lazetic,Neil Thomas Young,John I. Bell,Joseph H. Phillips,Lewis L. Lanier,Andrew J. McMichael +11 more
TL;DR: The identification of ligands for HLA-E is reported, which shows that a subset of HLA class I alleles has been shown to inhibit killing by CD94/NKG2A+ NK-cell clones, and only the HLA alleles that possess a leader peptide capable of upregulating Hla-E surface expression confer resistance toNK-cell-mediated lysis.
Journal ArticleDOI
Nk cell receptors
TL;DR: Three distinct receptor families, Ly49, CD94/NKG2, and KIR, are involved in NK cell recognition of polymorphic MHC class I molecules and a common pathway of inhibitory signaling is provided by ITIM sequences in the cytoplasmic domains of these otherwise structurally diverse receptors.
Journal ArticleDOI
Cloning the differences between two complex genomes.
TL;DR: The analysis of the differences between two complex genomes holds promise for the discovery of infectious agents and probes useful for genetic studies, and may also be used for isolating probes linked to sites of genomic rearrangements.
Journal ArticleDOI
Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells
TL;DR: In this paper, the expression and recognition of a major histocompatibility complex (MHC) class I-related molecule, MICA, matches this localization, and the closely related MICB were recognized by intestinal epithelial T cells expressing diverse Vδ1 γδ TCRs.