Open AccessJournal Article
Adaptive Immune Features of Natural Killer Cells
Reads0
Chats0
TLDR
In this paper, the authors used a mouse model of cytomegalovirus infection to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100fold in the spleen and 1,000-fold in liver after infection.Abstract:
In an adaptive immune response, naive T cells proliferate during infection and generate long-lived memory cells that undergo secondary expansion after a repeat encounter with the same pathogen. Although natural killer (NK) cells have traditionally been classified as cells of the innate immune system, they share many similarities with cytotoxic T lymphocytes. We use a mouse model of cytomegalovirus infection to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100-fold in the spleen and 1,000-fold in the liver after infection. After a contraction phase, Ly49H-positive NK cells reside in lymphoid and non-lymphoid organs for several months. These self-renewing 'memory' NK cells rapidly degranulate and produce cytokines on reactivation. Adoptive transfer of these NK cells into naive animals followed by viral challenge results in a robust secondary expansion and protective immunity. These findings reveal properties of NK cells that were previously attributed only to cells of the adaptive immune system.read more
Citations
More filters
Journal ArticleDOI
Natural killer cells in antitumour adoptive cell immunotherapy
TL;DR: In this article , the authors describe various approaches to augment NK cell cytotoxicity and longevity, evaluate challenges and opportunities, and reflect on how lessons learned from the clinic will guide the design of next-generation NK cell products that will address the unique complexities of each cancer.
Journal ArticleDOI
Roles of natural killer cells in immunity to cancer, and applications to immunotherapy
TL;DR: The key features that underlie why NK cells are emerging as important new additions to the cancer therapeutic arsenal are considered.
Journal ArticleDOI
Trained ILC3 responses promote intestinal defense
Nicolas Serafini,Angélique Jarade,Laura Surace,Pedro de Araújo Gonçalves,Odile Sismeiro,Hugo Varet,Rachel Legendre,Jean-Yves Coppée,Olivier Disson,Scott K. Durum,Gad Frankel,James P. Di Santo +11 more
TL;DR: Intestinal group 3 innate lymphoid cells have memory-like properties after bacterial infection that contribute to long-term mucosal defense, and these “trained” ILC3s (Tr-ILC3s) showed superior activation and controlled infection better than “naïve’ I LC3s after pathogen rechallenge.
Journal ArticleDOI
Tumor-Infiltrating Lymphocytes in Colorectal Cancer: The Fundamental Indication and Application on Immunotherapy
TL;DR: P phenotypic diversities of TILs and their connections with prognosis in CRC are summarized and insights into the subsets-specific nature of Tils with different MSI status are provided.
Journal ArticleDOI
Inflammatory memory and tissue adaptation in sickness and in health
Shruti Naik,Elaine Fuchs +1 more
TL;DR: A review on inflammatory memory in non-immune cells of different epithelia and neurons, and the potential mechanisms controlling these epigenetic memories and their implications in human health and disease is presented in this article .
References
More filters
Journal ArticleDOI
The orchestrated functions of innate leukocytes and t cell subsets contribute to humoral immunity, virus control, and recovery from secondary poxvirus challenge
TL;DR: Investigation of the contribution of NK cells, granulocytes, and pDC to virus control during a secondary virus challenge in mice that had been primed with an avirulent, mutant strain of ECTV indicates that in the absence of innate cell subsets, a critical role for both CD4 and CD8 T cells becomes apparent and, conversely, in the presence of T cell subset, innate immune cells help contain infection.
Journal ArticleDOI
Phenotypic and Functional Characterization of Circulatory, Splenic, and Hepatic NK Cells in Simian Immunodeficiency Virus-Controlling Macaques.
Diego A. Vargas-Inchaustegui,Sabrina Helmold Hait,Hye Kyung Chung,Jigna Narola,Tanya Hoang,Marjorie Robert-Guroff +5 more
TL;DR: Although SIV infection resulted in NK cell dysfunction, double-negative NK cells and those expressing CXCR3, NKG2D, and IL-18Rα were associated with viremia control, as was Ab-dependent cytotoxic function.
Journal ArticleDOI
Proceedings from the Second Haploidentical Stem Cell Transplantation Symposium—Haplo2014, San Francisco, California, December 4, 2014
Monzr M. Al Malki,Mary M. Horowitz,Rupert Handgretinger,Wing Leung,Denis-Claude Roy,Xiao-Jun Huang,Ephraim J. Fuchs,Franco Locatelli,Didier Blaise,Shin Mineishi,Massimo F. Martelli,Jeffrey S. Miller,Carl H. June,Hui sheng Ai,Leo Luznik,Domenico Mavilio,Enrico Lugli,Marcel R.M. van den Brink,Richard E. Champlin,Stefan O. Ciurea +19 more
TL;DR: This symposium has focused on some of the most promising methods to control alloreactivity in this form of transplantation and application of cellular therapy to prevent disease relapse after transplantation, as well as understanding immunologic reconstitution and foreseeable approaches to improve immune recovery after transplation.
Journal ArticleDOI
Intracellular IFNγ production in CD3 negative cells exposed to allo-antigens is an indicator of prior sensitization
Mieko Toyoda,Andy Pao,Ashley Vo,Marina Lukovsky,Raju Radha,Tetsu Sado,Shili Ge,Nancy L. Reinsmoen,Ning Ning Chai,Lara Baden,Anna Petrosyan,Edwina Skinner,James Mirocha,Stanley C. Jordan +13 more
TL;DR: An intracellular cytokine flow cytometry (CFC) assay that detects intrACEllular gamma-interferon (IFNgamma) production in non-T cell populations (CD3-) that appears to assess sensitization from previous allo-Ag exposure is reported on, which may represent a novel approach to measurement ofallo-sensitization with clinical utility in predicting those at risk for AMR.
Journal ArticleDOI
Adaptation and memory in innate immunity.
TL;DR: In this issue, the current issue of Seminars in Immunology compiles a series of review articles that present the state-of-the-art literature and oncepts on several important aspects concerning innate immune emory/trained immunity.