Journal ArticleDOI
AD dementia risk in late MCI, in early MCI, and in subjective memory impairment
Frank Jessen,Frank Jessen,Steffen Wolfsgruber,Steffen Wolfsgruber,Birgitt Wiese,Horst Bickel,Edelgard Mösch,Hanna Kaduszkiewicz,Michael Pentzek,Steffi G. Riedel-Heller,Tobias Luck,Angela Fuchs,Siegfried Weyerer,Jochen Werle,Hendrik van den Bussche,Martin Scherer,Wolfgang Maier,Wolfgang Maier,Michael Wagner,Michael Wagner +19 more
TLDR
To compare the risk of developing Alzheimer's disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective memory impairment (SMI) with normal test performance, three different approaches are considered.Abstract:
Objective To compare the risk of developing Alzheimer's disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective memory impairment (SMI) with normal test performance. Methods The baseline sample (n = 2892) of the prospective cohort study in nondemented individuals (German Study on Aging, Cognition and Dementia in Primary Care Patients) was divided into LMCI, EMCI, SMI, and control subjects by delayed recall performance. These groups were subdivided by the presence of self-reported concerns associated with experienced memory impairment. AD dementia risk was assessed over 6 years. Results Across all groups, risk of AD dementia was greatest in LMCI. In those with self-reported concerns regarding their memory impairment, SMI and EMCI were associated with a similarly increased risk of AD dementia. In those subgroups without concerns, SMI was not associated with increased risk of AD dementia, but EMCI remained an at-risk condition. Conclusions SMI and EMCI with self-reported concerns were associated with the same risk of AD dementia, suggesting that pre-LMCI risk conditions should be extended to SMI with concerns.read more
Citations
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2022 Alzheimer's disease facts and figures
TL;DR: The public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality and morbidity, use and costs of care, and the overall impact on family caregivers, the dementia workforce and society are described are described.
Journal ArticleDOI
Risk of dementia and mild cognitive impairment in older people with subjective memory complaints: meta-analysis
TL;DR: To investigate whether people with subjective memory complaints but no objective deficits are at increased risk of developing mild cognitive impairment (MCI) and dementia, and if so, how likely they are to develop dementia.
Journal ArticleDOI
Subjective Cognitive Decline in Preclinical Alzheimer's Disease
TL;DR: This paper reviewed essential features of subjective cognitive decline associated with preclinical AD and current measurement approaches, highlighting challenges in harmonizing study findings across settings, and examined the role of self-and informant-reports in SCD and various psychological, medical, and demographic factors that influence the self-report of cognition.
Journal ArticleDOI
Implementation of subjective cognitive decline criteria in research studies.
José Luis Molinuevo,Laura A. Rabin,Laura A. Rabin,Rebecca E. Amariglio,Rachel F. Buckley,Rachel F. Buckley,Rachel F. Buckley,Bruno Dubois,Kathryn A. Ellis,Michael Ewers,Harald Hampel,Harald Hampel,Stefan Klöppel,Lorena Rami,Barry Reisberg,Andrew J. Saykin,Sietske A.M. Sikkes,Colette M. Smart,Beth E. Snitz,Reisa A. Sperling,Wiesje M. van der Flier,Michael Wagner,Frank Jessen +22 more
TL;DR: In this article, the Subjective Cognitive Decline Initiative (SCD-I) published research criteria in the context of preclinical AD, with the aim of harmonization of SCD measurement across studies to enhance comparability and generalizability across studies.
Journal ArticleDOI
Subjective Cognitive Decline in Older Adults: An Overview of Self-Report Measures Used Across 19 International Research Studies
Laura A. Rabin,Laura A. Rabin,Laura A. Rabin,Colette M. Smart,Paul K. Crane,Rebecca E. Amariglio,Lorin M. Berman,Mercè Boada,Rachel F. Buckley,Gaël Chételat,Gaël Chételat,Gaël Chételat,Bruno Dubois,Kathryn A. Ellis,Katherine A. Gifford,Angela L. Jefferson,Frank Jessen,Frank Jessen,Mindy J. Katz,Richard B. Lipton,Tobias Luck,Paul Maruff,Michelle M. Mielke,José Luis Molinuevo,Farnia Naeem,Audrey Perrotin,Ronald C. Petersen,Lorena Rami,Barry Reisberg,Dorene M. Rentz,Steffi G. Riedel-Heller,Shannon L. Risacher,Octavio Rodriguez,Perminder S. Sachdev,Andrew J. Saykin,Melissa J. Slavin,Beth E. Snitz,Reisa A. Sperling,Caroline Tandetnik,Wiesje M. van der Flier,Michael Wagner,Michael Wagner,Steffen Wolfsgruber,Steffen Wolfsgruber,Sietske A.M. Sikkes +44 more
TL;DR: The Subjective Cognitive Decline Initiative (SCD-I) Working Group is an international consortium established to develop a conceptual framework and research criteria for SCD (Jessen et al. as mentioned in this paper ).
References
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