Age as a Confounding Factor for the Accurate Non-Invasive Diagnosis of Advanced NAFLD Fibrosis
Stuart McPherson,Stuart McPherson,Timothy Hardy,Timothy Hardy,Jean-François Dufour,Salvatore Petta,Manuel Romero-Gómez,M. Allison,Claudia P. Oliveira,Sven Francque,Luc Van Gaal,Jörn M. Schattenberg,Dina Tiniakos,Dina Tiniakos,Alastair D. Burt,Elisabetta Bugianesi,Vlad Ratziu,Christopher P. Day,Christopher P. Day,Quentin M. Anstee,Quentin M. Anstee +20 more
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TLDR
The NFS and FIB-4 scores have similar accuracy for advanced fibrosis in patients aged >35 years, however, the specificity forAdvanced fibrosis is unacceptably low in patients ages aged ≥65 years, resulting in a high false positive rate.About:
This article is published in The American Journal of Gastroenterology.The article was published on 2017-05-01 and is currently open access. It has received 463 citations till now. The article focuses on the topics: Confounding.read more
Citations
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Predictors of advanced fibrosis in non-cirrhotic non-alcoholic fatty liver disease in Germany
Christian Labenz,Yvonne Huber,Eva Kalliga,Michael Nagel,Christian Ruckes,Beate K. Straub,Peter R. Galle,Marcus-Alexander Wörns,Quentin M. Anstee,Quentin M. Anstee,Detlef Schuppan,Jörn M. Schattenberg +11 more
TL;DR: Advanced fibrosis has been established as the most important predictor of overall mortality in patients with non‐alcoholic fatty liver disease (NAFLD), but in contrast to cirrhosis, advanced, non‐cirrhotic NAFLD is difficult to identify and data from Germany are lacking.
Journal ArticleDOI
Significant burden of nonalcoholic fatty liver disease with advanced fibrosis in the US: a cross-sectional analysis of 2011-2014 National Health and Nutrition Examination Survey.
TL;DR: The epidemiology of NAFLD, with specific focus on individuals with hepatic fibrosis, is important to guide healthcare resource planning.
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Alcoholic Liver Disease Epidemiology in the United States: A Retrospective Analysis of 3 US Databases.
TL;DR: Significant observations of increasing ALD severity emphasize the urgent need for greater awareness about the consequences of unhealthy alcohol use and interventions aimed specifically at addressing alcohol use disorders.
Journal ArticleDOI
Liver stiffness measurement predicts long‐term survival and complications in non‐alcoholic fatty liver disease
Sarah Shili-Masmoudi,Grace Lai-Hung Wong,Jean-Baptiste Hiriart,Ken Liu,Ken Liu,Faiza Chermak,Sally She-Ting Shu,Juliette Foucher,Yee-Kit Tse,Pierre-Henri Bernard,Terry Cheuk-Fung Yip,Wassil Merrouche,Henry Lik-Yuen Chan,Vincent Wai-Sun Wong,Victor de Lédinghen +14 more
TL;DR: The ability of liver stiffness measurement (LSM) to predict overall survival and liver, cardiovascular and oncologic complications in non‐alcoholic fatty liver disease is evaluated.
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A stepwise algorithm using an at-a-glance first-line test for the non-invasive diagnosis of advanced liver fibrosis and cirrhosis
Jérôme Boursier,Victor de Ledinghen,Vincent Leroy,Rodolphe Anty,Sven Francque,Dominique Salmon,Adrien Lannes,Sandrine Bertrais,Frédéric Oberti,Isabelle Fouchard-Hubert,Paul Calès +10 more
TL;DR: The eLIFT-FMVCTE algorithm extends the detection of advanced liver fibrosis to all CLD patients and reduces unnecessary referrals of patients without significant CLD to hepatologists.
References
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David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
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Jeffrey D. Browning,Lidia S. Szczepaniak,Robert L. Dobbins,Pamela Nuremberg,Jay D. Horton,Jonathan Cohen,Scott M. Grundy,Helen H. Hobbs +7 more
TL;DR: The prevalence of hepatic steatosis was greater in men than women among whites, but not in blacks or Hispanics, and significant ethnic and sex differences in the prevalence may have a profound impact on susceptibility to Steatosis‐related liver disease.
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The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
Naga Chalasani,Zobair M. Younossi,Joel E. Lavine,Anna Mae Diehl,Elizabeth M. Brunt,Kenneth Cusi,Michael Charlton,Arun J. Sanyal +7 more
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Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection
Richard K. Sterling,Eduardo Lissen,Eduardo Lissen,Nathan Clumeck,Ricard Solà,Mendes Cassia Correa,Julio S. G. Montaner,Mark S. Sulkowski,Francesca J. Torriani,Doug T. Dieterich,David L. Thomas,Diethelm Messinger,Mark T. Nelson +12 more
TL;DR: In conclusion, noninvasive tests can accurately predict hepatic fibrosis and may reduce the need for liver biopsy in the majority of HIV/HCV‐coinfected patients.