Age as a Confounding Factor for the Accurate Non-Invasive Diagnosis of Advanced NAFLD Fibrosis
Stuart McPherson,Stuart McPherson,Timothy Hardy,Timothy Hardy,Jean-François Dufour,Salvatore Petta,Manuel Romero-Gómez,M. Allison,Claudia P. Oliveira,Sven Francque,Luc Van Gaal,Jörn M. Schattenberg,Dina Tiniakos,Dina Tiniakos,Alastair D. Burt,Elisabetta Bugianesi,Vlad Ratziu,Christopher P. Day,Christopher P. Day,Quentin M. Anstee,Quentin M. Anstee +20 more
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TLDR
The NFS and FIB-4 scores have similar accuracy for advanced fibrosis in patients aged >35 years, however, the specificity forAdvanced fibrosis is unacceptably low in patients ages aged ≥65 years, resulting in a high false positive rate.About:
This article is published in The American Journal of Gastroenterology.The article was published on 2017-05-01 and is currently open access. It has received 463 citations till now. The article focuses on the topics: Confounding.read more
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Fibrosis-4 (FIB-4) score at the primary care level: an analysis of over 160 000 blood samples
TL;DR: The recent article by Newsome et al which provides guidelines on the management of abnormal liver blood tests based on the clinical recognition pattern of elevated liver enzymes and recommendations on non-invasive laboratory based liver fibrosis scores such as Fibrosis-4 (FIB-4) to exclude advanced fibrosis was read with interest.
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Accuracy of Fibrosis-4 Index in Identification of Patients with Cirrhosis Who Could Potentially Avoid Variceal Screening Endoscopy.
Koji Ishida,Tadashi Namisaki,Koji Murata,Yuki Fujimoto,Souichi Takeda,Masahide Enomoto,Hiroyuki Ogawa,Hirotetsu Takagi,Yuki Tsuji,Daisuke Kaya,Yukihisa Fujinaga,Masanori Furukawa,Yasuhiko Sawada,Koh Kitagawa,Shinya Sato,Norihisa Nishimura,Hiroaki Takaya,Kosuke Kaji,Naotaka Shimozato,Hideto Kawaratani,Kei Moriya,Takemi Akahane,Akira Mitoro,Hitoshi Yoshiji +23 more
TL;DR: In this article, the authors identify serum fibrosis indices that might aid in ruling out the presence of high-risk varices in cirrhotic patients, including platelet count, hyaluronic acid, 7S fragment of type 4 collagen, procollagen type III N-terminal peptide, tissue inhibitor of metalloproteinases 1, Mac-2 binding protein glycosylation isomer, fibrosis index based on four factors, aspartate transaminase/platelet ratio index and enhanced liver fibrosis score.
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Feasibility and efficiency of European guidelines for NAFLD assessment in patients with type 2 diabetes: A prospective study.
Giulia Besutti,Giulia Besutti,Lisa Bonilauri,Elisa Manicardi,Francesco Venturelli,Efrem Bonelli,Filippo Monelli,Valeria Manicardi,Luca Valenti,Guido Ligabue,Susanna Schianchi,Marco Massari,Nicoletta Riva,Elisabetta Froio,Elena Tagliavini,Pierpaolo Pattacini,Paolo Giorgi Rossi +16 more
TL;DR: In this article, the feasibility and efficiency of a guidelines-compliant NAFLD assessment algorithm in patients with newly diagnosed type 2 diabetes (T2D) was evaluated in patients who were referred to a hepatologist due to abnormal liver enzymes.
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The future of diagnosing NASH - could a simple blood test be the key?
Sven Francque,Luisa Vonghia +1 more
TL;DR: Non-invasive tools, so called biomarkers, which provide data equivalent to those contained in a liver biopsy specimen, are urgently required for adequate management of NASH, and blood tests are an attractive alternative.
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Non-invasive imaging biomarkers to assess nonalcoholic fatty liver disease: A review.
TL;DR: In this article, a review summarizes the current state of non-invasive diagnosis of nonalcoholic fatty liver disease (NAFLD) using various imaging modalities (imaging biomarkers) including magnetic resonance (MR), computed tomography (CT), and ultrasound-based imaging methods.
References
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Diagnosis and Classification of Diabetes Mellitus
TL;DR: The chronic hyperglycemia of diabetes is associated with long-term damage, dys-function, and failure of differentorgans, especially the eyes, kidneys, nerves, heart, and blood vessels.
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Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
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Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity
Jeffrey D. Browning,Lidia S. Szczepaniak,Robert L. Dobbins,Pamela Nuremberg,Jay D. Horton,Jonathan Cohen,Scott M. Grundy,Helen H. Hobbs +7 more
TL;DR: The prevalence of hepatic steatosis was greater in men than women among whites, but not in blacks or Hispanics, and significant ethnic and sex differences in the prevalence may have a profound impact on susceptibility to Steatosis‐related liver disease.
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The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
Naga Chalasani,Zobair M. Younossi,Joel E. Lavine,Anna Mae Diehl,Elizabeth M. Brunt,Kenneth Cusi,Michael Charlton,Arun J. Sanyal +7 more
TL;DR: This is a practice guideline for clinicians rather than a review article and interested readers can refer to several comprehensive reviews published recently.
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Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection
Richard K. Sterling,Eduardo Lissen,Eduardo Lissen,Nathan Clumeck,Ricard Solà,Mendes Cassia Correa,Julio S. G. Montaner,Mark S. Sulkowski,Francesca J. Torriani,Doug T. Dieterich,David L. Thomas,Diethelm Messinger,Mark T. Nelson +12 more
TL;DR: In conclusion, noninvasive tests can accurately predict hepatic fibrosis and may reduce the need for liver biopsy in the majority of HIV/HCV‐coinfected patients.