Age as a Confounding Factor for the Accurate Non-Invasive Diagnosis of Advanced NAFLD Fibrosis
Stuart McPherson,Stuart McPherson,Timothy Hardy,Timothy Hardy,Jean-François Dufour,Salvatore Petta,Manuel Romero-Gómez,M. Allison,Claudia P. Oliveira,Sven Francque,Luc Van Gaal,Jörn M. Schattenberg,Dina Tiniakos,Dina Tiniakos,Alastair D. Burt,Elisabetta Bugianesi,Vlad Ratziu,Christopher P. Day,Christopher P. Day,Quentin M. Anstee,Quentin M. Anstee +20 more
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TLDR
The NFS and FIB-4 scores have similar accuracy for advanced fibrosis in patients aged >35 years, however, the specificity forAdvanced fibrosis is unacceptably low in patients ages aged ≥65 years, resulting in a high false positive rate.About:
This article is published in The American Journal of Gastroenterology.The article was published on 2017-05-01 and is currently open access. It has received 463 citations till now. The article focuses on the topics: Confounding.read more
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MAFLD: A Consensus-Driven Proposed Nomenclature for Metabolic Associated Fatty Liver Disease.
TL;DR: Experts reached consensus that NAFLD does not reflect current knowledge and metabolic (dysfunction) associated fatty liver disease "MAFLD" was suggested as a more appropriate overarching term and opens the door for efforts from the research community to update the nomenclature and sub-phenotype the disease in order to accelerate the translational path to new treatments.
Journal ArticleDOI
Modeling NAFLD Disease Burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030
Chris Estes,Quentin M. Anstee,María Teresa Arias-Loste,Heike Bantel,Stefano Bellentani,Joan Caballería,Massimo Colombo,Antonio Craxì,Javier Crespo,Christopher P. Day,Yuichiro Eguchi,Andreas Geier,Loreta A. Kondili,Daniela C. Kroy,Jeffrey V. Lazarus,Rohit Loomba,Michael P. Manns,Giulio Marchesini,Atsushi Nakajima,Francesco Negro,Salvatore Petta,V. Ratziu,Manuel Romero-Gómez,Arun J. Sanyal,Jörn M. Schattenberg,Frank Tacke,Junko Tanaka,Christian Trautwein,Lai Wei,Stefan Zeuzem,Homie Razavi +30 more
TL;DR: NAFLD and NASH represent a large and growing public health problem and efforts to understand this epidemic and to mitigate the disease burden are needed, if obesity and DM continue to increase at current and historical rates.
Journal ArticleDOI
Noninvasive Assessment of Liver Disease in Patients With Nonalcoholic Fatty Liver Disease.
TL;DR: The current state of the noninvasive assessment of liver disease in NAFLD is summarized, and an expert synthesis of how these nonin invasive tools could be utilized in clinical practice is provided.
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Comparison of laboratory tests, ultrasound, or magnetic resonance elastography to detect fibrosis in patients with nonalcoholic fatty liver disease: A meta-analysis.
TL;DR: MRE and SWE may have the highest diagnostic accuracy for staging fibrosis in NAFLD patients, and among the four noninvasive simple indexes, NFS and FIB‐4 probably offer the best diagnostic performance for detecting AF.
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Nonalcoholic Fatty Liver Disease 2020: The State of the Disease
Thomas G. Cotter,Mary E. Rinella +1 more
TL;DR: An update is provided on the epidemiology, clinical and prognostic features, and diagnostic approach to patients with NAFLD, with a view to targeting resources to those who need it most.
References
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FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest.
Anaïs Vallet-Pichard,Anaïs Vallet-Pichard,Vincent Mallet,Vincent Mallet,Bertrand Nalpas,Bertrand Nalpas,Virginie Verkarre,Antoine Nalpas,Valérie Dhalluin-Venier,Hélène Fontaine,Hélène Fontaine,Stanislas Pol,Stanislas Pol +12 more
TL;DR: For values outside 1.45‐3.25, the FIB‐4 index is a simple, accurate, and inexpensive method for assessing liver fibrosis and proved to be concordant with FibroTest results.
Journal ArticleDOI
Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis.
TL;DR: The evidence that suggests NAFLD is a multisystem disease and the factors that might determine interindividual variation in the development and progression of its major hepatic and extrahepatic manifestations are reviewed.
Journal ArticleDOI
Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease
Vincent Wai-Sun Wong,Julien Vergniol,Grace Lai-Hung Wong,Juliette Foucher,Henry Lik-Yuen Chan,Brigitte Le Bail,Paul Cheung-Lung Choi,Mathurin Kowo,Anthony W.H. Chan,Wassil Merrouche,Joseph J.Y. Sung,Victor de Ledinghen +11 more
TL;DR: Transient elastography is accurate in most NAFLD patients and is useful as a screening test to exclude advanced fibrosis, and liver biopsy may be considered in patients with liver stiffness of at least 7.9 kPa.
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Pitfalls of liver stiffness measurement: a 5-year prospective study of 13,369 examinations.
Laurent Castera,Juliette Foucher,Pierre-Henri Bernard,Françoise Carvalho,Daniele Allaix,Wassil Merrouche,Patrice Couzigou,Victor de Ledinghen +7 more
TL;DR: In the authors' experience, liver stiffness measurements are uninterpretable in nearly one in five cases, the principal reasons are obesity, particularly increased waist circumference, and limited operator experience.
Journal ArticleDOI
Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease.
TL;DR: The FIB4 index is superior to 7 other non invasive markers of fibrosis in patients with NAFLD; however its performance characteristics highlight the need for even better noninvasive markers.