Journal ArticleDOI
Adipose tissue: new therapeutic targets from molecular and genetic studies – IASO Stock Conference 2003 report
Stephen R. Farmer,J. Auwerx +1 more
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This review highlights the presentations and discussions held during the 2003 Stock Conference in Lisbon focussed on the identification of new therapeutic targets for the treatment of obesity and identified through molecular and genetic studies.Abstract:
This review highlights the presentations and discussions held during the 2003 Stock Conference in Lisbon focussed on the identification of new therapeutic targets for the treatment of obesity and identified through molecular and genetic studies. Transcription factors and their cofactors, signalling pathways and new insights provided by cellular and genetic studies were discussed as potential new avenues to modulate adipocyte formation and functionread more
Citations
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PPARγ activation in adipocytes is sufficient for systemic insulin sensitization
Shigeki Sugii,Peter Olson,Peter Olson,Dorothy D. Sears,Maziyar Saberi,Annette R. Atkins,Grant D. Barish,Suk Hyun Hong,Glenda L. Castro,Yun Qiang Yin,Michael C. Nelson,Michael C. Nelson,Gene Hsiao,David R. Greaves,Michael Downes,Ruth T. Yu,Jerrold M. Olefsky,Ronald M. Evans,Ronald M. Evans,Ronald M. Evans +19 more
TL;DR: It is found that selective activation of PPARγ in adipocytes, but not in macrophages, is sufficient for whole-body insulin sensitization equivalent to systemic TZD treatment, and a specific application for fat selective PParγ modulators in diabetic therapy is suggested.
Journal ArticleDOI
Inhibitory Effect of (-)-Epigallocatechin-3-Gallate on Lipid Accumulation of 3T3-L1 Cells
TL;DR: The molecular mechanisms underlying the attenuating effect of (−)‐epigallocatechin‐3‐gallate (EGCG) on proliferation and lipid accumulation of 3T3‐L1 cells are investigated with a focus on the duration of EGCG treatment.
Journal ArticleDOI
Proposed mechanisms of (-)-epigallocatechin-3-gallate for anti-obesity
TL;DR: It was shown that dietary supplementation with EGCG could potentially contribute to nutritional strategies for the prevention and treatment of type 2 diabetes mellitus and the catechin components of green tea have been shown to possess anti-carcinogenic properties possibly related to their anti-oxidant activity.
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Antiobesity effects of quercetin-rich onion peel extract on the differentiation of 3T3-L1 preadipocytes and the adipogenesis in high fat-fed rats.
TL;DR: The results suggest that quercentin-enriched OPE may have antiobesity effects by suppressing preadipocyte differentiation and inhibiting adipogenesis.
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The KLF2 transcription factor does not affect the formation of preadipocytes but inhibits their differentiation into adipocytes.
TL;DR: It is demonstrated that KLF2 does not affect the commitment of multipotent stem cells into the preadipocytic lineage but rather maintains theirPreadipocyte state and thereby negatively regulates their transition into adipocytes.
References
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Journal ArticleDOI
cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1).
Kazuhisa Maeda,Kousaku Okubo,Iichiro Shimomura,Tohru Funahashi,Yuji Matsuzawa,Kenichi Matsubara +5 more
TL;DR: The apM1 gene encodes a 244 amino acid open reading frame containing a putative signal sequence and G-X-Y repeats (66 amino acids) followed by a cluster of aromatic residues near the C terminus having high local similarity with collagens X and VIII and complement factor C1q.
Journal ArticleDOI
FoxOs at the crossroads of cellular metabolism, differentiation, and transformation.
Domenico Accili,Karen C. Arden +1 more
TL;DR: Forkhead transcription factors of the FoxO subfamily are emerging as a shared component among pathways regulating diverse cellular functions, such as differentiation, metabolism, proliferation, and survival, according to their two-tiered mechanism of phosphorylation and acetylation.
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Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity
Yong-Xu Wang,Chih-Hao Lee,Chih-Hao Lee,Sambath Tiep,Ruth T. Yu,Jungyeob Ham,Heonjoong Kang,Ronald M. Evans,Ronald M. Evans +8 more
TL;DR: It is shown here that targeted activation of PPARδ in adipose tissue specifically induces expression of genes required for fatty acid oxidation and energy dissipation, which in turn leads to improved lipid profiles and reduced adiposity.
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Impaired energy homeostasis in C/EBP alpha knockout mice.
Nai-dy Wang,Milton J. Finegold,Allan Bradley,Ching N. Ou,Sandy V. Abdelsayed,Margaret Wilde,L. Ranee Taylor,Deborah R. Wilson,Gretchen J. Darlington +8 more
TL;DR: It is demonstrated that C/EBP alpha is critical for the establishment and maintenance of energy homeostasis in neonates and the expression of the gene for uncoupling protein, the defining marker of brown adipose tissue, was reduced.
Journal ArticleDOI
Induction of Adiponectin, a Fat-Derived Antidiabetic and Antiatherogenic Factor, by Nuclear Receptors
Masanori Iwaki,Morihiro Matsuda,Norikazu Maeda,Tohru Funahashi,Yuji Matsuzawa,Makoto Makishima,Iichiro Shimomura +6 more
TL;DR: The results indicate that PPAR-gamma and LRH-1 play significant roles in the transcriptional activation of adiponectin gene via the PPRE and theLRH-RE in its promoter.