Open AccessJournal Article
Adaptive Immune Features of Natural Killer Cells
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In this paper, the authors used a mouse model of cytomegalovirus infection to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100fold in the spleen and 1,000-fold in liver after infection.Abstract:
In an adaptive immune response, naive T cells proliferate during infection and generate long-lived memory cells that undergo secondary expansion after a repeat encounter with the same pathogen. Although natural killer (NK) cells have traditionally been classified as cells of the innate immune system, they share many similarities with cytotoxic T lymphocytes. We use a mouse model of cytomegalovirus infection to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100-fold in the spleen and 1,000-fold in the liver after infection. After a contraction phase, Ly49H-positive NK cells reside in lymphoid and non-lymphoid organs for several months. These self-renewing 'memory' NK cells rapidly degranulate and produce cytokines on reactivation. Adoptive transfer of these NK cells into naive animals followed by viral challenge results in a robust secondary expansion and protective immunity. These findings reveal properties of NK cells that were previously attributed only to cells of the adaptive immune system.read more
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References
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Journal ArticleDOI
The anti-tumor role of NK cells in vivo pre-activated and re-stimulated by interleukins in acute lymphoblastic leukemia
TL;DR: It is argued strongly that in vivo IL pre-activation and re-stimulation is capable to induce memory-like NK cells as observed previously in vitro, which are effective against acute lymphoblastic leukemia, likely via NKG2D-dependent IFNγ production, in intact animals.
Journal ArticleDOI
Regulatory B Cell-Dependent Islet Transplant Tolerance Is Also Natural Killer Cell Dependent.
Christian Schuetz,Kang Mi Lee,Ryan Scott,Lisa Kojima,Laura Washburn,Liye Liu,Wei‐Hui Liu,Haley Tector,Ji Lei,Heidi Yeh,James Kim,James F. Markmann +11 more
TL;DR: Results show that regulatory function of B cells is dependent on NK cells in this model of transplantation tolerance, indicating that NK, but not NKT, cells are essential in B cell–dependent tolerance.
Book ChapterDOI
Metabolism in Immune Cell Differentiation and Function.
TL;DR: This chapter summarizes how metabolic programs are tuned and what the physiological consequences of metabolic reprogramming are as they relate to immune cell homeostasis, differentiation, and function.
Journal ArticleDOI
Tissue‐resident and memory properties of human T‐cell and NK‐cell subsets
TL;DR: This review will discuss the striking shared features of immunological memory and tissue residency recently discovered between T cells, a component of the adaptive immune system, and natural killer cells, members generally assigned to the innate compartment.
Journal ArticleDOI
Co-infection of Cytomegalovirus and Epstein-Barr Virus Diminishes the Frequency of CD56dimNKG2A+KIR- NK Cells and Contributes to Suboptimal Control of EBV in Immunosuppressed Children With Post-transplant Lymphoproliferative Disorder.
Janice K. P. Lam,Tarik Azzi,Kwai Fung Hui,Aikha M. G. Wong,Donal McHugh,Nicole Caduff,Koon-Ho Chan,Christian Münz,Alan K. S. Chiang +8 more
TL;DR: It is indicated that co-infection of CMV and EBV diminishes the frequency of CD56dimNKG2A+KIR− NK cells and contributes to suboptimal control of EBV in immunosuppressed children with PTLD.