Open AccessJournal Article
Adaptive Immune Features of Natural Killer Cells
Reads0
Chats0
TLDR
In this paper, the authors used a mouse model of cytomegalovirus infection to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100fold in the spleen and 1,000-fold in liver after infection.Abstract:
In an adaptive immune response, naive T cells proliferate during infection and generate long-lived memory cells that undergo secondary expansion after a repeat encounter with the same pathogen. Although natural killer (NK) cells have traditionally been classified as cells of the innate immune system, they share many similarities with cytotoxic T lymphocytes. We use a mouse model of cytomegalovirus infection to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100-fold in the spleen and 1,000-fold in the liver after infection. After a contraction phase, Ly49H-positive NK cells reside in lymphoid and non-lymphoid organs for several months. These self-renewing 'memory' NK cells rapidly degranulate and produce cytokines on reactivation. Adoptive transfer of these NK cells into naive animals followed by viral challenge results in a robust secondary expansion and protective immunity. These findings reveal properties of NK cells that were previously attributed only to cells of the adaptive immune system.read more
Citations
More filters
Journal ArticleDOI
Natural killer cells in antitumour adoptive cell immunotherapy
TL;DR: In this article , the authors describe various approaches to augment NK cell cytotoxicity and longevity, evaluate challenges and opportunities, and reflect on how lessons learned from the clinic will guide the design of next-generation NK cell products that will address the unique complexities of each cancer.
Journal ArticleDOI
Roles of natural killer cells in immunity to cancer, and applications to immunotherapy
TL;DR: The key features that underlie why NK cells are emerging as important new additions to the cancer therapeutic arsenal are considered.
Journal ArticleDOI
Trained ILC3 responses promote intestinal defense
Nicolas Serafini,Angélique Jarade,Laura Surace,Pedro de Araújo Gonçalves,Odile Sismeiro,Hugo Varet,Rachel Legendre,Jean-Yves Coppée,Olivier Disson,Scott K. Durum,Gad Frankel,James P. Di Santo +11 more
TL;DR: Intestinal group 3 innate lymphoid cells have memory-like properties after bacterial infection that contribute to long-term mucosal defense, and these “trained” ILC3s (Tr-ILC3s) showed superior activation and controlled infection better than “naïve’ I LC3s after pathogen rechallenge.
Journal ArticleDOI
Tumor-Infiltrating Lymphocytes in Colorectal Cancer: The Fundamental Indication and Application on Immunotherapy
TL;DR: P phenotypic diversities of TILs and their connections with prognosis in CRC are summarized and insights into the subsets-specific nature of Tils with different MSI status are provided.
Journal ArticleDOI
Inflammatory memory and tissue adaptation in sickness and in health
Shruti Naik,Elaine Fuchs +1 more
TL;DR: A review on inflammatory memory in non-immune cells of different epithelia and neurons, and the potential mechanisms controlling these epigenetic memories and their implications in human health and disease is presented in this article .
References
More filters
Journal ArticleDOI
Natural killer cells remember: an evolutionary bridge between innate and adaptive immunity?
Joseph C. Sun,Lewis L. Lanier +1 more
TL;DR: New findings showing how NK cells possess nearly all of the features of adaptive immunity including memory are proposed, proposing the placement of NK cells as an “evolutionary bridge” between innate and adaptive immunity.
Journal ArticleDOI
Current progress in development of hepatitis C virus vaccines
TL;DR: Advances in the understanding of virus-host interactions and protective immunity in hepatitis C virus infection provide an important roadmap to develop potent and broadly directed vaccine candidates targeting both humoral and cellular immune responses.
Journal ArticleDOI
Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer
Kathrin Buffen,Marije Oosting,Jessica Quintin,Aylwin Ng,Johanneke Kleinnijenhuis,Vinod Kumar,Esther van de Vosse,Cisca Wijmenga,Reinout van Crevel,Egbert Oosterwijk,Anne J. Grotenhuis,Sita H. Vermeulen,Lambertus A. Kiemeney,Frank L. van de Veerdonk,Georgios Chamilos,Ramnik J. Xavier,Jos W. M. van der Meer,Mihai G. Netea,Leo A. B. Joosten +18 more
TL;DR: It is demonstrated that autophagy contributes to trained immunity induced by BCG and that rs3759601 in ATG2B correlates with progression and recurrence of bladder cancer after BCG intravesical instillation therapy.
Journal ArticleDOI
Recruitment and Activation of Natural Killer (Nk) Cells in Vivo Determined by the Target Cell Phenotype: An Adaptive Component of Nk Cell–Mediated Responses
TL;DR: It is shown here that infiltration of activated NK cells into the peritoneal cavity in response to tumor cells is controlled by the tumor major histocompatibility complex (MHC) class I phenotype.
Journal ArticleDOI
Clinical utility of natural killer cells in cancer therapy and transplantation
TL;DR: Future strategies include exploiting favorable donor immunogenetics or ex vivo expansion of NK cells from blood, progenitors, or pluripotent cells, and monoclonal antibodies and bispecific killer engagers (BiKEs) may enhance specificity by targeting CD16 on NK cells to tumor antigens.