Open AccessJournal Article
Adaptive Immune Features of Natural Killer Cells
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In this paper, the authors used a mouse model of cytomegalovirus infection to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100fold in the spleen and 1,000-fold in liver after infection.Abstract:
In an adaptive immune response, naive T cells proliferate during infection and generate long-lived memory cells that undergo secondary expansion after a repeat encounter with the same pathogen. Although natural killer (NK) cells have traditionally been classified as cells of the innate immune system, they share many similarities with cytotoxic T lymphocytes. We use a mouse model of cytomegalovirus infection to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100-fold in the spleen and 1,000-fold in the liver after infection. After a contraction phase, Ly49H-positive NK cells reside in lymphoid and non-lymphoid organs for several months. These self-renewing 'memory' NK cells rapidly degranulate and produce cytokines on reactivation. Adoptive transfer of these NK cells into naive animals followed by viral challenge results in a robust secondary expansion and protective immunity. These findings reveal properties of NK cells that were previously attributed only to cells of the adaptive immune system.read more
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References
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Journal ArticleDOI
Distinct Surface Expression of Activating Receptor Ly49H Drives Differential Expansion of NK Cell Clones upon Murine Cytomegalovirus Infection
Simon Grassmann,Ludwig O. Pachmayr,Justin Leube,Lorenz Mihatsch,Immanuel Andrae,Sophie Flommersfeld,Jennifer D. Oduro,Luka Cicin-Sain,Matthias Schiemann,Michael Flossdorf,Veit R. Buchholz +10 more
TL;DR: In this paper, the authors used retrogenic color-barcoding and single-cell adoptive transfers to track clonal immune responses to murine cytomegalovirus (MCMV) infection, derived from individual NK cells expressing activating receptor Ly49H.
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Dual Role of Natural Killer Cells on Graft Rejection and Control of Cytomegalovirus Infection in Renal Transplantation.
Miguel López-Botet,Carlos Vilches,Dolores Redondo-Pachón,Aura Muntasell,Aldi Pupuleku,José Yélamos,Julio Pascual,Marta Crespo +7 more
TL;DR: Evidence supporting that adaptive NKG2C+ NK cells may contribute to control the viral infection in kidney transplant recipients has been recently obtained, and the dual role of NK cells in the interrelation of HCMV infection with rejection deserves attention.
Journal ArticleDOI
Memory-like natural killer cells for cancer immunotherapy.
TL;DR: Current understanding of the heterogeneity of memory and memory-like NK cell responses, with distinct formation, molecular biology, and memory type functions, is reviewed.
Journal ArticleDOI
Latent cytomegalovirus infection enhances anti-tumour cytotoxicity through accumulation of NKG2C+ NK cells in healthy humans.
Austin B. Bigley,Katy Rezvani,Nina Shah,Takuya Sekine,N. Balneger,Mira Pistillo,Nadia H. Agha,Hawley E. Kunz,Daniel P. O'Connor,Catherine M. Bollard,Richard J. Simpson +10 more
TL;DR: It is concluded that latent CMV infection enhances NK cell cytotoxicity through accumulation of NKG2C+ NK cells, which may be beneficial in preventing the initiation and progression of haematological malignancies characterized by high HLA‐E expression.
Journal ArticleDOI
Enlarged Memory T-Cell Pool and Enhanced Th1-Type Responses in Chronic Myeloid Leukemia Patients Who Have Successfully Discontinued IFN-α Monotherapy
Mette Ilander,Anna Kreutzman,Peter Rohon,Teresa Melo,Edgar Faber,Kimmo Porkka,Jukka Vakkila,Satu Mustjoki +7 more
TL;DR: In addition to elevated NK-cell count, IFN-OFF patients have increased amount of memory T-cells, which are able to induce strong cytokine response upon stimulation, which may contribute to the maintenance of prolonged remission after successful interferon-α discontinuation.