Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration.
Thomas H. Ambrosi,Antonio Scialdone,Antonia Graja,Sabrina Gohlke,Anne Marie Jank,Carla Bocian,Lena Woelk,Hua Fan,Darren W. Logan,Annette Schürmann,Luis R. Saraiva,Tim J. Schulz +11 more
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TLDR
A mesenchymal sub-population with stem cell-like characteristics that gives rise to both lineages and, at the same time, acts as a principal component of the hematopoietic niche by promoting competitive repopulation following lethal irradiation is described.About:
This article is published in Cell Stem Cell.The article was published on 2017-06-01 and is currently open access. It has received 511 citations till now. The article focuses on the topics: Bone regeneration & Bone marrow.read more
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Adipogenesis and metabolic health
TL;DR: Interestingly, adipose tissue expansion through the generation of new adipocytes (adipogenesis), rather than through increasing adipocyte size, can prevent this metabolic decline, and a better understanding of adipogenesis can inform new strategies to increase metabolic health in humans.
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Haematopoietic stem cell activity and interactions with the niche.
Sandra Pinho,Paul S. Frenette +1 more
TL;DR: Advances in understanding of HSC regulation by niches during homeostasis, ageing and cancer are reviewed and their implications for the development of therapies to rejuvenate aged HSCs or niches or to disrupt self-reinforcing malignant niches are discussed.
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From haematopoietic stem cells to complex differentiation landscapes
Elisa Laurenti,Berthold Göttgens +1 more
TL;DR: These evolving views of haematopoiesis have broad implications for the understanding of the functions of adult stem cells, as well as the development of new therapies for malignant and non-malignant haem atopoietic diseases.
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Identification of a mesenchymal progenitor cell hierarchy in adipose tissue
David Merrick,Alexander P. Sakers,Zhazira Irgebay,Chihiro Okada,Catherine Calvert,Michael Morley,Ivona Percec,Patrick Seale +7 more
TL;DR: Single-cell RNA sequencing was used to identify distinct types of progenitor cells in murine and human adipose tissues and to predict lineage relationships in an unbiased manner, identifying a mesenchymal cell hierarchy involved in adipocyte formation.
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Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis
Mikolaj Ogrodnik,Mikolaj Ogrodnik,Yi Zhu,Larissa G.P. Langhi,Tamar Tchkonia,Patrick Krüger,Edward Fielder,Stella Victorelli,Rifqha A. Ruswhandi,Nino Giorgadze,Tamar Pirtskhalava,Oleg Podgorni,Grigori Enikolopov,Kurt O. Johnson,Ming Xu,Christine Inman,Allyson K. Palmer,Marissa J. Schafer,Moritz Weigl,Yuji Ikeno,Terry C. Burns,João F. Passos,João F. Passos,Thomas von Zglinicki,Thomas von Zglinicki,James L. Kirkland,Diana Jurk,Diana Jurk +27 more
TL;DR: It is found that obesity results in the accumulation of senescent glial cells in proximity to the lateral ventricle, a region in which adult neurogenesis occurs, and that senolytics are a potential new therapeutic avenue for treating neuropsychiatric disorders.
References
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Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
Simón Méndez-Ferrer,Tatyana V. Michurina,Francesca Ferraro,Amin R. Mazloom,Ben D. MacArthur,Ben D. MacArthur,Sergio A. Lira,David T. Scadden,Avi Ma'ayan,Grigori Enikolopov,Paul S. Frenette,Paul S. Frenette +11 more
TL;DR: It is demonstrated that mesenchymal stem cells (MSCs), identified using nestin expression, constitute an essential HSC niche component and are indicative of a unique niche in the bone marrow made of heterotypic stem-cell pairs.
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The bone marrow niche for haematopoietic stem cells
TL;DR: The haematopoietic stem cell niche remains incompletely defined and beset by competing models, and outstanding questions concern the cellular complexity of the niche, the role of the endosteum and functional heterogeneity among perivascular microenvironments.
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Endothelial and perivascular cells maintain haematopoietic stem cells
TL;DR: HSCs reside in a perivascular niche in which multiple cell types express factors that promote HSC maintenance, and were depleted from bone marrow when Scf was deleted from endothelial cells or leptin receptor (Lepr)-expressing periv vascular stromal cells.
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Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone
TL;DR: In this paper, the authors identify a new capillary subtype in the murine skeletal system with distinct morphological, molecular and functional properties, which mediate growth of the bone vasculature, generate distinct metabolic and molecular microenvironments, maintain perivascular osteoprogenitors and couple angiogenesis to osteogenesis.
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Fracture healing: mechanisms and interventions
TL;DR: The developmental progression of fracture healing at the tissue, cellular and molecular levels is reviewed and strategies for fracture treatment that have been tested in animal models and in clinical trials or case series are presented.