Open AccessJournal Article
Adaptive Immune Features of Natural Killer Cells
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In this paper, the authors used a mouse model of cytomegalovirus infection to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100fold in the spleen and 1,000-fold in liver after infection.Abstract:
In an adaptive immune response, naive T cells proliferate during infection and generate long-lived memory cells that undergo secondary expansion after a repeat encounter with the same pathogen. Although natural killer (NK) cells have traditionally been classified as cells of the innate immune system, they share many similarities with cytotoxic T lymphocytes. We use a mouse model of cytomegalovirus infection to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100-fold in the spleen and 1,000-fold in the liver after infection. After a contraction phase, Ly49H-positive NK cells reside in lymphoid and non-lymphoid organs for several months. These self-renewing 'memory' NK cells rapidly degranulate and produce cytokines on reactivation. Adoptive transfer of these NK cells into naive animals followed by viral challenge results in a robust secondary expansion and protective immunity. These findings reveal properties of NK cells that were previously attributed only to cells of the adaptive immune system.read more
Citations
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References
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Book ChapterDOI
Reptilia: Cellular Immunity in Reptiles: Perspective on Elements of Evolution
TL;DR: The study of cellular immunity in nonavian reptiles will fill an important gap in reconstructing the evolutionary history of amniote vertebrates, which to date has been poorly represented.
Dissertation
Regulation of Anti-viral Immunity by Dendritic Cells and Natural Killer Cells
TL;DR: It is shown that LPS-activated bone marrow-derived DCs express both 4-1BB and4-1BBL, and that these molecules constitutively interact on DCs, which means that survival, upregulation of key costimulatory molecules, cytokine/chemokine production, antigen presentation, and the ability of DCs to generate primary influenza-specific CD8 T cell responses were normal in the absence of 4- 1BB and/or 4-2BBL
Journal ArticleDOI
Correlation between circulating tumor cells EGFR expression and T cell subsets in advanced non-small cell lung cancer patients after tyrosine kinase inhibitor treatment.
TL;DR: CD4+/ CD8+ ratios and NK cells may be useful prognostic indicators for advanced NSCLC patients who receive TKIs treatment.
Journal ArticleDOI
Mouse Cytomegalovirus M34 Encodes a Non-essential, Nuclear, Early-Late Expressed Protein Required for Efficient Viral Replication.
TL;DR: It is revealed that MCMV remains replication competent despite the absence of M34, enabling functional studies in the infection context and revealing previous unsuccessful reconstitution attempts conducted by others.
Roles for the aryl hydrocarbon receptor in the immune response to Toxoplasma gondii
TL;DR: The work presented in this thesis examines the effects of AHR signaling during infection with the protozoan parasite Toxoplasma gondii, a medically significant pathogen that naturally infects mice and demonstrates context-dependent roles for the AHR during oral and chronic toxoplasmosis.