Open AccessJournal Article
Adaptive Immune Features of Natural Killer Cells
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In this paper, the authors used a mouse model of cytomegalovirus infection to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100fold in the spleen and 1,000-fold in liver after infection.Abstract:
In an adaptive immune response, naive T cells proliferate during infection and generate long-lived memory cells that undergo secondary expansion after a repeat encounter with the same pathogen. Although natural killer (NK) cells have traditionally been classified as cells of the innate immune system, they share many similarities with cytotoxic T lymphocytes. We use a mouse model of cytomegalovirus infection to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100-fold in the spleen and 1,000-fold in the liver after infection. After a contraction phase, Ly49H-positive NK cells reside in lymphoid and non-lymphoid organs for several months. These self-renewing 'memory' NK cells rapidly degranulate and produce cytokines on reactivation. Adoptive transfer of these NK cells into naive animals followed by viral challenge results in a robust secondary expansion and protective immunity. These findings reveal properties of NK cells that were previously attributed only to cells of the adaptive immune system.read more
Citations
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References
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Journal ArticleDOI
Phenotypic and Functional Analysis of Human NK Cell Subpopulations According to the Expression of FcεRIγ and NKG2C
Kyung Hwan Kim,Hee Tae Yu,Hee Tae Yu,Ilwoong Hwang,Sungha Park,Su-Hyung Park,Sungjin Kim,Eui-Cheol Shin +7 more
TL;DR: The heterogeneity of memory-like NK cells stratified by FcεRIγ and NKG2C is demonstrated and it is suggested both markers be utilized to better define these cells.
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The interplay between innate lymphoid cells and T cells.
TL;DR: In this paper, the diversity of functional interactions between T cells and ILCs during homeostasis and immune responses is discussed, and the location and the nature of the tissue microenvironment in which these interactions are taking place may uncover the remaining mysteries of their close encounters.
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Adaptive Characteristics of Innate Immune Responses in Macrophages
Rob J.W. Arts,Mihai G. Netea +1 more
TL;DR: This review gives a general overview of the at-the-moment available data on cells of the innate immune system, and especially monocytes and macrophages, capable of building a nonspecific memory, resulting in either better or worse responses to secondary stimulations/infections, as a result of epigenetic changes.
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CD56 dim CD57 - NKG2C + NK cells retaining proliferative potential are possible precursors of CD57 + NKG2C + memory-like NK cells.
Polina A. Kobyzeva,Maria A. Streltsova,Sofya A. Erokhina,Leonid M. Kanevskiy,William G. Telford,Alexander M. Sapozhnikov,Elena I. Kovalenko +6 more
TL;DR: It is shown that NK cells have certain phenotypic plasticity and may both lose NKG2C expression and acquire it de novo during proliferation, induced by IL‐2 and K562‐mbIL21 feeder cells.
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Immunomodulation by the estrogen metabolite 2-methoxyestradiol
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